Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4y0k NAP AntE

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4y0k NAPAntE / 1.302
4y1b NAPAntE / 1.191
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.748
5doz NDPJamJ / 0.739
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.730
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.724
2y05 NAPProstaglandin reductase 1 / 0.696
3nx4 NAPPutative oxidoreductase / 0.696
4tvb NADHomospermidine synthase 2.5.1.44 0.696
4ejm NAPPutative zinc-binding dehydrogenase / 0.694
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.691
4oaq NDPR-specific carbonyl reductase / 0.691
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.690
4isk UMPThymidylate synthase / 0.689
4ein NOHThymidylate synthase 2.1.1.45 0.688
4xrg NADHomospermidine synthase 2.5.1.44 0.686
3jv7 NADSecondary alcohol dehydrogenase / 0.685
4xq9 NADHomospermidine synthase 2.5.1.44 0.684
1qor NDPQuinone oxidoreductase 1 / 0.683
4plp NADHomospermidine synthase 2.5.1.44 0.682
3wle NAD(R)-specific carbonyl reductase / 0.680
4k28 NADShikimate dehydrogenase family protein / 0.680
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.678
5dp2 NAPCurF / 0.677
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
5a05 NDPGlucose-fructose oxidoreductase / 0.673
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.672
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
4b7x NAPProbable oxidoreductase / 0.670
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
3ras NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.668
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.667
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.667
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.666
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.665
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.664
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.663
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.663
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.663
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.662
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.662
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.662
1ur5 NADMalate dehydrogenase / 0.662
2glx NDP1,5-anhydro-D-fructose reductase / 0.662
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.661
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.661
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.661
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.661
3keo NADRedox-sensing transcriptional repressor Rex / 0.660
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.660
3two NDPMannitol dehydrogenase / 0.660
2c29 NAPDihydroflavonol 4-reductase / 0.659
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.658
2ph5 NADHomospermidine synthase / 0.658
2rcy NAPPyrroline-5-carboxylate reductase / 0.658
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.658
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.657
1u7h NADPutative ornithine cyclodeaminase / 0.657
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.657
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.656
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.656
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.655
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.655
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.655
3tqh NDPQuinone oxidoreductase / 0.655
1yqx NAPSinapyl alcohol dehydrogenase / 0.654
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.654
2xvh NAPPutative flavin-containing monooxygenase / 0.654
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.654
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.654
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.653
2vq7 NAPPutative flavin-containing monooxygenase / 0.653
3hwr NDP2-dehydropantoate 2-reductase / 0.653
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.653
2cy0 NAPShikimate dehydrogenase (NADP(+)) / 0.652
2vna NAPProstaglandin reductase 2 1.3.1.48 0.652
2voj NADAlanine dehydrogenase 1.4.1.1 0.652
4hwk NAPSepiapterin reductase 1.1.1.153 0.652
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.651
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.651
2c0c NAPProstaglandin reductase 3 1 0.651
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.651
2ev9 NAPShikimate dehydrogenase (NADP(+)) / 0.650
2jah NDPClavaldehyde dehydrogenase / 0.650
2vq3 NAPMetalloreductase STEAP3 / 0.650
3u9e COALmo1369 protein / 0.650
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.650