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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ajp88NL-lactate dehydrogenase A chain1.1.1.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ajp88NL-lactate dehydrogenase A chain1.1.1.271.000
4ajo88NL-lactate dehydrogenase A chain1.1.1.270.622
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.583
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.551
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.527
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.524
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.521
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.518
1pzgA3DLactate dehydrogenase/0.518
1sowNADL-lactate dehydrogenase1.1.1.270.518
1pzfA3DLactate dehydrogenase/0.515
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.514
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.512
2a92NAIL-lactate dehydrogenase/0.508
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.507
1ie3NADMalate dehydrogenase/0.505
1zemNADXylitol dehydrogenase/0.498
1t2dNADL-lactate dehydrogenase1.1.1.270.496
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.495
5lc1NADL-threonine 3-dehydrogenase/0.493
2aa3AP0L-lactate dehydrogenase/0.490
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.488
4c4oNADSADH/0.480
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.480
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.478
5a1tNAIL-lactate dehydrogenase/0.478
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.477
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.473
4gl4NAIAlcohol dehydrogenase class-3/0.473
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.473
1adcPADAlcohol dehydrogenase E chain1.1.1.10.472
3a1nNADNDP-sugar epimerase/0.472
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.470
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.470
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.470
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.469
3ggoNAIPrephenate dehydrogenase/0.469
1g1aNADdTDP-glucose 4,6-dehydratase/0.467
4jjiNADAlcohol dehydrogenase class-3/0.465
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.465
3rj5NADAlcohol dehydrogenase1.1.1.10.464
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.464
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.464
5jlaNADPutative short-chain dehydrogenase/reductase/0.464
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.463
3cifNADGlyceraldehyde-3-phosphate dehydrogenase/0.463
3wmxNADNAD dependent epimerase/dehydratase/0.462
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.460
1h2bNAJNAD-dependent alcohol dehydrogenase/0.459
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.459
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.458
3a4vNADNDP-sugar epimerase/0.458
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.458
4gh5NADShort-chain dehydrogenase/reductase SDR/0.458
5hwsNAP2-dehydropantoate 2-reductase/0.458
1b16NAQAlcohol dehydrogenase1.1.1.10.457
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.457
1r37NADNAD-dependent alcohol dehydrogenase1.1.1.10.456
5cdsNAJAlcohol dehydrogenase E chain1.1.1.10.456
1lluNADAlcohol dehydrogenase/0.455
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.455
3l4sNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.454
3ksdNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.453
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.452
1z7eATPBifunctional polymyxin resistance protein ArnA/0.452
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.452
2yy7NADL-threonine dehydrogenase/0.452
4yagNAIC alpha-dehydrogenase/0.452
2omeNADC-terminal-binding protein 2/0.451
3ojlNADCap5O/0.451
3q2kNAIProbable oxidoreductase/0.451
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.450
3cmcNADGlyceraldehyde-3-phosphate dehydrogenase/0.448
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.447
3uxyNADShort-chain dehydrogenase/reductase SDR/0.447
4lcjNADC-terminal-binding protein 2/0.447
3f1kNAPUncharacterized oxidoreductase YciK10.446
2xaaNADSecondary alcohol dehydrogenase/0.445
3abiNADUncharacterized protein/0.445
3rj9NADAlcohol dehydrogenase1.1.1.10.445
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.445
2g5cNADPrephenate dehydrogenase/0.444
2rcyNAPPyrroline-5-carboxylate reductase/0.444
1qxsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.443
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.443
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.443
2gsdNADFormate dehydrogenase/0.443
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
3lqfNADGalactitol dehydrogenase/0.443
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.443
4xgiNADGlutamate dehydrogenase/0.443
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.442
3wdsNADNADH-dependent quinuclidinone reductase/0.442
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.441
1f8fNADBenzyl alcohol dehydrogenase/0.441
2vhvNAIAlanine dehydrogenase1.4.1.10.441
4xq9NADHomospermidine synthase2.5.1.440.441
1axeNADAlcohol dehydrogenase E chain1.1.1.10.440
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.440
1nqaNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.440
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.440
3ajrNADNDP-sugar epimerase/0.440
3ggpNADPrephenate dehydrogenase/0.440