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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4yswFADXanthine dehydrogenase/oxidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4yswFADXanthine dehydrogenase/oxidase/1.000
1wygFADXanthine dehydrogenase/oxidase/0.615
4zohFADPutative oxidoreductase FAD-binding subunit/0.554
2c27ACOMycothiol acetyltransferase2.3.1.1890.492
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.484
1i59ANPChemotaxis protein CheA2.7.13.30.483
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.483
3u9eCOALmo1369 protein/0.482
3p7nFMNLight-activated DNA-binding protein EL222/0.477
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.476
4xj3GTPCyclic GMP-AMP synthase/0.473
4c58824Cyclin-G-associated kinase2.7.11.10.472
5awmANPStress-activated protein kinase JNK2.7.11.240.470
1j39UPGDNA beta-glucosyltransferase/0.468
2a0cCK9Cyclin-dependent kinase 22.7.11.220.468
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.468
3lfsA07Cyclin-dependent kinase 22.7.11.220.468
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.467
2z6dFMNPhototropin-22.7.11.10.467
3almFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.467
3r8vZ62Cyclin-dependent kinase 22.7.11.220.467
4l9kEHFSerum albumin/0.467
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.467
2qo9ANPEphrin type-A receptor 32.7.10.10.465
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.465
1e1xNW1Cyclin-dependent kinase 22.7.11.220.464
3r83Z14Cyclin-dependent kinase 22.7.11.220.464
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
1n9lFMNPutative blue light receptor/0.462
3qyw6PBMitogen-activated protein kinase 12.7.11.240.462
1p0hACOMycothiol acetyltransferase2.3.1.1890.461
4hj4FMNLOV protein/0.460
1drbMTXDihydrofolate reductase1.5.1.30.459
1xddAAYIntegrin alpha-L/0.459
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.459
3uzp0CKCasein kinase I isoform delta2.7.11.10.459
4xgxADPFAD:protein FMN transferase/0.459
2pdtFADVivid PAS protein VVD/0.458
3lfqA28Cyclin-dependent kinase 22.7.11.220.458
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.458
1e3eNAIAlcohol dehydrogenase 41.1.1.10.457
2uxoTACHTH-type transcriptional regulator TtgR/0.457
3oibFDAPutative acyl-CoA dehydrogenase/0.457
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.456
2qa2FADPolyketide oxygenase CabE/0.456
2znq401Peroxisome proliferator-activated receptor delta/0.456
4eeuFMNPhototropin-22.7.11.10.456
2dcnADP2-keto-3-deoxy-gluconate kinase/0.455
3cgbCOACoenzyme A disulfide reductase/0.455
3gobHXXDdmC/0.455
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.454
1levCLIFructose-1,6-bisphosphatase 13.1.3.110.454
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.454
1pxpCK8Cyclin-dependent kinase 22.7.11.220.454
1qp8NDP2-hydroxyacid dehydrogenase/0.454
2x7hPFNProstaglandin reductase 310.454
3is2FADVivid PAS protein VVD/0.454
3wfjNAD2-dehydropantoate 2-reductase/0.454
1a72PADAlcohol dehydrogenase E chain1.1.1.10.453
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.453
3cgfJNFMitogen-activated protein kinase 102.7.11.240.453
4fklCK2Cyclin-dependent kinase 22.7.11.220.453
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.453
1bwsNDPGDP-L-fucose synthase/0.452
1f20FADNitric oxide synthase, brain1.14.13.390.452
2ath3EAPeroxisome proliferator-activated receptor gamma/0.452
2pr5FMNBlue-light photoreceptor/0.452
2q5p241Peroxisome proliferator-activated receptor gamma/0.452
3vthAPCCarbamoyltransferase/0.452
3wowANPCasein kinase II subunit alpha2.7.11.10.452
5kgpACOPredicted acetyltransferase/0.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
1xkdNAPIsocitrate dehydrogenase [NADP]/0.451
3cgdCOACoenzyme A disulfide reductase/0.451
3gxlQIGTGF-beta receptor type-12.7.11.300.451
3hjiFADVivid PAS protein VVD/0.451
3nwq2NCGag-Pol polyprotein3.4.23.160.451
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.451
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.450
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.450
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.450
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
3ad9NADSubunit alpha of sarocosine oxidase/0.450
4f9fGDPPutative glycosyltransferase/0.450
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1g4tFTPThiamine-phosphate synthase/0.449
1jioDEB6-deoxyerythronolide B hydroxylase/0.449
1om1IQACasein kinase II subunit alpha2.7.11.10.449
1pxmCK5Cyclin-dependent kinase 22.7.11.220.449
2ep7NADGlyceraldehyde-3-phosphate dehydrogenase/0.449
2r3fSC8Cyclin-dependent kinase 22.7.11.220.449
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3mx2TTPNucleoprotein/0.449
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.449
4u03GTPCyclic GMP-AMP synthase/0.449
2c69CT8Cyclin-dependent kinase 22.7.11.220.448
2henADPEphrin type-B receptor 22.7.10.10.448
3icrCOACoenzyme A disulfide reductase/0.448
3rahO1ZCyclin-dependent kinase 22.7.11.220.448
4bfsZVSPantothenate kinase2.7.1.330.448
4z0hNADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic1.2.1.120.448
5eowFAD6-hydroxynicotinate 3-monooxygenase1.14.13.1140.448
1adfTADAlcohol dehydrogenase E chain1.1.1.10.447
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3jynNDPQuinone oxidoreductase/0.447
4fko20KCyclin-dependent kinase 22.7.11.220.447
4r1lADPPhenylacetate-coenzyme A ligase/0.447
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.446
3mqe416Prostaglandin G/H synthase 21.14.99.10.446
4fkq42KCyclin-dependent kinase 22.7.11.220.446
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.446
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.445
2a94AP0L-lactate dehydrogenase1.1.1.270.445
3dds26BGlycogen phosphorylase, liver form2.4.1.10.445
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.445
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.445
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.445
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2a4lRRCCyclin-dependent kinase 22.7.11.220.444
2dwbANPAurora kinase A2.7.11.10.444
2exmZIPCyclin-dependent kinase 22.7.11.220.444
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.444
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.444
3i7eDJRGag-Pol polyprotein/0.444
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
2c5yMTWCyclin-dependent kinase 22.7.11.220.443
2mwgFMNBlue-light photoreceptor/0.443
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.443
3eljGS7Mitogen-activated protein kinase 82.7.11.240.443
3zc3NAPFerredoxin--NADP reductase1.18.1.20.443
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4eos1ROCyclin-dependent kinase 22.7.11.220.443
1bygSTUTyrosine-protein kinase CSK/0.442
1zhwHC2Oxysterol-binding protein homolog 4/0.442
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.442
2zdt46CMitogen-activated protein kinase 102.7.11.240.442
3datMTXDihydrofolate reductase/0.442
3ibqATPPyridoxal kinase/0.442
3ictCOACoenzyme A disulfide reductase/0.442
3pe2E1BCasein kinase II subunit alpha2.7.11.10.442
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.442
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4hgt15GCasein kinase I isoform delta2.7.11.10.442
4nxvGDPMitochondrial dynamics protein MID51/0.442
4o4fATPKinase/0.442
4riyADPEpidermal growth factor receptor2.7.10.10.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1n9nFMNPutative blue light receptor/0.441
2oapANPType II secretion system protein (GspE-2)/0.441
3c1y2BADNA integrity scanning protein DisA/0.441
3hwrNDP2-dehydropantoate 2-reductase/0.441
3tm5SFGUncharacterized protein/0.441
4ambDUDPutative glycosyl transferase/0.441
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
4jr51LSNicotinamide phosphoribosyltransferase2.4.2.120.441
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
1g28FMNPHY3/0.440
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.440
2d52COA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.440
2q29ACOOxalyl-CoA decarboxylase4.1.1.80.440
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.440
4h9814QUncharacterized protein/0.440
4hhdFMNPhototropin-12.7.11.10.440
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.440
4ix5ANPUncharacterized protein/0.440
4ji91M3Tyrosine-protein kinase JAK2/0.440
4yaoFMNNADPH--cytochrome P450 reductase/0.440
5fklTDCTetracycline repressor protein class D/0.440