sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2lzg | 13Q | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2lzg | 13Q | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 1.000 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.500 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.495 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.488 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.486 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.485 | |
| 4j36 | 1HR | Kynurenine 3-monooxygenase | / | 0.485 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.484 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.483 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.483 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.483 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.479 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.478 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.478 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.476 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.476 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.476 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.475 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.475 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.473 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.472 | |
| 3qly | 55V | Uncharacterized protein | / | 0.472 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.472 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.471 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.470 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.470 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.468 | |
| 4nvk | 2NY | Peroxidase | / | 0.468 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.468 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.467 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 3nta | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.466 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.466 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 1eio | GCH | Gastrotropin | / | 0.465 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.465 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.465 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.465 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.465 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.464 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.464 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.464 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.463 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.463 | |
| 3p9t | TCL | Repressor | / | 0.463 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3r8z | Z63 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.463 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.463 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.462 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.462 | |
| 4bew | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.462 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.461 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.461 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.460 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.460 | |
| 4lvg | 20O | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.460 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.459 | |
| 3d7t | STU | Tyrosine-protein kinase CSK | / | 0.459 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.459 | |
| 2bhe | BRY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3eya | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.458 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.458 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.458 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.458 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.457 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.457 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.457 | |
| 3l71 | AZO | Cytochrome b | / | 0.457 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.457 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.457 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.457 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.457 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.456 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.455 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.455 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.455 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.455 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.454 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.454 | |
| 2ydf | IO3 | Serum albumin | / | 0.454 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.454 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.454 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.454 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.454 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.453 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 1err | RAL | Estrogen receptor | / | 0.452 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.452 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3eej | 53R | Uncharacterized protein | / | 0.452 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.452 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.452 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.451 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.451 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.451 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.451 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.451 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.450 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.450 | |
| 2zju | IM4 | Acetylcholine-binding protein | / | 0.450 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.450 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3zos | 0LI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.450 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.450 | |
| 4inb | 1F6 | Gag protein | / | 0.450 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.450 | |
| 4l80 | 1VU | Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase | 4.1.3.24 | 0.450 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.449 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.449 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.449 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 2oo5 | TXD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 2wd4 | TBV | Ascorbate peroxidase | / | 0.448 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 3cse | N22 | Uncharacterized protein | / | 0.448 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.448 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.448 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.448 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.448 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 1ie4 | T44 | Transthyretin | / | 0.447 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.447 | |
| 2bxm | IMN | Serum albumin | / | 0.447 | |
| 2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.447 | |
| 3dtc | VIN | Mitogen-activated protein kinase kinase kinase 9 | 2.7.11.25 | 0.447 | |
| 3h1j | SMA | Cytochrome b | / | 0.447 | |
| 3l70 | JZV | Cytochrome b | / | 0.447 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.447 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.447 | |
| 4ucn | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1um0 | FMN | Chorismate synthase | / | 0.446 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.446 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.446 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.446 | |
| 3cp9 | C19 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.446 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.446 | |
| 5l7d | CLR | Smoothened homolog | / | 0.446 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.445 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.445 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.445 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.445 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.445 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.445 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.445 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.445 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.445 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.445 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.445 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.445 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 5bmv | VLB | Tubulin alpha-1B chain | / | 0.445 | |
| 5bmv | VLB | Tubulin beta chain | / | 0.445 | |
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 | 0.444 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1s9p | DES | Estrogen-related receptor gamma | / | 0.444 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2acw | UPG | Glycosyltransferase | / | 0.444 | |
| 2p15 | EZT | Estrogen receptor | / | 0.444 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
| 3b9l | AZZ | Serum albumin | / | 0.444 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.444 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2qjy | SMA | Cytochrome b | / | 0.443 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.443 | |
| 3eek | 53S | Uncharacterized protein | / | 0.443 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.443 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.443 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.443 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2bxo | OPB | Serum albumin | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.442 | |
| 2x3n | FAD | Probable FAD-dependent monooxygenase | / | 0.442 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.442 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.442 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.442 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1tg5 | 645 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.441 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2xvv | 9DN | Serum albumin | / | 0.441 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.441 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.441 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.441 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.440 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 3eem | 53V | Uncharacterized protein | / | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.440 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3qs8 | 17D | Anthranilate phosphoribosyltransferase | / | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.440 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.440 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.440 |