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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nzx NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.847
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.796
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.785
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.782
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.781
4pxl NADAldehyde dehydrogenase3 / 0.780
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.779
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.778
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.777
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.772
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.771
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.768
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.765
4pt0 NADAldehyde dehydrogenase / 0.765
4i3w NADAldehyde dehydrogenase (NAD+) / 0.764
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.763
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.761
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.758
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.758
4pz2 NADAldehyde dehydrogenase 2-6 / 0.757
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.757
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.756
4i3v NADAldehyde dehydrogenase (NAD+) / 0.756
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.756
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.755
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.754
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.754
4i8p NADAminoaldehyde dehydrogenase 1 / 0.752
4i9b NADPutative betaine aldehyde dehyrogenase / 0.746
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.739
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
4i8q NADPutative betaine aldehyde dehyrogenase / 0.739
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.733
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.729
3iwj NADAminoaldehyde dehydrogenase / 0.725
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.723
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.719
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.718
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.715
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.714
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.714
4nmj NAPAldehyde dehydrogenase / 0.709
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.709
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.705
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.704
3b4w NADAldehyde dehydrogenase family protein / 0.703
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.703
1bi9 NADRetinal dehydrogenase 2 / 0.702
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.702
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.698
4h73 NDPAldehyde dehydrogenase / 0.695
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.683
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.678
2jg7 NADAntiquitin / 0.676
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.672
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.672
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.670
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.662
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.660
4f3x NADPutative aldehyde dehydrogenase / 0.657
3kt3 TYMTryptophan--tRNA ligase, cytoplasmic 6.1.1.2 0.656
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.655
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.651
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.651
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.650