Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fvr ATP Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fvr ATPTyrosine-protein kinase JAK2 / 1.239
5i4n ATPTyrosine-protein kinase JAK2 / 1.132
4fvq ATPTyrosine-protein kinase JAK2 / 1.058
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.832
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.740
4qm6 GTPMetallophosphoesterase / 0.713
3mhy ATPNitrogen regulatory protein P-II 1 / 0.700
3ta2 ATPNitrogen regulatory protein P-II (GlnB-3) / 0.700
1n2e APCPantothenate synthetase 6.3.2.1 0.698
1xbt TTPThymidine kinase, cytosolic 2.7.1.21 0.697
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.694
2q16 ITTdITP/XTP pyrophosphatase / 0.693
1r0z ATPCystic fibrosis transmembrane conductance regulator / 0.692
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.692
2xul ATPNitrogen regulatory protein P-II / 0.690
4df8 0L4DNA polymerase I, thermostable 2.7.7.7 0.686
3er9 3ATPoly(A) polymerase catalytic subunit 2.7.7.19 0.684
3dt2 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.682
3dt4 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.682
1mab ATPATP synthase subunit alpha, mitochondrial / 0.681
1n2g APCPantothenate synthetase 6.3.2.1 0.680
1u0h GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.679
2uyi ADPKinesin-like protein KIF11 / 0.679
1sxj AGSReplication factor C subunit 1 / 0.677
4tyq AP5Adenylate kinase / 0.676
3dkv AP5Adenylate kinase / 0.675
4a28 ADPKinesin-like protein KIF11 / 0.675
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.674
4ix6 ADPUncharacterized protein / 0.674
4r43 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.674
3v2u ATPProtein GAL3 / 0.672
4ffb GTPTubulin alpha-1 chain / 0.672
4xj4 3ATCyclic GMP-AMP synthase / 0.672
4tla ADPCircadian clock protein kinase KaiC 2.7.11.1 0.671
4wbn GTPTubulin alpha-1B chain / 0.671
2olr ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.670
1svm ATPLarge T antigen 3.6.4 0.669
3n0y APCAdenylate cyclase 2 / 0.669
4mkg AP5Adenylate kinase / 0.669
3m0e ATPTranscriptional regulator (NtrC family) / 0.668
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.667
1mez GDPAdenylosuccinate synthetase isozyme 1 / 0.666
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.666
2whx ADPGenome polyprotein 3.4.21.91 0.666
5itz GTPTubulin alpha-1B chain / 0.665
2vp4 DCPDeoxynucleoside kinase / 0.664
4iij GTPTubulin alpha-1B chain / 0.664
5cns DATRibonucleoside-diphosphate reductase 1 subunit alpha 1.17.4.1 0.664
3wyg GTPGTP-binding nuclear protein GSP1/CNR1 / 0.663
4jl8 ADPAdenylate kinase / 0.663
4m3t ATPDNA-directed DNA polymerase / 0.663
1yxq ATPActin, alpha skeletal muscle / 0.662
2rgx AP5Adenylate kinase / 0.662
3a5m ATPMajor actin / 0.662
2xau ADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 3.6.4.13 0.661
1mmg AGSMyosin-2 heavy chain / 0.660
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.660
1xnj ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.7.1.25 0.660
2wgh DTPRibonucleoside-diphosphate reductase large subunit 1.17.4.1 0.660
4ihq ADPConserved Archaeal protein / 0.660
3dl0 AP5Adenylate kinase / 0.659
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.659
4asu ADPATP synthase subunit alpha, mitochondrial / 0.659
4oi4 ATPmRNA cleavage and polyadenylation factor CLP1 / 0.659
4dvg GSPRho family GTPase / 0.658
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.657
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.657
1w0k ADPATP synthase subunit alpha, mitochondrial / 0.657
1w0k ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.657
1ih8 APCNH(3)-dependent NAD(+) synthetase 6.3.1.5 0.656
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.656
1xef ATPAlpha-hemolysin translocation ATP-binding protein HlyB / 0.656
2qaj AP5Adenylate kinase / 0.656
2we3 DUTDeoxyuridine 5'-triphosphate nucleotidohydrolase / 0.656
4dxj 0M9Farnesyl pyrophosphate synthase / 0.656
4ncl GDPEukaryotic translation initiation factor 5B / 0.656
4tl7 ATPCircadian clock protein kinase KaiC 2.7.11.1 0.656
1l8q ADPChromosomal replication initiator protein DnaA / 0.655
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.655
3sl2 ATPSensor histidine kinase WalK / 0.655
4itr GDPCell division control protein 42 homolog / 0.655
4ww0 ADPATP-dependent zinc metalloprotease FtsH / 0.655
1h65 GDPTranslocase of chloroplast 34 3.6.5 0.654
1jx2 ADPMyosin-2 heavy chain / 0.654
2pg2 ADPKinesin-like protein KIF11 / 0.654
2xae ADPKinesin-like protein KIF11 / 0.654
4a6a TTPdCTP deaminase 3.5.4.13 0.654
2x2r ADPKinesin-like protein KIF11 / 0.653
3bb3 GDPTranslocase of chloroplast 33, chloroplastic 3.6.5 0.653
3kuc GDPRas-related protein Rap-1A / 0.653
3ork AGSSerine/threonine protein kinase / 0.653
4pk4 ADPUnconventional myosin-VI / 0.653
4y9x UPGGlucosyl-3-phosphoglycerate synthase 2.4.1.266 0.653
1xs4 DCPdCTP deaminase / 0.652
2dpx GDPGTP-binding protein RAD / 0.652
2gvd GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.652
3x1w GDPRas-related protein Rap-1b / 0.652
2cvx DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.651
2v7t SAH5'-fluoro-5'-deoxy-adenosine synthase / 0.651
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.651
3w3z GTPGTP-binding nuclear protein Ran / 0.651
4dca ADPAminoglycoside phosphotransferase / 0.651
4ldj GDPGTPase KRas / 0.651
5jqg GTPTubulin alpha-1B chain / 0.651
1h8h ATPATP synthase subunit alpha, mitochondrial / 0.650
1h8h ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.650
3wyf GTPGTP-binding nuclear protein / 0.650
4ag5 ADPType IV secretory pathway VirB4 components-like protein / 0.650
4dtp DGTDNA-directed DNA polymerase / 0.650
4tlc AGSCircadian clock protein kinase KaiC 2.7.11.1 0.650
4wuc ANPDNA gyrase subunit B / 0.650