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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iki388Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2iki388Aldose reductase1.1.1.211.000
1z8962PAldose reductase1.1.1.210.793
1t40ID5Aldose reductase1.1.1.210.750
2pdmZSTAldose reductase1.1.1.210.743
2fz8ZSTAldose reductase1.1.1.210.725
2ikj393Aldose reductase1.1.1.210.688
3ld5LDTAldose reductase1.1.1.210.675
1z3n3NAAldose reductase1.1.1.210.668
2i16LDTAldose reductase1.1.1.210.666
3ghrLDTAldose reductase1.1.1.210.661
2dv0ZSTAldose reductase1.1.1.210.644
4gca2X9Aldose reductase1.1.1.210.641
2duzZSTAldose reductase1.1.1.210.636
1t41ID5Aldose reductase1.1.1.210.626
3ghsLDTAldose reductase1.1.1.210.626
2ikhLITAldose reductase1.1.1.210.625
2fz9ZSTAldose reductase1.1.1.210.624
2qxwLDTAldose reductase1.1.1.210.612
2duxZSTAldose reductase1.1.1.210.608
3lqlLDTAldose reductase1.1.1.210.607
3lboLDTAldose reductase1.1.1.210.606
3lenZSTAldose reductase1.1.1.210.606
3m4h388Aldose reductase1.1.1.210.606
3mb9ZSTAldose reductase1.1.1.210.604
2i17LDTAldose reductase1.1.1.210.602
3ghtLDTAldose reductase1.1.1.210.602
1pwlBFIAldose reductase1.1.1.210.599
3m64393Aldose reductase1.1.1.210.595
2hv5ZSTAldose reductase1.1.1.210.594
2pdfZSTAldose reductase1.1.1.210.593
2pdp393Aldose reductase1.1.1.210.592
3g5eQ74Aldose reductase1.1.1.210.585
2pdxZSTAldose reductase1.1.1.210.582
2pdh47DAldose reductase1.1.1.210.579
2pdu393Aldose reductase1.1.1.210.578
2pdc393Aldose reductase1.1.1.210.577
3mc5393Aldose reductase1.1.1.210.577
2pdg47DAldose reductase1.1.1.210.566
2pzn393Aldose reductase1.1.1.210.566
3lz5LDTAldose reductase1.1.1.210.565
1ieiZESAldose reductase1.1.1.210.564
4yu153NAldose reductase1.1.1.210.563
3ghuLDTAldose reductase1.1.1.210.557
2pdbZSTAldose reductase1.1.1.210.553
1us0LDTAldose reductase1.1.1.210.551
2pdlTOLAldose reductase1.1.1.210.549
3t423T4Aldose reductase1.1.1.210.549
2pd5ZSTAldose reductase1.1.1.210.546
2pdwFIDAldose reductase1.1.1.210.546
2pdj393Aldose reductase1.1.1.210.542
2pdn47DAldose reductase1.1.1.210.542
3m0iZSTAldose reductase1.1.1.210.540
1frbZSTAldose reductase-related protein 2/0.539
2agtFIDAldose reductase1.1.1.210.533
2fzdTOLAldose reductase1.1.1.210.531
2hvoZSTAldose reductase1.1.1.210.531
2iqdLPAAldose reductase1.1.1.210.529
2inzOHPAldose reductase1.1.1.210.522
2pdq47DAldose reductase1.1.1.210.520
1ah3TOLAldose reductase1.1.1.210.500
2f2kTGGAldose reductase1.1.1.210.482
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.477
5liu388Aldo-keto reductase family 1 member B101.1.10.477
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.474
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.472
3f3y4OABile salt sulfotransferase2.8.2.140.472
3v35NTIAldose reductase1.1.1.210.471
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.469
2pdyFIDAldose reductase1.1.1.210.468
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.464
1el3I84Aldose reductase1.1.1.210.463
4dbw511Aldo-keto reductase family 1 member C3/0.463
1ry0PG2Aldo-keto reductase family 1 member C3/0.462
2d06ESTSulfotransferase 1A12.8.2.10.462
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.458
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.458
4li61XOTankyrase-12.4.2.300.458
4xwtU5PRibonuclease J/0.458
4u163C0Muscarinic acetylcholine receptor M3/0.458
2qimZEAClass 10 plant pathogenesis-related protein/0.457
3c1oNAPEugenol synthase/0.457
3n0hTOPDihydrofolate reductase1.5.1.30.457
3u2cSUZAldose reductase1.1.1.210.457
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.454
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.453
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.452
3e4vFMNUncharacterized protein/0.452
3hl0NADMaleylacetate reductase/0.452
4phlPILPhosphodiesterase/0.452
2nvcITAAldose reductase1.1.1.210.451
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.451
5stdUNNScytalone dehydratase4.2.1.940.451
1lkeDOGBilin-binding protein/0.450
3t0kDCQSulfide-quinone reductase/0.450
3w2eFADNADH-cytochrome b5 reductase 31.6.2.20.450
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.450
2aotSAHHistamine N-methyltransferase2.1.1.80.449
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.448
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2fzbTOLAldose reductase1.1.1.210.447
2xuhTZ4Acetylcholinesterase3.1.1.70.447
4bftZVTPantothenate kinase2.7.1.330.447
4bfuZVUPantothenate kinase2.7.1.330.447
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.447
4zasTYDCalS13/0.447
1esmCOAPantothenate kinase2.7.1.330.446
1lnmDTXBilin-binding protein/0.446
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3gfbNADL-threonine 3-dehydrogenase/0.446
1x8lOXRRetinol dehydratase/0.445
1zgbA1EAcetylcholinesterase3.1.1.70.445
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.445
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.444
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2f3815MAldo-keto reductase family 1 member C3/0.444
2xlpNAPPutative flavin-containing monooxygenase/0.444
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.444
4ga8SBIAldo-keto reductase family 1 member B101.1.10.444
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2cl5BIECatechol O-methyltransferase2.1.1.60.443
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.443
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.443
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4k4eK4ETankyrase-12.4.2.300.443
1s1rNAPAldo-keto reductase family 1 member C3/0.442
1yw7A41Methionine aminopeptidase 2/0.442
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3iu9T07Methionine aminopeptidase 2/0.442
4wevSUZAldo-keto reductase family 1 member B101.1.10.442
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2xupTZ5Acetylcholinesterase3.1.1.70.441
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.441
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
1ry8RUTAldo-keto reductase family 1 member C3/0.440
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2gvcFADThiol-specific monooxygenase1.14.130.440
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.440
4q0kGA3Phytohormone-binding protein/0.440