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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kin1M8Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kin1M8Mitogen-activated protein kinase 14/1.000
3ocgOCGMitogen-activated protein kinase 14/0.572
3iphG11Mitogen-activated protein kinase 14/0.554
3mpt1GKMitogen-activated protein kinase 14/0.554
2rg5279Mitogen-activated protein kinase 14/0.548
3fklFKLMitogen-activated protein kinase 14/0.546
4kip1R9Mitogen-activated protein kinase 14/0.545
3fskRO6Mitogen-activated protein kinase 14/0.538
4aa4QC0Mitogen-activated protein kinase 14/0.538
4aacAAVMitogen-activated protein kinase 14/0.535
3dt1P40Mitogen-activated protein kinase 14/0.534
4aa5NQBMitogen-activated protein kinase 14/0.534
4kiq1RAMitogen-activated protein kinase 14/0.530
4lopSB4Mitogen-activated protein kinase 14/0.529
2rg6287Mitogen-activated protein kinase 14/0.522
3l8xN4DMitogen-activated protein kinase 14/0.522
3s4qNK0Mitogen-activated protein kinase 14/0.518
3fln3FNMitogen-activated protein kinase 14/0.516
2balPQAMitogen-activated protein kinase 14/0.515
3flzFLZMitogen-activated protein kinase 14/0.513
3nww3NWMitogen-activated protein kinase 14/0.511
3hl7I47Mitogen-activated protein kinase 14/0.510
2qd9LGFMitogen-activated protein kinase 14/0.509
3u8w09JMitogen-activated protein kinase 14/0.508
1zz2B11Mitogen-activated protein kinase 14/0.500
3gfeP37Mitogen-activated protein kinase 14/0.499
4loqSB4Mitogen-activated protein kinase 14/0.498
3fi4FI4Mitogen-activated protein kinase 14/0.494
4looSB4Mitogen-activated protein kinase 14/0.494
3uvqFS8Mitogen-activated protein kinase 14/0.492
3fmh533Mitogen-activated protein kinase 14/0.491
4eh60ONMitogen-activated protein kinase 14/0.490
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.488
3flyFLYMitogen-activated protein kinase 14/0.488
2gtnLIEMitogen-activated protein kinase 14/0.486
3gc9B45Mitogen-activated protein kinase 112.7.11.240.486
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.485
2ghlLIBMitogen-activated protein kinase 14/0.482
3fmkFMKMitogen-activated protein kinase 14/0.479
1vjy460TGF-beta receptor type-12.7.11.300.476
1yw2PGJMitogen-activated protein kinase 14/0.476
1zyjBI5Mitogen-activated protein kinase 14/0.475
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.475
3uvp048Mitogen-activated protein kinase 14/0.473
2acxANPG protein-coupled receptor kinase 62.7.11.160.472
3zh8C58Protein kinase C iota type2.7.11.130.471
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.470
3flwFLWMitogen-activated protein kinase 14/0.470
3d7zGK5Mitogen-activated protein kinase 14/0.468
3bv2P38Mitogen-activated protein kinase 14/0.467
3ggpNADPrephenate dehydrogenase/0.467
3r5zF42Uncharacterized protein/0.467
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4tuvCPZCytochrome P450 1191.140.465
1rw8580TGF-beta receptor type-12.7.11.300.464
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.464
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.463
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.461
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2izuP01Casein kinase I isoform gamma-32.7.11.10.461
3uyt0CKCasein kinase I isoform delta2.7.11.10.460
3mvl38PMitogen-activated protein kinase 14/0.459
4g2fC07Ephrin type-A receptor 32.7.10.10.459
1bim0QBRenin3.4.23.150.458
2y6o1N1Ephrin type-A receptor 42.7.10.10.458
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.458
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4gk3L87Ephrin type-A receptor 32.7.10.10.458
4qnaX11Serine/threonine-protein kinase 242.7.11.10.458
1bygSTUTyrosine-protein kinase CSK/0.457
1xddAAYIntegrin alpha-L/0.457
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.457
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.457
2cig1DGDihydrofolate reductase1.5.1.30.456
3hllI45Mitogen-activated protein kinase 14/0.455
4c02TAKActivin receptor type-12.7.11.300.455
4y8wSTRSteroid 21-hydroxylase/0.455
1g1aNADdTDP-glucose 4,6-dehydratase/0.454
3mvm39PMitogen-activated protein kinase 14/0.454
4id71G0Activated CDC42 kinase 1/0.454
3vs3VSETyrosine-protein kinase HCK2.7.10.20.453
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4uyf73BBromodomain-containing protein 2/0.453
2b7aIZATyrosine-protein kinase JAK2/0.452
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.452
3bg7FADPyranose 2-oxidase/0.452
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.452
2xvdAS6Ephrin type-B receptor 42.7.10.10.451
2zb0GK3Mitogen-activated protein kinase 14/0.451
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
3nxxNDPDihydrofolate reductase1.5.1.30.451
4g3jVNTLanosterol 14-alpha-demethylase/0.451
1ie4T44Transthyretin/0.450
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.450
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.449
1u4dDBQActivated CDC42 kinase 1/0.449
2wotZZGTGF-beta receptor type-12.7.11.300.449
3bv3P39Mitogen-activated protein kinase 14/0.449
3gubGUBDeath-associated protein kinase 12.7.11.10.449
3iaeD7KBenzaldehyde lyase/0.449
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.449
1e3eNAIAlcohol dehydrogenase 41.1.1.10.448
1kzjCB3Thymidylate synthase/0.448
1ouk084Mitogen-activated protein kinase 14/0.448
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.448
3hvcGG5Mitogen-activated protein kinase 14/0.448
4gk4L90Ephrin type-A receptor 32.7.10.10.448
4jx1CAHCamphor 5-monooxygenase1.14.15.10.448
5d3qGDPDynamin-13.6.5.50.448
1ie3NADMalate dehydrogenase/0.447
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
2vx07X7Ephrin type-B receptor 42.7.10.10.447
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3k4nFADPyranose 2-oxidase/0.447
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.447
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
3b70NAPEnoyl reductase LovC10.446
3lshFADPyranose 2-oxidase/0.446
3w0hW12Vitamin D3 receptor/0.446
3znpFADD-amino-acid oxidase1.4.3.30.446
1jpaANPEphrin type-B receptor 22.7.10.10.445
1pjkANPCasein kinase II subunit alpha2.7.11.10.445
1yb5NAPQuinone oxidoreductase1.6.5.50.445
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.445
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.445
3drcMTXDihydrofolate reductase1.5.1.30.445
3gqvNAPEnoyl reductase LovC10.445
3gu83GUDeath-associated protein kinase 12.7.11.10.445
3sz0FADSulfide-quinone reductase/0.445
4e5yNDPGDP-L-fucose synthase1.1.1.2710.445
4jq8KJ8Epidermal growth factor receptor2.7.10.10.445
4jr3KJREpidermal growth factor receptor2.7.10.10.445
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
4xgiNADGlutamate dehydrogenase/0.445
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1qvnFRIInterleukin-2/0.444
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.444
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.444
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.444
3il1B5DGlutamate receptor 2/0.444
3itzP66Mitogen-activated protein kinase 14/0.444
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.444
1ida0POGag-Pol polyprotein3.4.23.470.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.443
2dteNAIGlucose 1-dehydrogenase related protein/0.443
2fzwNADAlcohol dehydrogenase class-31.1.1.10.443
3kpkFADSulfide-quinone reductase/0.443
3syiFADSulfide-quinone reductase/0.443
3t2yFADSulfide-quinone reductase/0.443
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.443
4ejmNAPPutative zinc-binding dehydrogenase/0.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
5f0a1FBcGMP-dependent protein kinase, putative/0.443
3hwrNDP2-dehydropantoate 2-reductase/0.442
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2henADPEphrin type-B receptor 22.7.10.10.441
2q5g1FAPeroxisome proliferator-activated receptor delta/0.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2vwz7X6Ephrin type-B receptor 42.7.10.10.441
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.441
2zb1GK4Mitogen-activated protein kinase 14/0.441
3lsiFADPyranose 2-oxidase/0.441
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
5e8xSTUTGF-beta receptor type-12.7.11.300.441
1c1dNAIPhenylalanine dehydrogenase/0.440
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.440
1tdfFADThioredoxin reductase1.8.1.90.440
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.440
3r83Z14Cyclin-dependent kinase 22.7.11.220.440
3t2zFADSulfide-quinone reductase/0.440
4eh70OOMitogen-activated protein kinase 14/0.440
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.440
4ji91M3Tyrosine-protein kinase JAK2/0.440
4jq7KJQEpidermal growth factor receptor2.7.10.10.440
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.440