scPDB - Distribution of Cavity Similarity values of 4bux entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4bux	F35	Tankyrase-2	2.4.2.30

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4bux	F35	Tankyrase-2	2.4.2.30	1.000
4l0t	1V0	Tankyrase-2	2.4.2.30	0.810
4bue	JQF	Tankyrase-2	2.4.2.30	0.801
4bus	32F	Tankyrase-2	2.4.2.30	0.780
4l34	1VG	Tankyrase-2	2.4.2.30	0.776
4l2g	1V4	Tankyrase-2	2.4.2.30	0.729
4bs4	A64	Tankyrase-2	2.4.2.30	0.724
4buw	F33	Tankyrase-2	2.4.2.30	0.710
4hlh	20D	Tankyrase-2	2.4.2.30	0.684
4iue	AJ4	Tankyrase-2	2.4.2.30	0.670
4hlf	15Z	Tankyrase-2	2.4.2.30	0.650
4kzl	20D	Tankyrase-2	2.4.2.30	0.647
4l0i	1UW	Tankyrase-2	2.4.2.30	0.642
4hl5	15W	Tankyrase-2	2.4.2.30	0.640
4l2k	1V8	Tankyrase-2	2.4.2.30	0.639
4l33	F70	Tankyrase-2	2.4.2.30	0.636
4buf	F36	Tankyrase-2	2.4.2.30	0.635
4l0s	1UZ	Tankyrase-2	2.4.2.30	0.635
4j22	AJ7	Tankyrase-2	2.4.2.30	0.634
4l0v	1V1	Tankyrase-2	2.4.2.30	0.633
4hlm	16S	Tankyrase-2	2.4.2.30	0.631
4bj9	UHB	Tankyrase-2	2.4.2.30	0.630
4l2f	1V3	Tankyrase-2	2.4.2.30	0.627
4l32	1VF	Tankyrase-2	2.4.2.30	0.619
4avw	G18	Tankyrase-2	2.4.2.30	0.614
4hkk	AGI	Tankyrase-2	2.4.2.30	0.613
5aku	29F	Tankyrase-2	2.4.2.30	0.610
3p0p	NNF	Tankyrase-2	2.4.2.30	0.608
4buu	F38	Tankyrase-2	2.4.2.30	0.608
4bud	29F	Tankyrase-2	2.4.2.30	0.606
4j21	AJ6	Tankyrase-2	2.4.2.30	0.600
4but	31F	Tankyrase-2	2.4.2.30	0.594
4hlk	431	Tankyrase-2	2.4.2.30	0.592
4hkn	LU2	Tankyrase-2	2.4.2.30	0.585
4tkg	09L	Tankyrase-2	2.4.2.30	0.576
4hmh	F94	Tankyrase-2	2.4.2.30	0.572
4pnr	G18	Tankyrase-2	2.4.2.30	0.569
4hki	FLN	Tankyrase-2	2.4.2.30	0.560
4pnm	NU1	Tankyrase-2	2.4.2.30	0.525
4msk	2C8	Tankyrase-1	2.4.2.30	0.524
4bjb	P34	Tankyrase-2	2.4.2.30	0.508
4l09	1UR	Tankyrase-2	2.4.2.30	0.505
4hyf	1AK	Tankyrase-2	2.4.2.30	0.502
4buv	16I	Tankyrase-2	2.4.2.30	0.499
4tjy	3GN	Tankyrase-2	2.4.2.30	0.490
4k4e	K4E	Tankyrase-1	2.4.2.30	0.481
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.475
3tqc	ADP	Pantothenate kinase	/	0.475
3l9m	L9M	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.473
1y2b	DEE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.468
4b13	X25	Glycylpeptide N-tetradecanoyltransferase	/	0.467
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.463
4l6s	1WQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.462
4avu	LDR	Tankyrase-2	2.4.2.30	0.457
4j3l	AJ5	Tankyrase-2	2.4.2.30	0.457
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.456
5cb3	APR	O-acetyl-ADP-ribose deacetylase	/	0.454
1knr	FAD	L-aspartate oxidase	1.4.3.16	0.452
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.452
1ndh	FAD	NADH-cytochrome b5 reductase 3	1.6.2.2	0.451
3l3m	A92	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.451
5egh	PC	Ectonucleotide pyrophosphatase/phosphodiesterase family member 6	/	0.451
3dop	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.449
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.448
1fdu	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.448
3x2f	NAI	Adenosylhomocysteinase	/	0.448
4b1j	A1R	Poly(ADP-ribose) glycohydrolase	3.2.1.143	0.447
4i9i	1DY	Tankyrase-1	2.4.2.30	0.447
2dsh	SAH	Diphthine synthase	/	0.446
3mau	PLR	Putative sphingosine-1-phosphate lyase	/	0.446
4gv7	MEW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.446
2gjn	FMN	Nitronate monooxygenase	1.13.12.16	0.445
2whq	HI6	Acetylcholinesterase	3.1.1.7	0.445
3k5f	AYH	Beta-secretase 1	3.4.23.46	0.445
2bf7	HBI	Pteridine reductase 1	1.5.1.33	0.444
3da2	4MD	Carbonic anhydrase 13	4.2.1.1	0.444
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
3rsv	3RS	Beta-secretase 1	3.4.23.46	0.443
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.443
4bv9	NDP	Ketimine reductase mu-crystallin	1.5.1.25	0.443
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
3gn7	3GN	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.442
2qim	ZEA	Class 10 plant pathogenesis-related protein	/	0.441
3g1r	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.441
3qpo	PFR	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.441
3tp0	FO5	HTH-type transcriptional regulator EthR	/	0.441
5cb5	APR	O-acetyl-ADP-ribose deacetylase	/	0.441
2rhr	EMO	Putative ketoacyl reductase	1.3.1	0.440