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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3a7jADPSerine/threonine-protein kinase 242.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3a7jADPSerine/threonine-protein kinase 242.7.11.11.000
4qmzB49Serine/threonine-protein kinase 242.7.11.10.534
3a7hATPSerine/threonine-protein kinase 242.7.11.10.533
2xikJ60Serine/threonine-protein kinase 252.7.11.10.531
4qmlANPSerine/threonine-protein kinase 242.7.11.10.520
3t8oATPRhodopsin kinase/0.514
3c50ADPRhodopsin kinase/0.513
3c4wATPRhodopsin kinase/0.510
4qmpDKISerine/threonine-protein kinase 242.7.11.10.510
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.506
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.502
4qms1N1Serine/threonine-protein kinase 242.7.11.10.501
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.491
4qmySTUSerine/threonine-protein kinase 242.7.11.10.487
2c6tDT5Cyclin-dependent kinase 22.7.11.220.484
2bhhRYUCyclin-dependent kinase 22.7.11.220.481
2x1nX1NCyclin-dependent kinase 22.7.11.220.478
4lopSB4Mitogen-activated protein kinase 14/0.476
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.475
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2qo9ANPEphrin type-A receptor 32.7.10.10.470
2wpa889Cyclin-dependent kinase 22.7.11.220.469
2wxvWXVCyclin-dependent kinase 22.7.11.220.467
4eomATPCyclin-dependent kinase 22.7.11.220.467
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.467
2uzdC85Cyclin-dependent kinase 22.7.11.220.466
2ijmATPFocal adhesion kinase 12.7.10.20.465
2uzlC94Cyclin-dependent kinase 22.7.11.220.465
3c4xATPRhodopsin kinase/0.465
4fkv61KCyclin-dependent kinase 22.7.11.220.463
4jqeANPCasein kinase II subunit alpha2.7.11.10.463
1gih1PUCyclin-dependent kinase 22.7.11.220.462
3rni21ZCyclin-dependent kinase 22.7.11.220.462
2iw84SPCyclin-dependent kinase 22.7.11.220.461
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
1h1r6CPCyclin-dependent kinase 22.7.11.220.460
4loqSB4Mitogen-activated protein kinase 14/0.460
2acxANPG protein-coupled receptor kinase 62.7.11.160.459
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.459
3bu5ATPInsulin receptor2.7.10.10.458
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.457
3ddpRC8Cyclin-dependent kinase 22.7.11.220.457
3qu0X40Cyclin-dependent kinase 22.7.11.220.457
5auwQUEDeath-associated protein kinase 12.7.11.10.457
5drdATPAurora kinase A2.7.11.10.457
3bhtMFRCyclin-dependent kinase 22.7.11.220.456
4bcpT3CCyclin-dependent kinase 22.7.11.220.456
1oitHDTCyclin-dependent kinase 22.7.11.220.455
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
3gxlQIGTGF-beta receptor type-12.7.11.300.455
3s2pPMUCyclin-dependent kinase 22.7.11.220.455
3zep1NXTyrosine-protein kinase JAK32.7.10.20.455
1oguST8Cyclin-dependent kinase 22.7.11.220.454
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.454
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.454
3ormAGSSerine/threonine protein kinase/0.453
3r73X87Cyclin-dependent kinase 22.7.11.220.453
4eooATPCyclin-dependent kinase 22.7.11.220.453
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.453
2hog710Serine/threonine-protein kinase Chk12.7.11.10.452
3ddqRRCCyclin-dependent kinase 22.7.11.220.452
5dt3ATPAurora kinase A2.7.11.10.452
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.451
1ir3ANPInsulin receptor2.7.10.10.450
1vyw292Cyclin-dependent kinase 22.7.11.220.450
2wihP48Cyclin-dependent kinase 22.7.11.220.450
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.450
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.450
4fkg4CKCyclin-dependent kinase 22.7.11.220.450
4iwd1JCHepatocyte growth factor receptor2.7.10.10.450
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
1oi9N20Cyclin-dependent kinase 22.7.11.220.449
3lfqA28Cyclin-dependent kinase 22.7.11.220.449
3qc9ADPRhodopsin kinase/0.449
3rm719ZCyclin-dependent kinase 22.7.11.220.449
2wotZZGTGF-beta receptor type-12.7.11.300.448
1csnATPCasein kinase I homolog 12.7.11.10.447
4e4m0NHTyrosine-protein kinase JAK2/0.447
4fx360KCyclin-dependent kinase 22.7.11.220.447
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4ek610KCyclin-dependent kinase 22.7.11.220.446
4fkr45KCyclin-dependent kinase 22.7.11.220.446
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.445
2iw94SPCyclin-dependent kinase 22.7.11.220.445
3gubGUBDeath-associated protein kinase 12.7.11.10.445
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.444
3gu5ANPDeath-associated protein kinase 12.7.11.10.444
4k33ACPFibroblast growth factor receptor 32.7.10.10.444
4zseANPEpidermal growth factor receptor2.7.10.10.444
1p2a5BNCyclin-dependent kinase 22.7.11.220.443
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.443
2b7aIZATyrosine-protein kinase JAK2/0.442
2btrU73Cyclin-dependent kinase 22.7.11.220.442
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.442
4fkw62KCyclin-dependent kinase 22.7.11.220.442
1gy3ATPCyclin-dependent kinase 22.7.11.220.441
2btsU32Cyclin-dependent kinase 22.7.11.220.441
3qqkX02Cyclin-dependent kinase 22.7.11.220.441
3qtqX35Cyclin-dependent kinase 22.7.11.220.441
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
1p4fDRGDeath-associated protein kinase 12.7.11.10.440
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.440
4qnaX11Serine/threonine-protein kinase 242.7.11.10.440