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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ia2TQ4Dihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ia2TQ4Dihydrofolate reductase1.5.1.31.000
1m7aMQUDihydrofolate reductase1.5.1.30.793
1m79MQ1Dihydrofolate reductase1.5.1.30.664
1m78CLZDihydrofolate reductase1.5.1.30.654
1ia1TQ3Dihydrofolate reductase1.5.1.30.644
3qlwN22Dihydrofolate reductase1.5.1.30.624
4h9753SDihydrofolate reductase1.5.1.30.606
1ia4TQ6Dihydrofolate reductase1.5.1.30.605
4h9506UDihydrofolate reductase1.5.1.30.595
1aoeGW3Dihydrofolate reductase1.5.1.30.591
1klkPMDDihydrofolate reductase1.5.1.30.590
3qlrQLRDihydrofolate reductase1.5.1.30.564
3qls55VDihydrofolate reductase1.5.1.30.563
1ia3TQ5Dihydrofolate reductase1.5.1.30.555
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.531
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.529
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.528
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.527
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.521
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.516
1dg5TOPDihydrofolate reductase1.5.1.30.512
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.512
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.512
3sh25DRDihydrofolate reductase1.5.1.30.507
3cseN22Uncharacterized protein/0.506
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.506
3eek53SUncharacterized protein/0.503
3eej53RUncharacterized protein/0.500
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.497
3eem53VUncharacterized protein/0.496
3nr4PYVAbscisic acid receptor PYL2/0.496
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.496
3tmz06XCytochrome P450 2B41.14.14.10.495
3k47D09Dihydrofolate reductase1.5.1.30.494
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.493
3sa16DRDihydrofolate reductase/0.493
2w3vTOPDihydrofolate reductase/0.488
3ia4MTXDihydrofolate reductase/0.488
1ie9VDXVitamin D3 receptor/0.487
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.487
3sa27DRDihydrofolate reductase/0.486
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.485
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.483
4xe606UDihydrofolate reductase1.5.1.30.481
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.479
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.479
3qlxQLRUncharacterized protein/0.479
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.478
4p66MTXDihydrofolate reductase/0.478
4zasTYDCalS13/0.476
3tq9MTXDihydrofolate reductase/0.475
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.475
4p68MTXDihydrofolate reductase/0.474
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.473
7dfrFOLDihydrofolate reductase1.5.1.30.473
4cd2FOLDihydrofolate reductase1.5.1.30.472
4g8zTOPDihydrofolate reductase1.5.1.30.472
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.471
3sai9DRDihydrofolate reductase/0.471
1ek2CDUBifunctional epoxide hydrolase 2/0.470
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
3w0c6DSVitamin D3 receptor/0.470
4g1z0VPVitamin D3 receptor A/0.470
2hb7O1CVitamin D3 receptor/0.469
2zlcVDXVitamin D3 receptor/0.469
3sgy06WDihydrofolate reductase1.5.1.30.469
1s19MC9Vitamin D3 receptor/0.468
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
1z6tADPApoptotic protease-activating factor 1/0.466
2jn3JN3Fatty acid-binding protein, liver/0.466
2w3aTOPDihydrofolate reductase1.5.1.30.466
4kbn25UDihydrofolate reductase1.5.1.30.466
4x5gFOLDihydrofolate reductase1.5.1.30.466
2ze2T27Gag-Pol polyprotein2.7.7.490.465
3mdvCL6Cholesterol 24-hydroxylase/0.465
4k9v6AWCytochrome P450 3A4/0.465
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.464
1vj3TABDihydrofolate reductase1.5.1.30.463
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
4x5jFOLDihydrofolate reductase1.5.1.30.462
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2hamC33Vitamin D3 receptor/0.461
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.461
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.461
3oafOAGDihydrofolate reductase1.5.1.30.460
3tq8TOPDihydrofolate reductase/0.460
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4g95OAGDihydrofolate reductase1.5.1.30.460
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4kak06UDihydrofolate reductase1.5.1.30.460
2zl9VDAVitamin D3 receptor/0.459
3ebf332Nitric oxide synthase, inducible1.14.13.390.459
3vrvYSDVitamin D3 receptor/0.459
4nx6FOLDihydrofolate reductase1.5.1.30.459
1hpzAAPGag-Pol polyprotein2.7.7.490.458
2hasC3OVitamin D3 receptor/0.458
2vn0TDZCytochrome P450 2C8/0.458
3qm4PN0Cytochrome P450 2D6/0.458
4gxs0YSGlutamate receptor 2/0.458
3freTOPDihydrofolate reductase1.5.1.30.457
3w0aDS5Vitamin D3 receptor/0.457
4ia7BIVVitamin D3 receptor A/0.457
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.457
4kjjFOLDihydrofolate reductase1.5.1.30.457
1hfpMOTDihydrofolate reductase1.5.1.30.456
1og5SWFCytochrome P450 2C9/0.456
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.456
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4ia1BIVVitamin D3 receptor A/0.456
3a783EVVitamin D3 receptor/0.455
3tdaPN0Cytochrome P450 2D6/0.455
3tqbFOLDihydrofolate reductase/0.455
3ua506XCytochrome P450 2B61.14.130.455
2x7hPFNProstaglandin reductase 310.454
3h3t16HCollagen type IV alpha-3-binding protein/0.454
3lnbCOAN-acetyltransferase family protein/0.454
3nj0PYVAbscisic acid receptor PYL2/0.454
4h9814QUncharacterized protein/0.454
2hcdBIVVitamin D3 receptor A/0.453
4iteTEYVitamin D3 receptor/0.453
4o761M3Bromodomain-containing protein 4/0.453
1crbRTLRetinol-binding protein 1/0.452
1ddsMTXDihydrofolate reductase1.5.1.30.452
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2hb8MVDVitamin D3 receptor/0.452
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.452
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.452
4kd79DRDihydrofolate reductase1.5.1.30.452
3vt5YI2Vitamin D3 receptor/0.451
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.451
2iyaZIOOleandomycin glycosyltransferase/0.450
3m7rVDXVitamin D3 receptor/0.450
3ql3FOLDihydrofolate reductase1.5.1.30.450
4ej1FOLDihydrofolate reductase1.5.1.30.450
4ipw1G7Mycocyclosin synthase1.14.21.90.450
1jioDEB6-deoxyerythronolide B hydroxylase/0.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3gc9B45Mitogen-activated protein kinase 112.7.11.240.449
3lfcZ86Mitogen-activated protein kinase 14/0.449
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1s3yTQTDihydrofolate reductase1.5.1.30.448
2drcMTXDihydrofolate reductase1.5.1.30.448
2feuCAMCamphor 5-monooxygenase1.14.15.10.448
2ph5NADHomospermidine synthase/0.448
3vi7CBDHematopoietic prostaglandin D synthase/0.448
4qa2SHHHistone deacetylase 83.5.1.980.448
1bk0ACVIsopenicillin N synthase1.21.3.10.447
2hc4VDXVitamin D3 receptor A/0.447
3cv9VDXVitamin D3 dihydroxylase/0.447
3vt65YIVitamin D3 receptor/0.447
4kfj1R0Dihydrofolate reductase1.5.1.30.447
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
1db1VDXVitamin D3 receptor/0.446
1rk3VDXVitamin D3 receptor/0.446
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.446
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.446
3irxUDRGag-Pol polyprotein2.7.7.490.446
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3vt7VDXVitamin D3 receptor/0.446
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
3jw5TOPDihydrofolate reductase/0.445
3kpzZNEVitamin D3 receptor/0.445
3p99LNPLanosterol 14-alpha-demethylase/0.445
3vtbTKAVitamin D3 receptor/0.445
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.445
4mv1ADPBiotin carboxylase6.3.4.140.445
4r21STRCytochrome P450 family 17 polypeptide 2/0.445
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2bxoOPBSerum albumin/0.444
3gwfFADCyclohexanone monooxygenase/0.444
3vrwYS5Vitamin D3 receptor/0.444
3vt3VDXVitamin D3 receptor/0.444
4ib4ERM5-hydroxytryptamine receptor 2B/0.444
1bozPRDDihydrofolate reductase1.5.1.30.443
1draMTXDihydrofolate reductase1.5.1.30.443
1kkq471Peroxisome proliferator-activated receptor alpha/0.443
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1re7FOLDihydrofolate reductase1.5.1.30.443
1t85CAMCamphor 5-monooxygenase1.14.15.10.443
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2m56CAMCamphor 5-monooxygenase1.14.15.10.443
3h3sH15Collagen type IV alpha-3-binding protein/0.443
3is9AC7Gag-Pol polyprotein2.7.7.490.443
3ns2PYVAbscisic acid receptor PYL2/0.443
4i6gFADCryptochrome-2/0.443
4ia3BIVVitamin D3 receptor A/0.443
4u0oMTALipoyl synthase 2/0.443
1rf9DBRCamphor 5-monooxygenase1.14.15.10.442
1rx7FOLDihydrofolate reductase1.5.1.30.442
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3k4551PDihydrofolate reductase1.5.1.30.442
3l8sBFFMitogen-activated protein kinase 14/0.442
3nxvD2FDihydrofolate reductase1.5.1.30.442
3w0yDS4Vitamin D3 receptor/0.442
4enhFVXCholesterol 24-hydroxylase/0.442
4hnc0UTMandelate racemase/0.442
1c1c612Gag-Pol polyprotein2.7.7.490.441
1dyhDZFDihydrofolate reductase1.5.1.30.441
1rx8FOLDihydrofolate reductase1.5.1.30.441
1s9qOHTEstrogen-related receptor gamma/0.441
1t86CAMCamphor 5-monooxygenase1.14.15.10.441
1vrwNAIEnoyl-ACP reductase/0.441
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2fpcSCGStrictosidine synthase4.3.3.20.441
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.441
3u8hBHPPhospholipase A2, membrane associated/0.441
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
3reyXACAdenosine receptor A2a/0.441
1c1bGCAGag-Pol polyprotein2.7.7.490.440
1uzwCDHIsopenicillin N synthase1.21.3.10.440
2g5oDRQEstrogen receptor/0.440
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.440
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3i8aN22Dihydrofolate reductase1.5.1.30.440
3p3zP3ZPutative cytochrome P450/0.440
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
3qly55VUncharacterized protein/0.440
5cccDDFDihydrofolate reductase1.5.1.30.440