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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4y0x ADP Serine/threonine-protein kinase PknG 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.950
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.907
2pui ADPMethylthioribose kinase 2.7.1.100 0.776
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.742
2pul ACPMethylthioribose kinase 2.7.1.100 0.738
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.736
2olc ADPMethylthioribose kinase 2.7.1.100 0.728
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.721
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.721
2py3 ACPFibroblast growth factor receptor 2 / 0.719
2pun ACPMethylthioribose kinase 2.7.1.100 0.717
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.713
3q5i ANPProtein kinase, putative / 0.712
3c4z ADPRhodopsin kinase / 0.711
4xlv ACPInsulin receptor 2.7.10.1 0.710
3c4w ATPRhodopsin kinase / 0.708
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.707
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.704
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.704
3qc9 ADPRhodopsin kinase / 0.702
4gyi ADPUncharacterized protein / 0.702
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.701
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.700
2pz5 ACPFibroblast growth factor receptor 2 / 0.700
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.700
4o1p ANPRibonuclease L / 0.700
1pjk ANPCasein kinase II subunit alpha 2.7.11.1 0.699
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.698
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.697
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.697
5eg3 ACPFibroblast growth factor receptor 2 / 0.697
2pzp ACPFibroblast growth factor receptor 2 / 0.695
1pk8 ATPSynapsin-1 / 0.694
2pyw ADPMethylthioribose kinase 2.7.1.100 0.694
2yaa ATPDeath-associated protein kinase 2 / 0.694
3c50 ADPRhodopsin kinase / 0.694
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.693
4utd ACPAurora kinase A 2.7.11.1 0.693
3bu5 ATPInsulin receptor 2.7.10.1 0.692
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.692
1mq4 ADPAurora kinase A 2.7.11.1 0.690
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.689
5drd ATPAurora kinase A 2.7.11.1 0.686
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.685
4ceg ADPAurora kinase A 2.7.11.1 0.685
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.685
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.685
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.684
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.683
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.683
4bn1 ADPAurora kinase A 2.7.11.1 0.682
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.681
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.680
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.680
5ce3 ADPProtein kinase YopO / 0.680
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.679
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.679
4dee ADPAurora kinase A 2.7.11.1 0.678
1ol6 ATPAurora kinase A 2.7.11.1 0.677
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.676
5dt3 ATPAurora kinase A 2.7.11.1 0.675
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.674
3cly ACPFibroblast growth factor receptor 2 / 0.674
4n57 ADPAPH(2'')-Id / 0.674
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.673
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.672
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.672
4q5h ANPProtein kinase OspG 2.7 0.672
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.669
5dn3 ATPAurora kinase A 2.7.11.1 0.669
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.668
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.668
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.668
5dr2 ATPAurora kinase A 2.7.11.1 0.668
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.667
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.666
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.666
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.665
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.665
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.665
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.665
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.665
5l6w AGSLIM domain kinase 1 2.7.11.1 0.665
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.664
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.664
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.663
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.663
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.662
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.661
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.659
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.659
5iqa GNPBifunctional AAC/APH 2.3.1 0.659
5l8k ADPAurora kinase A 2.7.11.1 0.659
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.658
4qny ANPMitogen activated protein kinase, putative / 0.658
4x8o AP5Adenylate kinase / 0.658
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.657
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.656
3g8c ADPBiotin carboxylase 6.3.4.14 0.656
3o0o TTPVitamin B12-dependent ribonucleotide reductase / 0.656
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.656
4o4d ATPKinase / 0.656
2j9g ADPBiotin carboxylase 6.3.4.14 0.655
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.654
1m0w ANPGlutathione synthetase 6.3.2.3 0.653
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.653
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.653
2x0q ATPAlcaligin biosynthesis protein / 0.652
2w02 ATPAcsD / 0.651
3ibq ATPPyridoxal kinase / 0.651
3ufx GDPSuccinate--CoA ligase [GDP-forming] subunit beta / 0.651
5byl GCPBifunctional AAC/APH 2.3.1 0.651
1ol7 ADPAurora kinase A 2.7.11.1 0.650
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650
4fu0 ADPD-alanine--D-alanine ligase / 0.650
5l8j ADPAurora kinase A 2.7.11.1 0.650