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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o6y ACP Serine/threonine-protein kinase PknB 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 1.116
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.890
4xlv ACPInsulin receptor 2.7.10.1 0.805
4dee ADPAurora kinase A 2.7.11.1 0.804
2pui ADPMethylthioribose kinase 2.7.1.100 0.801
4gyi ADPUncharacterized protein / 0.800
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.791
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.783
1mq4 ADPAurora kinase A 2.7.11.1 0.778
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.774
3cly ACPFibroblast growth factor receptor 2 / 0.774
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.773
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.772
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.769
2pyw ADPMethylthioribose kinase 2.7.1.100 0.767
4utd ACPAurora kinase A 2.7.11.1 0.765
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.763
2pul ACPMethylthioribose kinase 2.7.1.100 0.759
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.759
2py3 ACPFibroblast growth factor receptor 2 / 0.755
2pz5 ACPFibroblast growth factor receptor 2 / 0.754
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.752
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.752
5dt3 ATPAurora kinase A 2.7.11.1 0.751
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.750
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.749
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.748
3ori AGSSerine/threonine protein kinase / 0.748
5drd ATPAurora kinase A 2.7.11.1 0.748
5eg3 ACPFibroblast growth factor receptor 2 / 0.748
1ol6 ATPAurora kinase A 2.7.11.1 0.747
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.746
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.745
4ceg ADPAurora kinase A 2.7.11.1 0.745
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.743
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.742
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.742
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.742
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.739
5dr2 ATPAurora kinase A 2.7.11.1 0.739
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.738
3bu5 ATPInsulin receptor 2.7.10.1 0.737
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.736
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.735
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.733
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.733
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.731
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.730
2pzp ACPFibroblast growth factor receptor 2 / 0.730
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.729
2pun ACPMethylthioribose kinase 2.7.1.100 0.729
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.729
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.729
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.729
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.728
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.728
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.728
5dos ATPAurora kinase A 2.7.11.1 0.728
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.726
2olc ADPMethylthioribose kinase 2.7.1.100 0.726
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.726
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.725
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.725
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.724
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.724
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.722
5dn3 ATPAurora kinase A 2.7.11.1 0.722
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.720
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.719
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.717
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.717
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.716
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.715
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.715
4ysj ADPCalmodulin-like domain protein kinase / 0.715
1cm8 ANPMitogen-activated protein kinase 12 / 0.714
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.713
3oro AGSSerine/threonine protein kinase / 0.713
4bn1 ADPAurora kinase A 2.7.11.1 0.713
4o1p ANPRibonuclease L / 0.713
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.712
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.711
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.710
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.710
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
4n57 ADPAPH(2'')-Id / 0.709
5ce3 ADPProtein kinase YopO / 0.709
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.708
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.708
4o4d ATPKinase / 0.707
3c4z ADPRhodopsin kinase / 0.706
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.706
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.706
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.704
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.702
3c50 ADPRhodopsin kinase / 0.702
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.701
3qc9 ADPRhodopsin kinase / 0.701
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.701
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.700
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.700
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.699
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.697
1m0w ANPGlutathione synthetase 6.3.2.3 0.697
2dwb ANPAurora kinase A 2.7.11.1 0.697
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.697
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.697
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.695
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.695
2wqe ADPAurora kinase A 2.7.11.1 0.694
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.694
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.691
3c4w ATPRhodopsin kinase / 0.691
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.691
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.691
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.691
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.690
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.689
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.689
3t8o ATPRhodopsin kinase / 0.689
2pup ADPMethylthioribose kinase 2.7.1.100 0.688
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.688
5iqa GNPBifunctional AAC/APH 2.3.1 0.688
2vqd AP2Biotin carboxylase 6.3.4.14 0.687
4o4e ATPKinase / 0.687
4o4f ATPKinase / 0.687
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.685
4ork GDPBifunctional AAC/APH 2.3.1 0.685
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
5dnr ATPAurora kinase A 2.7.11.1 0.683
3hyo ADPPyridoxal kinase / 0.682
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.682
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.681
4ffm ADPUncharacterized protein / 0.681
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.680
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.680
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.679
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.679
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.679
5l8j ADPAurora kinase A 2.7.11.1 0.679
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.678
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.678
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
4qny ANPMitogen activated protein kinase, putative / 0.678
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.677
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.677
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.677
2pwl ACPFibroblast growth factor receptor 2 / 0.675
5iqi GNPBifunctional AAC/APH 2.3.1 0.675
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.674
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.674
2j9g ADPBiotin carboxylase 6.3.4.14 0.673
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.673
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.672
2pml ANPUncharacterized protein / 0.671
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.670
3ibq ATPPyridoxal kinase / 0.670
2zdg ADPD-alanine--D-alanine ligase / 0.669
3c4x ATPRhodopsin kinase / 0.669
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.668
5byl GCPBifunctional AAC/APH 2.3.1 0.668
1ol5 ADPAurora kinase A 2.7.11.1 0.667
5dt4 ATPAurora kinase A 2.7.11.1 0.667
3q5i ANPProtein kinase, putative / 0.666
4c3r ACPAurora kinase A 2.7.11.1 0.666
1khb GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.665
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.665
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.664
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.664
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.664
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.664
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.664
3orp AGSSerine/threonine protein kinase / 0.663
5iqd GNPBifunctional AAC/APH 2.3.1 0.663
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.662
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.662
3wo0 ADPAlanine--anticapsin ligase / 0.662
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.662
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.661
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.661
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.661
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.661
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.661
5iqe GNPBifunctional AAC/APH 2.3.1 0.661
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.660
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.660
1foa UD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 2.4.1.101 0.659
4iwx ADPRibosomal protein S6--L-glutamate ligase / 0.659
5iqb GNPBifunctional AAC/APH 2.3.1 0.659
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.658
3ufx GDPSuccinate--CoA ligase [GDP-forming] subunit beta / 0.658
2yaa ATPDeath-associated protein kinase 2 / 0.657
3g8c ADPBiotin carboxylase 6.3.4.14 0.657
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.657
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.656
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.656
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.656
2x0q ATPAlcaligin biosynthesis protein / 0.656
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.656
4p5a FADFlavin-dependent thymidylate synthase / 0.656
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.655
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.655
3orm AGSSerine/threonine protein kinase / 0.654
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.654
1rfu ADPPyridoxal kinase 2.7.1.35 0.653
1u54 ACPActivated CDC42 kinase 1 / 0.653
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.653
3ort AGSSerine/threonine protein kinase / 0.653
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.653
3rv4 ADPBiotin carboxylase 6.3.4.14 0.652
5iqh GNPBifunctional AAC/APH 2.3.1 0.652
4o0w ADNAurora kinase A 2.7.11.1 0.650