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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lde NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.372
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.297
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.296
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.281
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.281
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.276
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.248
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.240
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.229
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.224
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.224
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.220
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.215
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.209
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.207
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.202
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.184
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.163
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.160
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.122
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.118
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.103
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.048
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.960
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.954
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.953
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.950
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.935
3wle NAD(R)-specific carbonyl reductase / 0.907
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.901
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.882
1yqd NAPSinapyl alcohol dehydrogenase / 0.878
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.870
3two NDPMannitol dehydrogenase / 0.864
4oaq NDPR-specific carbonyl reductase / 0.863
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.861
2dph NADFormaldehyde dismutase / 0.859
4c4o NADSADH / 0.851
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.849
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.832
1yqx NAPSinapyl alcohol dehydrogenase / 0.827
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.823
1u7h NADPutative ornithine cyclodeaminase / 0.820
4cpd NADAlcohol dehydrogenase / 0.816
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.813
1uxj NADMalate dehydrogenase / 0.810
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.803
1x7d NADPutative ornithine cyclodeaminase / 0.800
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.800
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.800
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.793
1uxk NADMalate dehydrogenase / 0.789
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.787
3jv7 NADSecondary alcohol dehydrogenase / 0.786
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.785
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.784
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.780
1f8f NADBenzyl alcohol dehydrogenase / 0.778
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.771
4jk3 NADUncharacterized protein / 0.771
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.770
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.770
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.766
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.764
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.763
4j43 NADUncharacterized protein / 0.763
1gv0 NADMalate dehydrogenase / 0.757
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.756
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.751
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.747
2voj NADAlanine dehydrogenase 1.4.1.1 0.745
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.744
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.743
4rqu NADAlcohol dehydrogenase class-P / 0.740
1ie3 NADMalate dehydrogenase / 0.739
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.739
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.737
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.730
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.730
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.728
2vwh NAPGlucose 1-dehydrogenase / 0.728
4j49 NADUncharacterized protein / 0.726
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.725
2vhx NADAlanine dehydrogenase 1.4.1.1 0.725
3wsw NADL-lactate dehydrogenase / 0.725
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.724
2d8a NADL-threonine 3-dehydrogenase / 0.723
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.722
2o4c NADErythronate-4-phosphate dehydrogenase / 0.721
4jji NADAlcohol dehydrogenase class-3 / 0.720
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.717
1ur5 NADMalate dehydrogenase / 0.716
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.715
1pjc NADAlanine dehydrogenase / 0.713
1pzh NADLactate dehydrogenase / 0.712
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.712
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.708
2cda NAPGlucose 1-dehydrogenase / 0.708
2x0i NAIMalate dehydrogenase / 0.707
3uko NADAlcohol dehydrogenase class-3 / 0.707
4i1i NADMalate dehydrogenase / 0.706
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.704
2x0r NADMalate dehydrogenase / 0.702
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.702
1b8v NADMalate dehydrogenase / 0.701
4l0q NADAlcohol dehydrogenase class-3 / 0.701
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.698
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.698
5a1t NAIL-lactate dehydrogenase / 0.697
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.696
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.696
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.695
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.695
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.694
1wze NADMalate dehydrogenase / 0.694
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.694
3kb6 NADD-lactate dehydrogenase / 0.691
1ib6 NADMalate dehydrogenase / 0.690
2aa3 AP0L-lactate dehydrogenase / 0.690
3ikt NADRedox-sensing transcriptional repressor Rex / 0.690
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.689
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.687
4b7x NAPProbable oxidoreductase / 0.687
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.687
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.687
3d64 NADAdenosylhomocysteinase / 0.685
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.684
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.684
4xq9 NADHomospermidine synthase 2.5.1.44 0.684
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.684
3ec7 NADInositol 2-dehydrogenase / 0.683
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.683
4plp NADHomospermidine synthase 2.5.1.44 0.682
4j4b NAIUncharacterized protein / 0.681
1sow NADL-lactate dehydrogenase 1.1.1.27 0.680
4j49 NAIUncharacterized protein / 0.680
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.679
2xaa NADSecondary alcohol dehydrogenase / 0.678
4k28 NADShikimate dehydrogenase family protein / 0.678
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.677
2vwq NAPGlucose 1-dehydrogenase / 0.677
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.677
1guy NADMalate dehydrogenase / 0.676
1pzg A3DLactate dehydrogenase / 0.676
2b5v NAPGlucose 1-dehydrogenase / 0.676
2hu2 NADC-terminal binding protein 1 / 0.675
2v7g NADUrocanate hydratase 4.2.1.49 0.674
4xqc NADHomospermidine synthase 2.5.1.44 0.673
5a05 NDPGlucose-fructose oxidoreductase / 0.673
1llu NADAlcohol dehydrogenase / 0.672
2fkn NADUrocanate hydratase 4.2.1.49 0.672
4tvb NADHomospermidine synthase 2.5.1.44 0.671
1bmd NADMalate dehydrogenase / 0.669
1c1d NAIPhenylalanine dehydrogenase / 0.669
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.669
3adp NAILambda-crystallin 1.1.1.45 0.669
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.669
4xrg NADHomospermidine synthase 2.5.1.44 0.667
1b8u NADMalate dehydrogenase / 0.666
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.666
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.666
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.666
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.666
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.665
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.664
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.664
2gsd NADFormate dehydrogenase / 0.664
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.663
4gl4 NAIAlcohol dehydrogenase class-3 / 0.663
2dfv NADL-threonine 3-dehydrogenase / 0.661
2y05 NAPProstaglandin reductase 1 / 0.661
4y1b NAPAntE / 0.661
3wfj NAD2-dehydropantoate 2-reductase / 0.660
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.659
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.659
1xcb NADRedox-sensing transcriptional repressor Rex / 0.659
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.659
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
2ph5 NADHomospermidine synthase / 0.657
4y0k NAPAntE / 0.657
2nad NADFormate dehydrogenase / 0.656
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.656
3oet NADErythronate-4-phosphate dehydrogenase / 0.655
3x2f NAIAdenosylhomocysteinase / 0.655
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.655
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.654
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.653
2ejv NADL-threonine 3-dehydrogenase / 0.653
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.653
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.653
4clo NAPPteridine reductase / 0.653
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.652
1qor NDPQuinone oxidoreductase 1 / 0.652
2dc1 NADProbable L-aspartate dehydrogenase / 0.652
4ros APRMalate dehydrogenase / 0.652
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.651
2rgj FADFlavin-containing monooxygenase / 0.650
3tqh NDPQuinone oxidoreductase / 0.650
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.650