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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1eny NAD Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.078
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.984
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.978
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.954
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.951
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.936
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.933
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.921
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.913
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.913
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.911
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.900
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.899
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.878
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.876
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.874
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.858
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.856
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.855
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.847
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.835
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.833
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.832
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.824
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.802
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.800
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.800
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.796
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.782
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.778
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.778
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.776
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.765
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.761
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.760
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.760
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.758
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.756
4b79 NADProbable short-chain dehydrogenase / 0.756
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.751
3ak4 NADNADH-dependent quinuclidinone reductase / 0.750
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.750
1v35 NAIEnoyl-ACP reductase / 0.749
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.748
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.748
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.745
3wds NADNADH-dependent quinuclidinone reductase / 0.743
1vrw NAIEnoyl-ACP reductase / 0.740
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.740
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.740
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.738
4fn4 NADShort chain dehydrogenase / 0.738
2yut NAPPutative short-chain oxidoreductase / 0.736
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.735
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.735
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.733
3r3s NADPutative oxidoreductase / 0.731
2wsb NADGalactitol dehydrogenase / 0.729
3ai3 NDPNADPH-sorbose reductase / 0.729
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.729
4qec NAPElxO / 0.729
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.728
3sju NDPKeto reductase / 0.728
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.727
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.727
2jah NDPClavaldehyde dehydrogenase / 0.726
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.726
1x7h NDPPutative ketoacyl reductase 1.3.1 0.724
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.724
3p19 NDPPutative blue fluorescent protein / 0.722
4kwh NAPReductase homolog / 0.721
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.720
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.719
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.718
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.717
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.717
3sx2 NADUncharacterized protein / 0.716
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.715
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.715
4qed NAPElxO / 0.715
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.714
4o1m NADEnoyl-acyl carrier reductase / 0.714
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.712
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.712
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.711
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.710
4bmv NAPShort-chain dehydrogenase / 0.710
4hxy NDPPlm1 / 0.709
3ai2 NDPNADPH-sorbose reductase / 0.708
2c29 NAPDihydroflavonol 4-reductase / 0.707
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.707
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.706
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.706
3s55 NADPutative short-chain dehydrogenase/reductase / 0.706
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.705
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.705
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.702
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.702
1enp NADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic 1.3.1.9 0.701
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.701
1x7g NAPPutative ketoacyl reductase 1.3.1 0.700
1oaa NAPSepiapterin reductase 1.1.1.153 0.697
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.697
4wec NADShort chain dehydrogenase / 0.696
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.695
5jyd NADShort chain dehydrogenase / 0.695
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.693
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.693
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.693
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.691
1sby NADAlcohol dehydrogenase 1.1.1.1 0.690
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.689
3o26 NDPSalutaridine reductase / 0.689
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.688
2dte NAIGlucose 1-dehydrogenase related protein / 0.688
3geg NADShort-chain dehydrogenase/reductase SDR / 0.688
3uce NDPDehydrogenase / 0.688
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.686
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.685
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.685
3tn7 NJPShort-chain alcohol dehydrogenase / 0.684
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.684
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.683
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.683
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.683
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.683
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.681
1pr9 NAPL-xylulose reductase 1.1.1.10 0.679
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.679
4hwk NAPSepiapterin reductase 1.1.1.153 0.679
5d2e NAPMlnE / 0.679
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.678
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.678
2p5y NADUDP-glucose 4-epimerase / 0.677
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.677
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.676
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.676
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.676
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.673
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.673
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.673
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.672
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.672
2yy7 NADL-threonine dehydrogenase / 0.672
3l77 NJPShort-chain alcohol dehydrogenase / 0.672
1sny NAPLD36273p / 0.671
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.671
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.671
3d3w NAPL-xylulose reductase 1.1.1.10 0.671
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.670
1zid ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.669
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.669
4yag NAIC alpha-dehydrogenase / 0.669
4yai NAIC alpha-dehydrogenase / 0.669
5jla NADPutative short-chain dehydrogenase/reductase / 0.668
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.667
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.667
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.667
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.667
4u7w NDPMxaA / 0.667
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.666
3a9w NADNDP-sugar epimerase / 0.665
3orf NADDihydropteridine reductase 1.5.1.34 0.664
1ek5 NADUDP-glucose 4-epimerase / 0.663
2bd0 NAPSepiapterin reductase / 0.663
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.663
3icp NADNAD-dependent epimerase/dehydratase / 0.661
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.661
3aw9 NADNAD-dependent epimerase/dehydratase / 0.660
3mje NDPAmphB / 0.660
4j7u NAPSepiapterin reductase 1.1.1.153 0.660
1zem NADXylitol dehydrogenase / 0.659
1ae1 NAPTropinone reductase 1 / 0.658
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.658
3tsc NADUncharacterized protein / 0.658
2wdz NADGalactitol dehydrogenase / 0.657
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.656
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.656
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.656
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.656
4j7x NAPSepiapterin reductase 1.1.1.153 0.656
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.655
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.655
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.655
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.654
5lc1 NADL-threonine 3-dehydrogenase / 0.654
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.653
2c20 NADUDP-glucose 4-epimerase / 0.653
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.653
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.652
1xkq NDPUncharacterized protein / 0.652
4n5n NAPAcetoacetyl-CoA reductase 1.1.1.36 0.652
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.651
4dbz NDPPutative ketoacyl reductase 1.3.1 0.651