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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uko NAD Alcohol dehydrogenase class-3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uko NADAlcohol dehydrogenase class-3 / 1.112
4jji NADAlcohol dehydrogenase class-3 / 0.979
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.934
4l0q NADAlcohol dehydrogenase class-3 / 0.926
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.901
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.873
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.867
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.853
4gl4 NAIAlcohol dehydrogenase class-3 / 0.826
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.818
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.804
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.796
2vhx NADAlanine dehydrogenase 1.4.1.1 0.774
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.772
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.763
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.754
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.747
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.745
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.744
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.740
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.739
3wsw NADL-lactate dehydrogenase / 0.739
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.733
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.732
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.732
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.732
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.730
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.727
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.726
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.724
1qlh NADAlcohol dehydrogenase E chain 1.1.1.1 0.724
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.724
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
3wle NAD(R)-specific carbonyl reductase / 0.721
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.720
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.720
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.719
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
4rqu NADAlcohol dehydrogenase class-P / 0.719
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.717
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.716
1uxk NADMalate dehydrogenase / 0.714
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.713
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.713
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.711
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.711
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.709
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.707
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.707
2yy7 NADL-threonine dehydrogenase / 0.707
4oaq NDPR-specific carbonyl reductase / 0.706
2g5c NADPrephenate dehydrogenase / 0.702
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.701
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.701
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.697
1o6z NADMalate dehydrogenase / 0.695
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.695
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.695
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.695
1guy NADMalate dehydrogenase / 0.694
2d8a NADL-threonine 3-dehydrogenase / 0.693
2dph NADFormaldehyde dismutase / 0.692
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.691
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.690
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.689
3ggp NADPrephenate dehydrogenase / 0.689
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.689
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.688
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.684
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.684
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.684
1uxj NADMalate dehydrogenase / 0.684
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.683
4wct FADFructosyl amine:oxygen oxidoreductase / 0.682
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.680
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.680
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.680
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.680
1llu NADAlcohol dehydrogenase / 0.679
2voj NADAlanine dehydrogenase 1.4.1.1 0.679
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.679
4weq NAPNAD-dependent dehydrogenase / 0.679
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.678
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.677
1f8f NADBenzyl alcohol dehydrogenase / 0.676
4i1i NADMalate dehydrogenase / 0.675
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.674
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.674
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.673
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.673
3ggo NAIPrephenate dehydrogenase / 0.673
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.673
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.672
2x0i NAIMalate dehydrogenase / 0.672
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.672
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
4cpd NADAlcohol dehydrogenase / 0.670
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.670
3jv7 NADSecondary alcohol dehydrogenase / 0.669
3ptz NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.669
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.667
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.667
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.667
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.667
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.665
1bw9 NADPhenylalanine dehydrogenase / 0.664
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.664
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.663
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.663
4z0p NDPNAD-dependent dehydrogenase / 0.663
1c1d NAIPhenylalanine dehydrogenase / 0.662
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.662
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.662
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.662
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.662
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.662
1yqd NAPSinapyl alcohol dehydrogenase / 0.661
2cdc NAPGlucose 1-dehydrogenase / 0.661
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.660
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.660
3d64 NADAdenosylhomocysteinase / 0.660
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.660
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.660
4k28 NADShikimate dehydrogenase family protein / 0.659
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.659
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.658
1ptj SNDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.658
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
1wze NADMalate dehydrogenase / 0.657
3m2t NADProbable dehydrogenase / 0.657
4tm3 FADKtzI / 0.657
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.657
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
4j49 NADUncharacterized protein / 0.656
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.655
1sow NADL-lactate dehydrogenase 1.1.1.27 0.655
3ksd NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.655
4xr9 NADCalS8 / 0.655
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.654
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.653
1zem NADXylitol dehydrogenase / 0.653
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.653
1bmd NADMalate dehydrogenase / 0.652
1dap NDPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.652
1ur5 NADMalate dehydrogenase / 0.652
2cda NAPGlucose 1-dehydrogenase / 0.652
4j43 NADUncharacterized protein / 0.652
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.651
1zmd NAIDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.651
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.650
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.650
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.650
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.650
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.650
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.650
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.650
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.650