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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yt0 ADP Endoplasmin

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1yt0 ADPEndoplasmin / 0.859
4xcj ADPHeat shock cognate 90 kDa protein / 0.810
4xcl AGSHeat shock cognate 90 kDa protein / 0.782
3t1k ANPHeat shock protein HSP 90-alpha / 0.768
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.766
2ior ADPChaperone protein HtpG / 0.761
4gqt ADPHeat shock protein 90 / 0.759
4xc0 ACPHeat shock cognate 90 kDa protein / 0.759
2xk2 ADPHeat shock protein HSP 90-alpha / 0.755
3t10 ACPHeat shock protein HSP 90-alpha / 0.751
3t2s AGSHeat shock protein HSP 90-alpha / 0.750
2o1u ANPEndoplasmin / 0.743
2xcm ADPCytosolic heat shock protein 90 / 0.743
1amw ADPATP-dependent molecular chaperone HSP82 / 0.742
2yef ANPHeat shock protein HSP 90-alpha / 0.733
1byq ADPHeat shock protein HSP 90-alpha / 0.729
1y4s ADPChaperone protein HtpG / 0.727
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.716
4ipe ANPTNF receptor-associated protein 1 / 0.703
4wuc ANPDNA gyrase subunit B / 0.703
2o1v ADPEndoplasmin / 0.701
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.701
3t0z ATPHeat shock protein HSP 90-alpha / 0.701
2wep ADPATP-dependent molecular chaperone HSP82 / 0.699
3h4l ANPDNA mismatch repair protein PMS1 / 0.693
4gt8 ADPSensor protein VraS 2.7.13.3 0.692
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.687
4prv ADPDNA gyrase subunit B / 0.684
1qy5 NECEndoplasmin / 0.682
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.681
3ied AN2HSP90 / 0.678
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.677
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.676
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.674
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.673
2yeg XQGHeat shock protein HSP 90-alpha / 0.672
4ivg ANPTNF receptor-associated protein 1 / 0.672
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.665
3sl2 ATPSensor histidine kinase WalK / 0.664
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.662
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.660
4jql VJ6Heat shock protein HSP 90-alpha / 0.659
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.656
2hch N5AEndoplasmin / 0.656