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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2py3 ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2py3 ACPFibroblast growth factor receptor 2 / 1.042
2pzp ACPFibroblast growth factor receptor 2 / 1.018
2pz5 ACPFibroblast growth factor receptor 2 / 1.001
3cly ACPFibroblast growth factor receptor 2 / 0.890
4o4d ATPKinase / 0.806
2pul ACPMethylthioribose kinase 2.7.1.100 0.790
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.786
5eg3 ACPFibroblast growth factor receptor 2 / 0.785
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.762
1m0w ANPGlutathione synthetase 6.3.2.3 0.758
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.755
2pun ACPMethylthioribose kinase 2.7.1.100 0.755
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.751
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.750
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.742
2pyw ADPMethylthioribose kinase 2.7.1.100 0.740
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.738
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.736
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.733
4bn1 ADPAurora kinase A 2.7.11.1 0.733
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.732
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.730
3bu5 ATPInsulin receptor 2.7.10.1 0.729
4gyi ADPUncharacterized protein / 0.727
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.726
3qc9 ADPRhodopsin kinase / 0.723
1u54 ACPActivated CDC42 kinase 1 / 0.722
3nie ANPMitogen-activated protein kinase / 0.722
4dee ADPAurora kinase A 2.7.11.1 0.722
3t8o ATPRhodopsin kinase / 0.721
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
3ori AGSSerine/threonine protein kinase / 0.720
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.719
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.718
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.717
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.716
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.716
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.715
2pup ADPMethylthioribose kinase 2.7.1.100 0.715
3rv4 ADPBiotin carboxylase 6.3.4.14 0.715
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.715
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.714
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.713
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.712
4ceg ADPAurora kinase A 2.7.11.1 0.712
2dwb ANPAurora kinase A 2.7.11.1 0.711
4j98 ACPFibroblast growth factor receptor 2 / 0.711
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.709
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.709
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.708
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.708
5iqh GNPBifunctional AAC/APH 2.3.1 0.708
4xlv ACPInsulin receptor 2.7.10.1 0.707
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.706
4jrn ANPRhoptry kinase family protein / 0.706
3c4z ADPRhodopsin kinase / 0.703
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.703
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.702
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.702
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.702
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.701
5dt3 ATPAurora kinase A 2.7.11.1 0.701
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.700
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.700
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.700
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.699
2pui ADPMethylthioribose kinase 2.7.1.100 0.699
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.698
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.697
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.695
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.694
1mq4 ADPAurora kinase A 2.7.11.1 0.693
5byl GCPBifunctional AAC/APH 2.3.1 0.693
3c4w ATPRhodopsin kinase / 0.692
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.692
5l8j ADPAurora kinase A 2.7.11.1 0.692
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.688
3tw6 ADPPyruvate carboxylase / 0.688
1ol6 ATPAurora kinase A 2.7.11.1 0.686
3c50 ADPRhodopsin kinase / 0.686
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.686
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.685
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
5drd ATPAurora kinase A 2.7.11.1 0.684
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4utd ACPAurora kinase A 2.7.11.1 0.683
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.682
5dr2 ATPAurora kinase A 2.7.11.1 0.682
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.681
2zdg ADPD-alanine--D-alanine ligase / 0.681
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.680
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.679
4j97 ACPFibroblast growth factor receptor 2 / 0.679
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.678
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.676
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.676
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.675
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.673
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.673
2j9g ADPBiotin carboxylase 6.3.4.14 0.673
2vqd AP2Biotin carboxylase 6.3.4.14 0.673
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.673
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.673
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5dn3 ATPAurora kinase A 2.7.11.1 0.673
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2pml ANPUncharacterized protein / 0.671
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.669
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.669
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.668
4uux APRCinA-like protein / 0.667
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.666
3b2t M33Fibroblast growth factor receptor 2 / 0.666
5l8l ADPAurora kinase A 2.7.11.1 0.666
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
2pvy ACPFibroblast growth factor receptor 2 / 0.665
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.665
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
5dos ATPAurora kinase A 2.7.11.1 0.664
5iqb GNPBifunctional AAC/APH 2.3.1 0.664
3g8c ADPBiotin carboxylase 6.3.4.14 0.663
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.663
4db1 ANPMyosin-7 / 0.663
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.662
3q5i ANPProtein kinase, putative / 0.662
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.661
3llt ANPProtein serine/threonine kinase-1 / 0.661
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.661
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.660
4n57 ADPAPH(2'')-Id / 0.660
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.659
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.659
3ll9 ADPIsopentenyl phosphate kinase / 0.659
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.658
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1ol5 ADPAurora kinase A 2.7.11.1 0.657
2olc ADPMethylthioribose kinase 2.7.1.100 0.657
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.657
5ce3 ADPProtein kinase YopO / 0.657
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.656
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.656
3c4x ATPRhodopsin kinase / 0.655
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.654
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.653
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.653
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.653
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.653
1ir3 ANPInsulin receptor 2.7.10.1 0.652
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.652
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.650
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.650
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.650
3hdy GDUUDP-galactopyranose mutase / 0.650