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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xc0 ACP Heat shock cognate 90 kDa protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xc0 ACPHeat shock cognate 90 kDa protein / 0.908
3t10 ACPHeat shock protein HSP 90-alpha / 0.871
3t1k ANPHeat shock protein HSP 90-alpha / 0.860
4xcl AGSHeat shock cognate 90 kDa protein / 0.837
4xcj ADPHeat shock cognate 90 kDa protein / 0.835
2yef ANPHeat shock protein HSP 90-alpha / 0.827
4gqt ADPHeat shock protein 90 / 0.819
3t0z ATPHeat shock protein HSP 90-alpha / 0.812
3t2s AGSHeat shock protein HSP 90-alpha / 0.811
2xk2 ADPHeat shock protein HSP 90-alpha / 0.796
2ior ADPChaperone protein HtpG / 0.790
4ivg ANPTNF receptor-associated protein 1 / 0.781
4wuc ANPDNA gyrase subunit B / 0.781
1byq ADPHeat shock protein HSP 90-alpha / 0.780
4ipe ANPTNF receptor-associated protein 1 / 0.775
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.771
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.767
4wud ANPDNA gyrase subunit B / 0.761
1yt0 ADPEndoplasmin / 0.759
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.740
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.733
2xcm ADPCytosolic heat shock protein 90 / 0.729
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.726
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.726
2o1u ANPEndoplasmin / 0.721
2wep ADPATP-dependent molecular chaperone HSP82 / 0.711
1amw ADPATP-dependent molecular chaperone HSP82 / 0.710
1nhh ANPDNA mismatch repair protein MutL / 0.710
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.708
4gt8 ADPSensor protein VraS 2.7.13.3 0.708
3sl2 ATPSensor histidine kinase WalK / 0.705
1y4s ADPChaperone protein HtpG / 0.703
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.702
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.694
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.693
3ied AN2HSP90 / 0.692
4prx ADPDNA gyrase subunit B / 0.692
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.690
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.690
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.687
3a0t ADPSensor histidine kinase / 0.684
4r3a ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.684
4prv ADPDNA gyrase subunit B / 0.683
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.681
1th8 ADPAnti-sigma F factor / 0.680
1s16 ANPDNA topoisomerase 4 subunit B / 0.678
2o1v ADPEndoplasmin / 0.676
3zkb ANPDNA gyrase subunit B / 0.676
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.676
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.673
4bix ADPSensor histidine kinase CpxA / 0.672
3zkd ANPDNA gyrase subunit B / 0.669
4col DTPUncharacterized protein / 0.663
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.662
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.662
2yeg XQGHeat shock protein HSP 90-alpha / 0.656
1zxn ADPDNA topoisomerase 2-alpha 5.99.1.3 0.655
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.654
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.653
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.651
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.651
3w0p ADPHygromycin-B 4-O-kinase 2.7.1.163 0.651
4xfj ANPArgininosuccinate synthase / 0.651
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.650