Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.88

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.881.000
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.580
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.556
2jg7NADAntiquitin/0.488
3lv1NAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.488
2iluNDPLactaldehyde dehydrogenase1.2.1.220.485
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.483
4i3vNADAldehyde dehydrogenase (NAD+)/0.483
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.482
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.481
4q71FADBifunctional protein PutA/0.481
2po7CHDFerrochelatase, mitochondrial4.99.1.10.480
4ihiNADProbable pyrroline-5-carboxylate dehydrogenase RocA/0.479
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.476
4bfzZVZPantothenate kinase2.7.1.330.475
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.473
4bfxZVXPantothenate kinase2.7.1.330.472
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.471
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.468
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
3hazNADBifunctional protein PutA/0.467
4p9dTMPDeoxycytidylate deaminase/0.467
2g1n1IGRenin3.4.23.150.465
3qe2FMNNADPH--cytochrome P450 reductase/0.465
4bfvZVVPantothenate kinase2.7.1.330.464
4pxnNADAldehyde dehydrogenase family 7 member B4/0.464
4zukNADAlpha-aminoadipic semialdehyde dehydrogenase1.2.1.310.463
1kquBR4Phospholipase A2, membrane associated/0.462
2ab8MTPAdenosine kinase2.7.1.200.462
2j6lNAIAlpha-aminoadipic semialdehyde dehydrogenase1.2.1.310.462
2vcmM11Isopenicillin N synthase1.21.3.10.462
4bfwZVWPantothenate kinase2.7.1.330.462
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.462
4bb3KKAIsopenicillin N synthase1.21.3.10.461
4r81FMNPredicted NADH dehydrogenase/0.461
3rsv3RSBeta-secretase 13.4.23.460.460
4kbyC2EStimulator of interferon genes protein/0.460
4q73FADBifunctional protein PutA/0.460
5dp2NAPCurF/0.460
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
2qs1UB1Glutamate receptor ionotropic, kainate 1/0.459
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4ktl1CQCytochrome P450/0.458
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3rhdNAPLactaldehyde dehydrogenase1.2.1.220.457
4pt3NDPAldehyde dehydrogenase/0.457
4du82P0Mevalonate diphosphate decarboxylase/0.456
4pz2NADAldehyde dehydrogenase 2-6/0.456
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.455
4jlm1NNDeoxycytidine kinase2.7.1.740.455
3fr5I4AFatty acid-binding protein, adipocyte/0.454
4bftZVTPantothenate kinase2.7.1.330.454
1f20FADNitric oxide synthase, brain1.14.13.390.453
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.453
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.453
4ipw1G7Mycocyclosin synthase1.14.21.90.453
1xddAAYIntegrin alpha-L/0.452
4u7wNDPMxaA/0.452
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.451
3own3OXRenin3.4.23.150.451
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.451
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.450
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.450
2oz57XYUncharacterized protein/0.450
3rtnRTNBeta-secretase 13.4.23.460.449
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2cdcNAPGlucose 1-dehydrogenase/0.448
2esdNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.448
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.448
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.446
2iko7IGRenin3.4.23.150.446
3to3ATPPetrobactin biosynthesis protein AsbB/0.446
4azy7F3Beta-secretase 13.4.23.460.446
4c72TLG3-oxoacyl-ACP synthase/0.446
1hfqMOTDihydrofolate reductase1.5.1.30.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.445
4bfuZVUPantothenate kinase2.7.1.330.445
4dbc3QPAspartate aminotransferase2.6.1.10.445
4itbNDPSuccinate-semialdehyde dehydrogenase/0.445
2nnqT4BFatty acid-binding protein, adipocyte/0.444
2z4sADPChromosomal replication initiator protein DnaA/0.444
3l6jZ90Alr2278 protein/0.444
4isk1JYThymidylate synthase/0.444
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
3ekuCY9Actin-5C/0.443
3wsjMK1Protease/0.443
3zkyWT4Isopenicillin N synthase1.21.3.10.443
4bfsZVSPantothenate kinase2.7.1.330.443
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.443
4e5yNDPGDP-L-fucose synthase1.1.1.2710.443
4jdcNADProbable pyrroline-5-carboxylate dehydrogenase RocA/0.443
1b2lNDCAlcohol dehydrogenase1.1.1.10.442
1c4uIH1Prothrombin3.4.21.50.442
2gvdFKPAdenylate cyclase type 2/0.442
2gvdFKPAdenylate cyclase type 5/0.442
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.442
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.442
4frkDWDBeta-secretase 13.4.23.460.442
4i9bNADPutative betaine aldehyde dehyrogenase/0.442
1eioGCHGastrotropin/0.441
2lbaCHOFatty acid binding protein 6/0.441
3pm1ETHTH-type transcriptional regulator QacR/0.441
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.441
4a81DXCMajor pollen allergen Bet v 1-A/0.441
4g3jVNTLanosterol 14-alpha-demethylase/0.441
5stdUNNScytalone dehydratase4.2.1.940.441
4zj8SUVOrexin receptor type 1/0.441
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.440
1vbiNADMalate/L-lactate dehydrogenase family protein/0.440
3br3ETHTH-type transcriptional regulator QacR/0.440
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3h4vNAPPteridine reductase 11.5.1.330.440
4ips1G4Mycocyclosin synthase1.14.21.90.440
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440