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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a4lRRCCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2a4lRRCCyclin-dependent kinase 22.7.11.221.000
3r83Z14Cyclin-dependent kinase 22.7.11.220.598
3lfnA27Cyclin-dependent kinase 22.7.11.220.576
3r1yX76Cyclin-dependent kinase 22.7.11.220.562
3r7yZ04Cyclin-dependent kinase 22.7.11.220.561
2a0cCK9Cyclin-dependent kinase 22.7.11.220.560
3lfqA28Cyclin-dependent kinase 22.7.11.220.560
2exmZIPCyclin-dependent kinase 22.7.11.220.555
1oitHDTCyclin-dependent kinase 22.7.11.220.538
1w8cN69Cyclin-dependent kinase 22.7.11.220.536
1b38ATPCyclin-dependent kinase 22.7.11.220.534
2c6o4SPCyclin-dependent kinase 22.7.11.220.533
4fklCK2Cyclin-dependent kinase 22.7.11.220.529
1oirHDYCyclin-dependent kinase 22.7.11.220.528
4ek816KCyclin-dependent kinase 22.7.11.220.528
3qwjX6ACyclin-dependent kinase 22.7.11.220.526
3rpo24ZCyclin-dependent kinase 22.7.11.220.524
2btrU73Cyclin-dependent kinase 22.7.11.220.523
3qzgX67Cyclin-dependent kinase 22.7.11.220.518
2xmyCDKCyclin-dependent kinase 22.7.11.220.516
4fki09KCyclin-dependent kinase 22.7.11.220.510
1pxoCK7Cyclin-dependent kinase 22.7.11.220.509
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.509
3qqlX03Cyclin-dependent kinase 22.7.11.220.507
4fkt48KCyclin-dependent kinase 22.7.11.220.505
2btsU32Cyclin-dependent kinase 22.7.11.220.504
4ek610KCyclin-dependent kinase 22.7.11.220.503
4fkpLS5Cyclin-dependent kinase 22.7.11.220.502
1pxmCK5Cyclin-dependent kinase 22.7.11.220.498
1ykr628Cyclin-dependent kinase 22.7.11.220.498
4fkj11KCyclin-dependent kinase 22.7.11.220.498
1ke5LS1Cyclin-dependent kinase 22.7.11.220.496
2uzoC62Cyclin-dependent kinase 22.7.11.220.496
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.496
4fkq42KCyclin-dependent kinase 22.7.11.220.496
3r7uX96Cyclin-dependent kinase 22.7.11.220.494
1y91CT9Cyclin-dependent kinase 22.7.11.220.492
3r7vZ02Cyclin-dependent kinase 22.7.11.220.492
4kd11QKCyclin-dependent kinase 22.7.11.220.492
1hckATPCyclin-dependent kinase 22.7.11.220.491
3rahO1ZCyclin-dependent kinase 22.7.11.220.491
3rk909ZCyclin-dependent kinase 22.7.11.220.491
2b53D23Cyclin-dependent kinase 22.7.11.220.489
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.489
3s2pPMUCyclin-dependent kinase 22.7.11.220.489
3qxoX65Cyclin-dependent kinase 22.7.11.220.487
3r8vZ62Cyclin-dependent kinase 22.7.11.220.487
1e1xNW1Cyclin-dependent kinase 22.7.11.220.486
3iggEFQCyclin-dependent kinase 22.7.11.220.486
3r8lZ30Cyclin-dependent kinase 22.7.11.220.486
3rm719ZCyclin-dependent kinase 22.7.11.220.485
1w0xOLOCyclin-dependent kinase 22.7.11.220.483
4fkg4CKCyclin-dependent kinase 22.7.11.220.483
2c6kDT2Cyclin-dependent kinase 22.7.11.220.482
2r3iSCFCyclin-dependent kinase 22.7.11.220.482
1pxlCK4Cyclin-dependent kinase 22.7.11.220.481
2b52D42Cyclin-dependent kinase 22.7.11.220.481
2r3jSCJCyclin-dependent kinase 22.7.11.220.481
3rni21ZCyclin-dependent kinase 22.7.11.220.481
1h0w207Cyclin-dependent kinase 22.7.11.220.478
1ke7LS3Cyclin-dependent kinase 22.7.11.220.478
2uznC96Cyclin-dependent kinase 22.7.11.220.478
3qu0X40Cyclin-dependent kinase 22.7.11.220.475
2r3lSCWCyclin-dependent kinase 22.7.11.220.473
2w06FRVCyclin-dependent kinase 22.7.11.220.471
2vtsLZCCyclin-dependent kinase 22.7.11.220.470
3rk708ZCyclin-dependent kinase 22.7.11.220.470
1b39ATPCyclin-dependent kinase 22.7.11.220.467
3s1h56ZCyclin-dependent kinase 22.7.11.220.467
1ckpPVBCyclin-dependent kinase 22.7.11.220.466
3qzhX69Cyclin-dependent kinase 22.7.11.220.466
3rm618ZCyclin-dependent kinase 22.7.11.220.466
3sqq99ZCyclin-dependent kinase 22.7.11.220.461
1ke6LS2Cyclin-dependent kinase 22.7.11.220.460
3rjc06ZCyclin-dependent kinase 22.7.11.220.460
3lfsA07Cyclin-dependent kinase 22.7.11.220.459
3r8pZ46Cyclin-dependent kinase 22.7.11.220.459
3r9dX6BCyclin-dependent kinase 22.7.11.220.459
3r71X86Cyclin-dependent kinase 22.7.11.220.456
4acm7YGCyclin-dependent kinase 22.7.11.220.456
2vthLZ2Cyclin-dependent kinase 22.7.11.220.455
3qqhX0ACyclin-dependent kinase 22.7.11.220.455
1h0vUN4Cyclin-dependent kinase 22.7.11.220.454
2w1hL0FCyclin-dependent kinase 22.7.11.220.454
1di8DTQCyclin-dependent kinase 22.7.11.220.453
2c6lDT4Cyclin-dependent kinase 22.7.11.220.453
1h1s4SPCyclin-dependent kinase 22.7.11.220.452
2r3gSC9Cyclin-dependent kinase 22.7.11.220.452
3r1sX73Cyclin-dependent kinase 22.7.11.220.452
3r28XA0Cyclin-dependent kinase 22.7.11.220.452
4fks46KCyclin-dependent kinase 22.7.11.220.452
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.451
5aniES4Cyclin-dependent kinase 22.7.11.220.451
1g5sI17Cyclin-dependent kinase 22.7.11.220.450
1gih1PUCyclin-dependent kinase 22.7.11.220.450
1y8yCT7Cyclin-dependent kinase 22.7.11.220.450
1gii1PUCyclin-dependent kinase 22.7.11.220.449
1pyePM1Cyclin-dependent kinase 22.7.11.220.448
2c5yMTWCyclin-dependent kinase 22.7.11.220.448
2r3kSCQCyclin-dependent kinase 22.7.11.220.448
2r3o2SCCyclin-dependent kinase 22.7.11.220.446
2ds11CDCyclin-dependent kinase 22.7.11.220.445
3ddqRRCCyclin-dependent kinase 22.7.11.220.445
3ezrEZRCyclin-dependent kinase 22.7.11.220.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
3fz1B98Cyclin-dependent kinase 22.7.11.220.444
4fkv61KCyclin-dependent kinase 22.7.11.220.444
1unlRRCCyclin-dependent-like kinase 52.7.11.10.443
3ezvEZVCyclin-dependent kinase 22.7.11.220.443
3qtxX43Cyclin-dependent kinase 22.7.11.220.443
1h1r6CPCyclin-dependent kinase 22.7.11.220.441
2r3r6SCCyclin-dependent kinase 22.7.11.220.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
4bcpT3CCyclin-dependent kinase 22.7.11.220.441
4lyn1YGCyclin-dependent kinase 22.7.11.220.441
4bgh3I6Cyclin-dependent kinase 22.7.11.220.440