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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5a06 NDP Glucose-fructose oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5a06 NDPGlucose-fructose oxidoreductase / 1.384
5a02 NAPGlucose-fructose oxidoreductase / 1.359
5a04 NDPGlucose-fructose oxidoreductase / 1.339
5a03 NDPGlucose-fructose oxidoreductase / 1.319
5a05 NDPGlucose-fructose oxidoreductase / 1.302
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 1.174
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 1.068
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 1.066
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 1.055
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 1.042
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 1.036
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.970
1zh8 NAPUncharacterized protein / 0.901
2glx NDP1,5-anhydro-D-fructose reductase / 0.831
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.805
1rye NDPGlucose--fructose oxidoreductase 1.1.99.28 0.798
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.794
3q2k NAIProbable oxidoreductase / 0.767
1yqd NAPSinapyl alcohol dehydrogenase / 0.760
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.736
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.730
2h63 NAPBiliverdin reductase A 1.3.1.24 0.729
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.714
4oaq NDPR-specific carbonyl reductase / 0.711
5bsg NAPPyrroline-5-carboxylate reductase / 0.706
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.702
4gmg NAPYersiniabactin biosynthetic protein YbtU / 0.699
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.695
5bsf NADPyrroline-5-carboxylate reductase / 0.693
8dfr NDPDihydrofolate reductase 1.5.1.3 0.691
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.690
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.690
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.683
2rcy NAPPyrroline-5-carboxylate reductase / 0.681
3ec7 NADInositol 2-dehydrogenase / 0.681
3two NDPMannitol dehydrogenase / 0.680
4pxz CLRP2Y purinoceptor 12 / 0.680
2f1k NAPPrephenate dehydrogenase / 0.679
2vf7 ADPUvrABC system protein A / 0.678
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.677
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.676
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.675
2c29 NAPDihydroflavonol 4-reductase / 0.674
3f3s NADLambda-crystallin homolog / 0.671
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.671
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.670
3ikt NADRedox-sensing transcriptional repressor Rex / 0.670
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.668
2voj NADAlanine dehydrogenase 1.4.1.1 0.667
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.666
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
3nx4 NAPPutative oxidoreductase / 0.666
1yqx NAPSinapyl alcohol dehydrogenase / 0.665
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.665
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.664
3tdk UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.664
4xgi NADGlutamate dehydrogenase / 0.663
1zgd NAPChalcone reductase / 0.662
3m2t NADProbable dehydrogenase / 0.662
1pjc NADAlanine dehydrogenase / 0.661
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.661
3tri NAPPyrroline-5-carboxylate reductase / 0.660
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.658
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.658
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
4kqw NAPKetol-acid reductoisomerase (NADP(+)) / 0.658
3jv7 NADSecondary alcohol dehydrogenase / 0.657
4hwk NAPSepiapterin reductase 1.1.1.153 0.657
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.657
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.654
1lj8 NADMannitol dehydrogenase / 0.654
1mv8 GDXGDP-mannose 6-dehydrogenase 1.1.1.132 0.654
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.654
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.654
4b7x NAPProbable oxidoreductase / 0.654
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.654
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.652
2gn4 UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.651
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.650
2yut NAPPutative short-chain oxidoreductase / 0.650
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650