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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xcm ADP Cytosolic heat shock protein 90

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xcm ADPCytosolic heat shock protein 90 / 0.892
2xk2 ADPHeat shock protein HSP 90-alpha / 0.796
4gqt ADPHeat shock protein 90 / 0.783
4xcj ADPHeat shock cognate 90 kDa protein / 0.778
3t2s AGSHeat shock protein HSP 90-alpha / 0.775
4prx ADPDNA gyrase subunit B / 0.767
3t0z ATPHeat shock protein HSP 90-alpha / 0.766
3t10 ACPHeat shock protein HSP 90-alpha / 0.753
4xcl AGSHeat shock cognate 90 kDa protein / 0.747
1yt0 ADPEndoplasmin / 0.743
2yef ANPHeat shock protein HSP 90-alpha / 0.740
3t1k ANPHeat shock protein HSP 90-alpha / 0.735
4prv ADPDNA gyrase subunit B / 0.733
4xc0 ACPHeat shock cognate 90 kDa protein / 0.729
4ivg ANPTNF receptor-associated protein 1 / 0.720
2ior ADPChaperone protein HtpG / 0.717
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.711
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.711
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.709
1y4s ADPChaperone protein HtpG / 0.705
2o1u ANPEndoplasmin / 0.703
4wuc ANPDNA gyrase subunit B / 0.703
3ied AN2HSP90 / 0.693
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.691
2wep ADPATP-dependent molecular chaperone HSP82 / 0.688
3h4l ANPDNA mismatch repair protein PMS1 / 0.687
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.686
1amw ADPATP-dependent molecular chaperone HSP82 / 0.685
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.685
4wud ANPDNA gyrase subunit B / 0.684
1zxn ADPDNA topoisomerase 2-alpha 5.99.1.3 0.683
1byq ADPHeat shock protein HSP 90-alpha / 0.682
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.678
4ipe ANPTNF receptor-associated protein 1 / 0.677
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.674
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.670
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.666
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.666
1th8 ADPAnti-sigma F factor / 0.665
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.661
2o1v ADPEndoplasmin / 0.659
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.659
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.657
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.656
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.654
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.653