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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c4o NAD SADH

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c4o NADSADH / 1.205
3wle NAD(R)-specific carbonyl reductase / 1.050
3jv7 NADSecondary alcohol dehydrogenase / 0.964
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.949
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.934
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.909
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.906
2xaa NADSecondary alcohol dehydrogenase / 0.900
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.897
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.894
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.891
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.888
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.874
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.874
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.873
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.873
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.869
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.869
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.868
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.863
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.861
3two NDPMannitol dehydrogenase / 0.861
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.860
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.858
4oaq NDPR-specific carbonyl reductase / 0.856
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.853
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.853
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.851
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.848
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.845
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.842
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.840
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.838
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.837
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.837
1uxj NADMalate dehydrogenase / 0.830
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.830
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.826
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.824
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.821
1yqd NAPSinapyl alcohol dehydrogenase / 0.819
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.818
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.811
4j43 NADUncharacterized protein / 0.809
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.808
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.804
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.803
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.803
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.802
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.796
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.792
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.791
4j49 NADUncharacterized protein / 0.790
4jk3 NADUncharacterized protein / 0.790
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.785
1o6z NADMalate dehydrogenase / 0.779
3wsw NADL-lactate dehydrogenase / 0.772
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.771
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.767
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.766
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.765
1uxk NADMalate dehydrogenase / 0.764
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.762
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.761
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.754
1u7h NADPutative ornithine cyclodeaminase / 0.753
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.753
4j4b NAIUncharacterized protein / 0.747
1yqx NAPSinapyl alcohol dehydrogenase / 0.746
4rqu NADAlcohol dehydrogenase class-P / 0.746
1ib6 NADMalate dehydrogenase / 0.743
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.743
2x0i NAIMalate dehydrogenase / 0.742
4cpd NADAlcohol dehydrogenase / 0.742
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
1sow NADL-lactate dehydrogenase 1.1.1.27 0.741
2vhx NADAlanine dehydrogenase 1.4.1.1 0.739
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.738
2voj NADAlanine dehydrogenase 1.4.1.1 0.738
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.737
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.735
1llu NADAlcohol dehydrogenase / 0.732
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.730
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.729
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.729
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.726
4i1i NADMalate dehydrogenase / 0.725
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.724
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.723
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.718
2dph NADFormaldehyde dismutase / 0.718
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.718
1hku NADC-terminal-binding protein 1 1.1.1 0.716
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.713
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.713
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.712
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.712
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.709
2dc1 NADProbable L-aspartate dehydrogenase / 0.708
1pjc NADAlanine dehydrogenase / 0.705
4b7x NAPProbable oxidoreductase / 0.705
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.705
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.703
1x7d NADPutative ornithine cyclodeaminase / 0.702
2vwh NAPGlucose 1-dehydrogenase / 0.702
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.701
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.701
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.701
4j49 NAIUncharacterized protein / 0.700
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.699
2g5c NADPrephenate dehydrogenase / 0.699
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.698
1zmd NAIDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.697
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.694
3kb6 NADD-lactate dehydrogenase / 0.690
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.688
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.688
4hb9 FADUncharacterized protein / 0.688
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.688
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.687
5a02 NAPGlucose-fructose oxidoreductase / 0.686
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.685
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.685
1c1d NAIPhenylalanine dehydrogenase / 0.684
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.684
2gsd NADFormate dehydrogenase / 0.684
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.683
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.682
3tsc NADUncharacterized protein / 0.682
2dbz NAPGlyoxylate reductase 1.1.1.26 0.681
1gv0 NADMalate dehydrogenase / 0.680
1p1i NADInositol-3-phosphate synthase 5.5.1.4 0.679
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.679
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.679
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.678
4egb NADdTDP-glucose 4,6-dehydratase / 0.678
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.677
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.676
3wds NADNADH-dependent quinuclidinone reductase / 0.676
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.675
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.675
4xye NADFormate dehydrogenase / 0.675
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.674
4gl4 NAIAlcohol dehydrogenase class-3 / 0.674
4l0q NADAlcohol dehydrogenase class-3 / 0.674
3x2e NAIAdenosylhomocysteinase / 0.673
1ie3 NADMalate dehydrogenase / 0.671
2o4c NADErythronate-4-phosphate dehydrogenase / 0.671
4jji NADAlcohol dehydrogenase class-3 / 0.671
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.670
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.670
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.670
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.669
2nad NADFormate dehydrogenase / 0.669
3orf NADDihydropteridine reductase 1.5.1.34 0.669
4a99 FADTetX family tetracycline inactivation enzyme / 0.669
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.668
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.668
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.668
1bmd NADMalate dehydrogenase / 0.667
2aa3 AP0L-lactate dehydrogenase / 0.667
2w2l NADD-mandelate dehydrogenase / 0.666
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.665
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.665
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.665
1b8u NADMalate dehydrogenase / 0.664
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.664
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.663
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.662
2d8a NADL-threonine 3-dehydrogenase / 0.661
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.661
2x0r NADMalate dehydrogenase / 0.661
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.660
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.660
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.659
1xcb NADRedox-sensing transcriptional repressor Rex / 0.659
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.659
5dp2 NAPCurF / 0.659
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.658
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.658
4weq NAPNAD-dependent dehydrogenase / 0.658
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.658
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.656
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.656
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.655
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.655
2dfv NADL-threonine 3-dehydrogenase / 0.655
3wv7 ADPHmd co-occurring protein HcgE / 0.655
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.654
3ikt NADRedox-sensing transcriptional repressor Rex / 0.654
3rfx NADUronate dehydrogenase / 0.654
3tqh NDPQuinone oxidoreductase / 0.653
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.653
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.653
1bw9 NADPhenylalanine dehydrogenase / 0.652
1xq6 NAPUncharacterized protein At5g02240 / 0.652
2hmv ADPKtr system potassium uptake protein A / 0.651
2npx NADNADH peroxidase 1.11.1.1 0.650
2p5y NADUDP-glucose 4-epimerase / 0.650
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.650
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.650