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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.11.000
3lltANPProtein serine/threonine kinase-1/0.541
2yaaATPDeath-associated protein kinase 2/0.529
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.529
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.524
4l9i8PRRhodopsin kinase/0.501
2ijmADPFocal adhesion kinase 12.7.10.20.498
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.496
5av2KMPDeath-associated protein kinase 12.7.11.10.494
3bqr4RBDeath-associated protein kinase 3/0.493
3dfcANPDeath-associated protein kinase 12.7.11.10.493
4jboWPHAurora kinase A2.7.11.10.492
4grb0XGCasein kinase II subunit alpha2.7.11.10.489
3i60E86Mitogen-activated protein kinase 12.7.11.240.484
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.482
4bcmT7ZCyclin-dependent kinase 22.7.11.220.482
3c4xATPRhodopsin kinase/0.481
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.481
4jia1K3Tyrosine-protein kinase JAK2/0.479
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.478
5av3KMPDeath-associated protein kinase 12.7.11.10.477
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
5dosATPAurora kinase A2.7.11.10.475
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.471
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.470
3nynSGVG protein-coupled receptor kinase 62.7.11.160.470
2j0lANPFocal adhesion kinase 12.7.10.20.469
4fv6E57Mitogen-activated protein kinase 12.7.11.240.469
4j95ACPFibroblast growth factor receptor 2/0.469
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.467
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.466
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.466
4anmWULCasein kinase II subunit alpha2.7.11.10.466
4qmlANPSerine/threonine-protein kinase 242.7.11.10.465
1jklANPDeath-associated protein kinase 12.7.11.10.464
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.464
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.464
3be9P04Casein kinase II subunit alpha2.7.11.10.464
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
4j99ACPFibroblast growth factor receptor 2/0.463
2pvmP29Casein kinase II subunit alpha2.7.11.10.461
4ysjADPCalmodulin-like domain protein kinase/0.461
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.460
4dgmAGICasein kinase II subunit alpha2.7.11.10.460
4c3pACPAurora kinase A2.7.11.10.459
4jbpYPHAurora kinase A2.7.11.10.458
2x9fX9FEphrin type-B receptor 42.7.10.10.456
3q9xEMOCasein kinase II subunit alpha2.7.11.10.456
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.455
3gu7ADPDeath-associated protein kinase 12.7.11.10.455
3kvxFMYMitogen-activated protein kinase 102.7.11.240.455
2pvlP55Casein kinase II subunit alpha2.7.11.10.454
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.454
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.454
4o0wADNAurora kinase A2.7.11.10.454
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.452
4qnyANPMitogen activated protein kinase, putative/0.452
3u4uLNHCasein kinase II subunit alpha2.7.11.10.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.451
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.450
3begANPSRSF protein kinase 12.7.11.10.449
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.448
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.447
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.446
3t8oATPRhodopsin kinase/0.446
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.444
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.443
3bu5ATPInsulin receptor2.7.10.10.443
3ztxZTXAurora kinase B-A2.7.11.10.443
4dgnLU2Casein kinase II subunit alpha2.7.11.10.443
3c4zADPRhodopsin kinase/0.442
3my5RFZCyclin-dependent kinase 22.7.11.220.442
5cvfATPCasein kinase II subunit alpha2.7.11.10.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.441
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.440
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.440
4s33ANPMitogen-activated protein kinase 12.7.11.240.440