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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3a7h ATP Serine/threonine-protein kinase 24 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.840
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.734
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.733
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.729
5ckw ANPUncharacterized protein / 0.721
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.715
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.713
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.710
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.705
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.705
4wzy ATPMaltokinase 2.7.1.175 0.701
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.694
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.694
4qny ANPMitogen activated protein kinase, putative / 0.693
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.689
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.688
2pul ACPMethylthioribose kinase 2.7.1.100 0.686
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.683
5eg3 ACPFibroblast growth factor receptor 2 / 0.683
3t8o ATPRhodopsin kinase / 0.682
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.681
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.680
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.679
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.678
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.677
3rv4 ADPBiotin carboxylase 6.3.4.14 0.677
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.676
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.676
4xlv ACPInsulin receptor 2.7.10.1 0.676
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.675
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1u54 ACPActivated CDC42 kinase 1 / 0.674
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.673
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.673
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.671
1ol6 ATPAurora kinase A 2.7.11.1 0.670
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.670
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.670
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.668
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
2oli IOPBasic phospholipase A2 VRV-PL-VIIIa 3.1.1.4 0.666
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.665
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
1e8x ATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.664
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.664
2olc ADPMethylthioribose kinase 2.7.1.100 0.664
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.664
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.663
2pup ADPMethylthioribose kinase 2.7.1.100 0.663
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.663
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.663
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.662
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.661
4mv8 ACPBiotin carboxylase 6.3.4.14 0.661
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.660
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.660
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.660
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.659
1ad5 ANPTyrosine-protein kinase HCK 2.7.10.2 0.658
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.658
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.658
1wbp ADPSRSF protein kinase 1 2.7.11.1 0.657
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.657
2pui ADPMethylthioribose kinase 2.7.1.100 0.657
2yaa ATPDeath-associated protein kinase 2 / 0.657
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.656
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.655
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
3mwu BK3Calmodulin-domain protein kinase 1, putative / 0.655
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.654
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.654
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.651
4tnb SGVG protein-coupled receptor kinase 5 2.7.11.16 0.651
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.650
5dnr ATPAurora kinase A 2.7.11.1 0.650