Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xw6 ADP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.141
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.075
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.061
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.047
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.042
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.037
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.014
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.013
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.010
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.006
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.005
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.005
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.005
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.997
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.983
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.943
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.940
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.921
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.920
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.915
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.911
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.902
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.891
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.887
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.875
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.866
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.860
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.854
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.853
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.848
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.828
4ysj ADPCalmodulin-like domain protein kinase / 0.827
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.824
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.814
4ceg ADPAurora kinase A 2.7.11.1 0.814
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.805
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.804
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.802
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.802
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.801
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.798
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.794
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.794
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.792
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.789
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.787
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.783
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.782
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.781
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.781
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.777
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.777
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.774
1mq4 ADPAurora kinase A 2.7.11.1 0.773
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.771
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.771
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.771
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.770
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.767
3c4z ADPRhodopsin kinase / 0.767
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.767
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.766
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.766
2pyw ADPMethylthioribose kinase 2.7.1.100 0.765
5dn3 ATPAurora kinase A 2.7.11.1 0.765
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.763
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.763
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.762
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.757
3qc9 ADPRhodopsin kinase / 0.757
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.755
5dos ATPAurora kinase A 2.7.11.1 0.754
5dr2 ATPAurora kinase A 2.7.11.1 0.754
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.753
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.752
4ork GDPBifunctional AAC/APH 2.3.1 0.752
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.751
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.751
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.750
4dee ADPAurora kinase A 2.7.11.1 0.750
4utd ACPAurora kinase A 2.7.11.1 0.750
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.749
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.749
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
5dt3 ATPAurora kinase A 2.7.11.1 0.747
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.745
3cly ACPFibroblast growth factor receptor 2 / 0.743
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.742
3c50 ADPRhodopsin kinase / 0.739
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.739
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.739
5drd ATPAurora kinase A 2.7.11.1 0.739
4qny ANPMitogen activated protein kinase, putative / 0.738
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.737
5dnr ATPAurora kinase A 2.7.11.1 0.736
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.735
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.734
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.733
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.733
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.733
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.732
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.732
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.732
2pup ADPMethylthioribose kinase 2.7.1.100 0.728
5iqh GNPBifunctional AAC/APH 2.3.1 0.726
2pui ADPMethylthioribose kinase 2.7.1.100 0.724
5dt4 ATPAurora kinase A 2.7.11.1 0.724
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.722
5ce3 ADPProtein kinase YopO / 0.721
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.720
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.720
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.719
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.719
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.719
3t8o ATPRhodopsin kinase / 0.719
5iqf GDPBifunctional AAC/APH 2.3.1 0.717
1pk8 ATPSynapsin-1 / 0.716
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.715
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.711
4bn1 ADPAurora kinase A 2.7.11.1 0.711
4gyi ADPUncharacterized protein / 0.711
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.710
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.706
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.705
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.704
4n57 ADPAPH(2'')-Id / 0.704
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.703
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.703
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.702
1m0w ANPGlutathione synthetase 6.3.2.3 0.701
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.701
3tdw GDPGentamicin resistance protein / 0.701
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.701
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.700
2zdg ADPD-alanine--D-alanine ligase / 0.700
3nie ANPMitogen-activated protein kinase / 0.700
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.699
3wo0 ADPAlanine--anticapsin ligase / 0.699
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.699
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.698
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.697
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.697
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.696
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.696
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.695
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.693
4o4d ATPKinase / 0.693
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.691
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.691
3ori AGSSerine/threonine protein kinase / 0.691
5iqb GNPBifunctional AAC/APH 2.3.1 0.691
3orp AGSSerine/threonine protein kinase / 0.690
5iqe GNPBifunctional AAC/APH 2.3.1 0.690
2pul ACPMethylthioribose kinase 2.7.1.100 0.689
1ol6 ATPAurora kinase A 2.7.11.1 0.688
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.687
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.686
2j9g ADPBiotin carboxylase 6.3.4.14 0.684
2olc ADPMethylthioribose kinase 2.7.1.100 0.684
5iqi GNPBifunctional AAC/APH 2.3.1 0.684
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.683
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
4o0w ADNAurora kinase A 2.7.11.1 0.681
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.679
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.678
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.678
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.678
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.678
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.678
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.677
3c4w ATPRhodopsin kinase / 0.677
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.676
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.676
3tdv GDPGentamicin resistance protein / 0.676
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.675
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.675
3iew CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.674
3ort AGSSerine/threonine protein kinase / 0.674
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
2pzp ACPFibroblast growth factor receptor 2 / 0.673
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.673
3orm AGSSerine/threonine protein kinase / 0.673
3oro AGSSerine/threonine protein kinase / 0.673
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.673
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.673
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.673
5byl GCPBifunctional AAC/APH 2.3.1 0.673
1mjh ATPUniversal stress protein MJ0577 / 0.672
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.672
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.672
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.672
5iqg GDPBifunctional AAC/APH 2.3.1 0.672
2wqe ADPAurora kinase A 2.7.11.1 0.671
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.670
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.669
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.669
3bu5 ATPInsulin receptor 2.7.10.1 0.669
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
5iqa GNPBifunctional AAC/APH 2.3.1 0.668
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.667
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.665
2vqd AP2Biotin carboxylase 6.3.4.14 0.664
2qdx FADFerredoxin--NADP+ reductase / 0.663
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.663
4o1p ANPRibonuclease L / 0.663
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.662
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.661
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.661
2qen ADPWalker-Type ATPase / 0.660
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.659
3pff ADPATP-citrate synthase 2.3.3.8 0.659
2hgs ADPGlutathione synthetase 6.3.2.3 0.658
2py3 ACPFibroblast growth factor receptor 2 / 0.658
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.658
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.657
2emu SAHDiphthine synthase / 0.657
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.657
3g8c ADPBiotin carboxylase 6.3.4.14 0.657
4s26 SAHPhosphomethylpyrimidine synthase, chloroplastic 4.1.99.17 0.657
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.656
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.656
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.655
4o0s ADNAurora kinase A 2.7.11.1 0.655
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
4l2i FADElectron transfer flavoprotein alpha/beta-subunit / 0.654
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.654
4xlv ACPInsulin receptor 2.7.10.1 0.654
2pz5 ACPFibroblast growth factor receptor 2 / 0.653
3c4x ATPRhodopsin kinase / 0.653
4ffr ATPUncharacterized protein / 0.653
5l8l ADPAurora kinase A 2.7.11.1 0.653
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.651
4j98 ACPFibroblast growth factor receptor 2 / 0.651
2el3 SAHDiphthine synthase / 0.650
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.650
4rz3 ADPSite-determining protein / 0.650