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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zuk NAD Alpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.840
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.801
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.766
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.751
3b4w NADAldehyde dehydrogenase family protein / 0.750
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.749
4i3v NADAldehyde dehydrogenase (NAD+) / 0.745
2jg7 NADAntiquitin / 0.743
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.741
4i3w NADAldehyde dehydrogenase (NAD+) / 0.739
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.738
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.736
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.728
1bi9 NADRetinal dehydrogenase 2 / 0.727
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.726
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.722
4pxl NADAldehyde dehydrogenase3 / 0.721
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.720
4pt0 NADAldehyde dehydrogenase / 0.719
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.717
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.717
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.717
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.716
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.716
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.715
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.714
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.714
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.711
4i9b NADPutative betaine aldehyde dehyrogenase / 0.711
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.710
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.709
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.709
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.707
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.706
4i8p NADAminoaldehyde dehydrogenase 1 / 0.706
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.704
3iwj NADAminoaldehyde dehydrogenase / 0.704
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.702
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.701
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.700
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.699
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.698
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.698
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.695
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.695
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.695
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.694
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.693
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.692
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.688
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.686
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.684
4nmj NAPAldehyde dehydrogenase / 0.683
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.682
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.680
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.678
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.677
4h73 NDPAldehyde dehydrogenase / 0.676
5ez4 NADBetaine-aldehyde dehydrogenase / 0.675
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.674
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.671
4i8q NADPutative betaine aldehyde dehyrogenase / 0.671
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.668
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.666
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.663
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.662
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.660
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.657
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.657
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.653
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.652
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.650