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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.19

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.191.000
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.504
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.502
2vu3LZECyclin-dependent kinase 22.7.11.220.499
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.498
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.496
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.496
3qxpX64Cyclin-dependent kinase 22.7.11.220.496
3nynSGVG protein-coupled receptor kinase 62.7.11.160.486
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.485
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.485
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.484
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.481
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.479
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.478
2yaaATPDeath-associated protein kinase 2/0.476
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.474
3bqr4RBDeath-associated protein kinase 3/0.472
4bcmT7ZCyclin-dependent kinase 22.7.11.220.472
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.472
3at4CCKCasein kinase II subunit alpha2.7.11.10.469
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.469
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.469
1finATPCyclin-dependent kinase 22.7.11.220.466
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.466
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.466
4ansVGHALK tyrosine kinase receptor2.7.10.10.465
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.464
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.463
2zjwREFCasein kinase II subunit alpha2.7.11.10.463
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.461
3gubGUBDeath-associated protein kinase 12.7.11.10.460
4dgmAGICasein kinase II subunit alpha2.7.11.10.459
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
2j9mPY8Cyclin-dependent kinase 22.7.11.220.455
3uvqFS8Mitogen-activated protein kinase 14/0.455
3rak03ZCyclin-dependent kinase 22.7.11.220.454
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
2w05FRTCyclin-dependent kinase 22.7.11.220.453
3axwTIDCasein kinase II subunit alpha2.7.11.10.452
3be9P04Casein kinase II subunit alpha2.7.11.10.452
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.450
3ezvEZVCyclin-dependent kinase 22.7.11.220.449
3lltANPProtein serine/threonine kinase-1/0.449
2pvlP55Casein kinase II subunit alpha2.7.11.10.448
2w17I19Cyclin-dependent kinase 22.7.11.220.448
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.448
3u4uLNHCasein kinase II subunit alpha2.7.11.10.448
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.447
4dtaADNAPH(2'')-Id/0.447
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.446
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4anmWULCasein kinase II subunit alpha2.7.11.10.446
1fvv107Cyclin-dependent kinase 22.7.11.220.445
2btsU32Cyclin-dependent kinase 22.7.11.220.445
3q9xEMOCasein kinase II subunit alpha2.7.11.10.445
3rkb12ZCyclin-dependent kinase 22.7.11.220.445
3s1h56ZCyclin-dependent kinase 22.7.11.220.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3lfsA07Cyclin-dependent kinase 22.7.11.220.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
2uzbC75Cyclin-dependent kinase 22.7.11.220.443
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.443
2ijmADPFocal adhesion kinase 12.7.10.20.442
3nup3NUCyclin-dependent kinase 62.7.11.220.442
3tnwF18Cyclin-dependent kinase 22.7.11.220.442
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.442
5av4GENDeath-associated protein kinase 12.7.11.10.442
2pvmP29Casein kinase II subunit alpha2.7.11.10.441
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.441
1aq1STUCyclin-dependent kinase 22.7.11.220.440
1wvxBD4Death-associated protein kinase 12.7.11.10.440
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.440