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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ux9ANPMitogen-activated protein kinase 82.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ux9ANPMitogen-activated protein kinase 82.7.11.241.000
2p33J07Mitogen-activated protein kinase 102.7.11.240.562
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.539
1pmn984Mitogen-activated protein kinase 102.7.11.240.530
3cgfJNFMitogen-activated protein kinase 102.7.11.240.528
3ttiKBIMitogen-activated protein kinase 102.7.11.240.528
2xrwANPMitogen-activated protein kinase 82.7.11.240.520
3kvxFMYMitogen-activated protein kinase 102.7.11.240.517
3i60E86Mitogen-activated protein kinase 12.7.11.240.513
3be9P04Casein kinase II subunit alpha2.7.11.10.511
1om1IQACasein kinase II subunit alpha2.7.11.10.504
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.502
3ttjJBIMitogen-activated protein kinase 102.7.11.240.502
4dgnLU2Casein kinase II subunit alpha2.7.11.10.499
1jnkANPMitogen-activated protein kinase 102.7.11.240.498
3cgoJNOMitogen-activated protein kinase 102.7.11.240.495
3eljGS7Mitogen-activated protein kinase 82.7.11.240.492
4anmWULCasein kinase II subunit alpha2.7.11.10.491
3mtfA3FActivin receptor type-12.7.11.300.490
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.490
4btjATPTau-tubulin kinase 12.7.11.10.490
4jboWPHAurora kinase A2.7.11.10.489
4g1wG1WMitogen-activated protein kinase 82.7.11.240.488
4btjADPTau-tubulin kinase 12.7.11.10.487
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.487
1pmv537Mitogen-activated protein kinase 102.7.11.240.486
2excJNKMitogen-activated protein kinase 102.7.11.240.485
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.485
3hmm855TGF-beta receptor type-12.7.11.300.484
4dymIYZActivin receptor type-12.7.11.300.480
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.480
2zdt46CMitogen-activated protein kinase 102.7.11.240.479
4lfiGNPCasein kinase II subunit alpha2.7.11.10.475
4bgg844Activin receptor type-12.7.11.300.474
1dawANPCasein kinase II subunit alpha2.7.11.10.473
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.473
2pvhP19Casein kinase II subunit alpha2.7.11.10.472
1m2pHNACasein kinase II subunit alpha2.7.11.10.471
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.471
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
3gxlQIGTGF-beta receptor type-12.7.11.300.470
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.470
2xs0ANPMitogen-activated protein kinase 82.7.11.240.469
4grb0XGCasein kinase II subunit alpha2.7.11.10.469
2b1pAIZMitogen-activated protein kinase 102.7.11.240.468
2pvnP63Casein kinase II subunit alpha2.7.11.10.467
4fv9E71Mitogen-activated protein kinase 12.7.11.240.467
4jbpYPHAurora kinase A2.7.11.10.467
1aq1STUCyclin-dependent kinase 22.7.11.220.466
3at4CCKCasein kinase II subunit alpha2.7.11.10.466
4aqc88ATyrosine-protein kinase JAK2/0.466
4fv6E57Mitogen-activated protein kinase 12.7.11.240.466
5e8ySTUTGF-beta receptor type-22.7.11.300.466
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.464
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.463
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.463
4hge15VTyrosine-protein kinase JAK2/0.463
4qnyANPMitogen activated protein kinase, putative/0.463
4wsqKSAAP2-associated protein kinase 12.7.11.10.463
1dayGNPCasein kinase II subunit alpha2.7.11.10.462
2ijmATPFocal adhesion kinase 12.7.10.20.462
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.460
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
4deeADPAurora kinase A2.7.11.10.460
1i44ACPInsulin receptor2.7.10.10.459
2pvlP55Casein kinase II subunit alpha2.7.11.10.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.458
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.458
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.457
2pvmP29Casein kinase II subunit alpha2.7.11.10.456
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.456
4dgmAGICasein kinase II subunit alpha2.7.11.10.456
4k33ACPFibroblast growth factor receptor 32.7.10.10.456
1fvv107Cyclin-dependent kinase 22.7.11.220.455
2w05FRTCyclin-dependent kinase 22.7.11.220.454
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.454
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.454
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.453
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.453
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.453
3rak03ZCyclin-dependent kinase 22.7.11.220.453
4c58824Cyclin-G-associated kinase2.7.11.10.453
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.452
2o2u738Mitogen-activated protein kinase 102.7.11.240.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.450
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.450
4j95ACPFibroblast growth factor receptor 2/0.450
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.449
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.449
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.449
4o0uADNAurora kinase A2.7.11.10.449
1g5sI17Cyclin-dependent kinase 22.7.11.220.448
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.448
4btmF8ETau-tubulin kinase 12.7.11.10.448
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.448
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
5dnrATPAurora kinase A2.7.11.10.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.446
3dfcANPDeath-associated protein kinase 12.7.11.10.446
4hvi19STyrosine-protein kinase JAK32.7.10.20.446
3qu0X40Cyclin-dependent kinase 22.7.11.220.445
4c4f7CEDual specificity protein kinase TTK2.7.12.10.445
4jqeANPCasein kinase II subunit alpha2.7.11.10.444
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.443
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.443
3pe2E1BCasein kinase II subunit alpha2.7.11.10.443
3pxkPXKFocal adhesion kinase 12.7.10.20.443
3q9xEMOCasein kinase II subunit alpha2.7.11.10.443
3uyt0CKCasein kinase I isoform delta2.7.11.10.443
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.443
4e730NRMitogen-activated protein kinase 82.7.11.240.443
2btsU32Cyclin-dependent kinase 22.7.11.220.442
2vttLZDCyclin-dependent kinase 22.7.11.220.442
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.442
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.441
2zdu446Mitogen-activated protein kinase 102.7.11.240.441
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
5awmANPStress-activated protein kinase JNK2.7.11.240.441
5dosATPAurora kinase A2.7.11.10.441
2h96893Mitogen-activated protein kinase 82.7.11.240.440
2j0lANPFocal adhesion kinase 12.7.10.20.440
3gubGUBDeath-associated protein kinase 12.7.11.10.440
3nynSGVG protein-coupled receptor kinase 62.7.11.160.440