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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cul FAD GidA-related protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cul FADGidA-related protein / 1.490
3ish FADThioredoxin reductase 1.8.1.9 0.806
3ict FADCoenzyme A disulfide reductase / 0.771
4gcm FADThioredoxin reductase 1.8.1.9 0.769
4jn9 FADDepH / 0.769
5j60 FADThioredoxin reductase / 0.759
2cvj FADThioredoxin reductase related protein / 0.757
3bg7 FADPyranose 2-oxidase / 0.755
3t37 FADPyridoxine 4-oxidase / 0.755
2ywl FADThioredoxin reductase related protein / 0.751
4u2l SFDCholesterol oxidase 1.1.3.6 0.751
4xxg FADCholesterol oxidase 1.1.3.6 0.749
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.747
1mxt FAECholesterol oxidase 1.1.3.6 0.746
1n4v FADCholesterol oxidase 1.1.3.6 0.745
1b4v FADCholesterol oxidase 1.1.3.6 0.744
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.744
1tde FADThioredoxin reductase 1.8.1.9 0.742
1f8s FADL-amino-acid oxidase 1.4.3.2 0.741
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.740
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.735
1cbo FADCholesterol oxidase 1.1.3.6 0.735
1zx9 FADMercuric reductase 1.16.1.1 0.734
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.734
4up3 FADThioredoxin reductase / 0.734
3atq FDAConserved Archaeal protein / 0.733
4gur FADLysine-specific histone demethylase 1B 1 0.733
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.732
1n4w FADCholesterol oxidase 1.1.3.6 0.730
2rgh FADAlpha-Glycerophosphate Oxidase / 0.729
3b6d FAECholesterol oxidase 1.1.3.6 0.729
4opd FDAConserved Archaeal protein / 0.729
3k4c FADPyranose 2-oxidase / 0.727
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.726
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.726
2yg3 FADPutrescine oxidase / 0.726
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.725
3f8d FADNADH oxidase/thioredoxin reductase / 0.723
4z26 FADPutative GMC-type oxidoreductase R135 1 0.723
2eq7 FADDihydrolipoyl dehydrogenase / 0.721
4c3y FAD3-ketosteroid dehydrogenase / 0.721
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.719
1tdf FADThioredoxin reductase 1.8.1.9 0.719
1trb FADThioredoxin reductase 1.8.1.9 0.719
1ijh FADCholesterol oxidase 1.1.3.6 0.718
3gyj FADCholesterol oxidase 1.1.3.6 0.718
3r9u FADThioredoxin reductase / 0.718
4em4 FADCoenzyme A disulfide reductase / 0.718
4ntc FADThioredoxin reductase gliT / 0.718
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.717
1cf3 FADGlucose oxidase 1.1.3.4 0.716
1n1p FADCholesterol oxidase 1.1.3.6 0.716
1cc2 FADCholesterol oxidase 1.1.3.6 0.714
1geu FADGlutathione reductase 1.8.1.7 0.713
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.712
2qa1 FADPgaE / 0.711
4rek FADCholesterol oxidase 1.1.3.6 0.709
4qi7 FADCellobiose dehydrogenase / 0.707
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.706
2q0l FADThioredoxin reductase 1.8.1.9 0.705
2yg4 FADPutrescine oxidase / 0.704
3icr FADCoenzyme A disulfide reductase / 0.703
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.702
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.702
4qi5 FADCellobiose dehydrogenase / 0.700
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.700
3cty FADProbable thioredoxin reductase / 0.699
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
3fpz AHZThiamine thiazole synthase / 0.698
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
1zk7 FADMercuric reductase 1.16.1.1 0.695
3lsi FADPyranose 2-oxidase / 0.694
4a5l FADThioredoxin reductase / 0.692
4ccq FADThioredoxin reductase / 0.692
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.691
4ynt FDAGlucose oxidase, putative / 0.691
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.688
2b9x FADPutative aminooxidase / 0.687
3f8p NADNADH oxidase/thioredoxin reductase / 0.686
3mj4 FADUDP-galactopyranose mutase / 0.686
3syi FADSulfide-quinone reductase / 0.686
3t2k FADSulfide-quinone reductase / 0.686
4usr FADMonooxygenase / 0.686
3cn8 FADPolyamine oxidase FMS1 / 0.685
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.685
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.684
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.684
4ap3 FADSteroid monooxygenase / 0.684
2xvi FADPutative flavin-containing monooxygenase / 0.683
3ad9 NADSubunit alpha of sarocosine oxidase / 0.682
3kve FADL-amino-acid oxidase / 0.682
4opt FDAConserved Archaeal protein / 0.680
4z24 FADPutative GMC-type oxidoreductase R135 1 0.680
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.679
2hqm FADGlutathione reductase 1.8.1.7 0.678
2ign FADPyranose 2-oxidase / 0.678
3pl8 FADPyranose 2-oxidase / 0.678
3qvr FADGlucose oxidase 1.1.3.4 0.678
4mok FADPyranose 2-oxidase / 0.677
1nhr FADNADH peroxidase 1.11.1.1 0.676
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
2npx FADNADH peroxidase 1.11.1.1 0.675
4at0 FADPossible succinate dehydrogenase / 0.675
4gdc FADUDP-galactopyranose mutase / 0.675
5buk FADFADH2-dependent halogenase / 0.675
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.674
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.674
2r0c FADPutative FAD-monooxygenase / 0.674
3fbs FADOxidoreductase / 0.674
4u2t FADCholesterol oxidase 1.1.3.6 0.674
1ger FADGlutathione reductase 1.8.1.7 0.673
1get FADGlutathione reductase 1.8.1.7 0.673
2b9w FADPutative aminooxidase / 0.673
2rgo FADAlpha-Glycerophosphate Oxidase / 0.673
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.672
3kpk FADSulfide-quinone reductase / 0.672
4jnq FDAThioredoxin reductase / 0.672
2eq7 NADDihydrolipoyl dehydrogenase / 0.671
3lsh FADPyranose 2-oxidase / 0.671
2eq8 FADDihydrolipoyl dehydrogenase / 0.669
2tpr FADTrypanothione reductase 1.8.1.12 0.669
3kkj FADRenalase / 0.669
4ntd FADThioredoxin reductase / 0.669
3sz0 FADSulfide-quinone reductase / 0.668
3t14 FADSulfide-quinone reductase / 0.668
4cbq FADThioredoxin reductase / 0.668
4fwf FADLysine-specific histone demethylase 1B 1 0.668
3f8r NAPNADH oxidase/thioredoxin reductase / 0.667
2xlr FADPutative flavin-containing monooxygenase / 0.666
2zbw FADFerredoxin--NADP reductase / 0.666
4qi4 FADCellobiose dehydrogenase / 0.666
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.665
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.664
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
4ccr FADThioredoxin reductase / 0.664
2jae FADL-amino acid oxidase / 0.663
3hdy FDAUDP-galactopyranose mutase / 0.663
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.663
3ada NADSubunit alpha of sarocosine oxidase / 0.662
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.661
3cgc FADCoenzyme A disulfide reductase / 0.661
3jsk AHZThiamine thiazole synthase / 0.661
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.661
2x8g FADThioredoxin glutathione reductase / 0.660
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.660
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.659
3cgd FADCoenzyme A disulfide reductase / 0.659
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 0.658
1pdh FASp-hydroxybenzoate hydroxylase / 0.657
3ics FADCoenzyme A disulfide reductase / 0.657
4nev FADTrypanothione reductase / 0.657
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
2q0k FADThioredoxin reductase 1.8.1.9 0.656
4j16 NAPNAD(P) transhydrogenase subunit beta / 0.656
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.656
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.656
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.655
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.655
5l3d FADLysine-specific histone demethylase 1A 1 0.655
3cge FADCoenzyme A disulfide reductase / 0.654
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.653
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.652
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.652
4b69 FADL-ornithine N(5)-monooxygenase / 0.651
3k4n FADPyranose 2-oxidase / 0.650
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.650