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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fkn NAD Urocanate hydratase 4.2.1.49

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fkn NADUrocanate hydratase 4.2.1.49 1.358
2v7g NADUrocanate hydratase 4.2.1.49 1.105
4jk3 NADUncharacterized protein / 0.741
1g1a NADdTDP-glucose 4,6-dehydratase / 0.722
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.714
5bxy SAHPutative RNA methylase family UPF0020 / 0.711
4o29 SAHProtein-L-isoaspartate O-methyltransferase / 0.705
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.704
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.704
3wv8 ATPHmd co-occurring protein HcgE / 0.702
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.701
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.700
2qe6 SAMUncharacterized protein / 0.700
4j49 NADUncharacterized protein / 0.700
4fp9 SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.697
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.697
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
3wv7 ADPHmd co-occurring protein HcgE / 0.695
2gsd NADFormate dehydrogenase / 0.694
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.691
4j4b NAIUncharacterized protein / 0.691
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.691
2o06 MTASpermidine synthase 2.5.1.16 0.690
1kr5 SAHProtein-L-isoaspartate(D-aspartate) O-methyltransferase 2.1.1.77 0.688
3ssm SAHMycinamicin VI 2''-O-methyltransferase / 0.688
4id9 NADPutative UDP-glucose 4-epimerase / 0.688
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.688
2yqz SAMUncharacterized protein / 0.687
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.686
3wmx NADNAD dependent epimerase/dehydratase / 0.686
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.685
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.684
1x7d NADPutative ornithine cyclodeaminase / 0.684
1pjc NADAlanine dehydrogenase / 0.683
1skm SAHModification methylase HhaI 2.1.1.37 0.683
4yac NAIC alpha-dehydrogenase / 0.683
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.683
2rgj FADFlavin-containing monooxygenase / 0.682
2c7q SAHModification methylase HhaI 2.1.1.37 0.681
2vhx NADAlanine dehydrogenase 1.4.1.1 0.681
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.681
3go4 SAHUncharacterized protein / 0.681
4iwn GEKCarboxy-S-adenosyl-L-methionine synthase / 0.681
4plp NADHomospermidine synthase 2.5.1.44 0.681
1o9b NAIQuinate/shikimate dehydrogenase / 0.680
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.680
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.680
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.680
1c1d NAIPhenylalanine dehydrogenase / 0.678
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.678
3ak4 NADNADH-dependent quinuclidinone reductase / 0.678
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.678
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.678
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.677
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.677
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.676
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.676
2x0i NAIMalate dehydrogenase / 0.676
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.674
3bgv SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.674
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.674
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.672
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.672
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.672
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.672
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.671
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.671
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
1u7h NADPutative ornithine cyclodeaminase / 0.670
2pv7 NADT-protein 1.3.1.12 0.670
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.669
2p35 SAHTrans-aconitate 2-methyltransferase / 0.669
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.669
4tvb NADHomospermidine synthase 2.5.1.44 0.669
3ec7 NADInositol 2-dehydrogenase / 0.668
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.668
3e8s SAHUncharacterized protein / 0.667
3ldg SAHUncharacterized protein / 0.667
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.666
3gvi ADPMalate dehydrogenase / 0.666
3iei SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.666
3ou6 SAMSAM-dependent methyltransferase / 0.666
4j49 NAIUncharacterized protein / 0.666
1llu NADAlcohol dehydrogenase / 0.665
4yv2 S4MSpermidine synthase, putative / 0.665
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.664
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.664
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.664
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.663
4xrg NADHomospermidine synthase 2.5.1.44 0.663
1y9d FADPyruvate oxidase 1.2.3.3 0.662
3fpf MTAUncharacterized protein / 0.662
4xq9 NADHomospermidine synthase 2.5.1.44 0.661
2o4c NADErythronate-4-phosphate dehydrogenase / 0.660
3lcc SAHThiocyanate methyltransferase 1 / 0.660
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
4xqc NADHomospermidine synthase 2.5.1.44 0.660
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.659
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.659
3lhd SAHtRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI 2.1.1.219 0.659
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.659
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.659
4j43 NADUncharacterized protein / 0.659
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.659
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.659
1uxj NADMalate dehydrogenase / 0.658
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.658
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.658
3abi NADUncharacterized protein / 0.656
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.655
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.655
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.655
3dmh SAMProbable ribosomal RNA small subunit methyltransferase / 0.655
1gv0 NADMalate dehydrogenase / 0.654
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.654
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.654
2np7 NEAModification methylase TaqI 2.1.1.72 0.654
2voj NADAlanine dehydrogenase 1.4.1.1 0.654
3p2e SAH16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.654
1qao SAMrRNA adenine N-6-methyltransferase 2.1.1.184 0.653
4yv0 S4MSpermidine synthase, putative / 0.653
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
2nad NADFormate dehydrogenase / 0.652
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.652
1npd NADQuinate/shikimate dehydrogenase / 0.651
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.651
1wy7 SAHUncharacterized protein / 0.650
2rab FADGlutathione amide reductase / 0.650
3ad9 NADSubunit alpha of sarocosine oxidase / 0.650