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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3w8dNAD3-hydroxybutyrate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3w8dNAD3-hydroxybutyrate dehydrogenase/1.000
3w8fNAD3-hydroxybutyrate dehydrogenase/0.665
3w8eNAD3-hydroxybutyrate dehydrogenase/0.648
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.644
3vdqNAD3-hydroxybutyrate dehydrogenase/0.625
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.621
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.616
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.562
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.557
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.550
4b79NADProbable short-chain dehydrogenase/0.545
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.537
2dteNAIGlucose 1-dehydrogenase related protein/0.536
1w4zNAPPutative ketoacyl reductase1.3.10.532
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.530
3gy0NAPNAD(P)-dependent oxidoreductase/0.528
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.525
1ae1NAPTropinone reductase 1/0.523
1x7hNDPPutative ketoacyl reductase1.3.10.523
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.523
4j7xNAPSepiapterin reductase1.1.1.1530.523
5jlaNADPutative short-chain dehydrogenase/reductase/0.520
3qrwNDPPutative ketoacyl reductase1.3.10.518
1ipeNDPTropinone reductase 21.1.1.2360.515
1xkqNDPUncharacterized protein/0.515
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.514
4dc1NDPPutative ketoacyl reductase1.3.10.514
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.513
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.513
4j7uNAPSepiapterin reductase1.1.1.1530.510
2wdzNADGalactitol dehydrogenase/0.507
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.507
1n5dNDPCarbonyl reductase [NADPH] 1/0.506
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.506
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.506
1oaaNAPSepiapterin reductase1.1.1.1530.505
1pr9NAPL-xylulose reductase1.1.1.100.505
3sjuNDPKeto reductase/0.505
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.505
4qecNAPElxO/0.504
1xg5NAPDehydrogenase/reductase SDR family member 11/0.503
1zemNADXylitol dehydrogenase/0.503
3p19NDPPutative blue fluorescent protein/0.502
1iy8NADLevodione reductase/0.501
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.501
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.501
1x7gNAPPutative ketoacyl reductase1.3.10.500
4yaiNAIC alpha-dehydrogenase/0.500
1rwbNADGlucose 1-dehydrogenase1.1.1.470.498
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.498
4gh5NADShort-chain dehydrogenase/reductase SDR/0.497
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.496
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.496
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.496
1g6kNADGlucose 1-dehydrogenase1.1.1.470.495
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.495
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.493
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.493
4bmvNAPShort-chain dehydrogenase/0.493
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.492
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.491
2jahNDPClavaldehyde dehydrogenase/0.491
4hwkNAPSepiapterin reductase1.1.1.1530.491
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.491
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.490
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.489
4impNDPPolyketide synthase extender modules 3-4/0.489
5idwNAPShort-chain dehydrogenase/reductase SDR/0.489
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.488
3toxNAPPutative oxidoreductase/0.488
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.487
1gcoNADGlucose 1-dehydrogenase1.1.1.470.487
3ai2NDPNADPH-sorbose reductase/0.487
3ak4NADNADH-dependent quinuclidinone reductase/0.487
4nbwNADShort-chain dehydrogenase/reductase SDR/0.487
4yagNAIC alpha-dehydrogenase/0.487
2bd0NAPSepiapterin reductase/0.486
2yutNAPPutative short-chain oxidoreductase/0.486
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.486
1sbyNADAlcohol dehydrogenase1.1.1.10.485
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.485
1wntNAPL-xylulose reductase1.1.1.100.484
3d3wNAPL-xylulose reductase1.1.1.100.484
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.483
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.483
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.482
1mg5NAIAlcohol dehydrogenase1.1.1.10.481
2wsbNADGalactitol dehydrogenase/0.481
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.481
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.480
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.479
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.479
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
3f1kNAPUncharacterized oxidoreductase YciK10.478
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.478
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.476
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
3uxyNADShort-chain dehydrogenase/reductase SDR/0.474
4fn4NADShort chain dehydrogenase/0.474
5lc1NADL-threonine 3-dehydrogenase/0.474
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.473
3wdsNADNADH-dependent quinuclidinone reductase/0.473
1b15NAEAlcohol dehydrogenase1.1.1.10.472
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.470
3l77NJPShort-chain alcohol dehydrogenase/0.470
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.470
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.468
2p5uNADUDP-glucose 4-epimerase/0.466
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.464
1geeNADGlucose 1-dehydrogenase1.1.1.470.464
3lqfNADGalactitol dehydrogenase/0.464
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.463
3ai3NDPNADPH-sorbose reductase/0.463
3rj5NADAlcohol dehydrogenase1.1.1.10.463
4esoNAPPutative oxidoreductase/0.463
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.462
3rj9NADAlcohol dehydrogenase1.1.1.10.462
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1snyNAPLD36273p/0.460
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.456
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.455
1b16NAQAlcohol dehydrogenase1.1.1.10.454
1rkxNADCDP-D-glucose-4,6-dehydratase/0.451
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.451
5emhNAPIridoid synthase1.3.1.990.450
3a4vNADNDP-sugar epimerase/0.449
4e5yNDPGDP-L-fucose synthase1.1.1.2710.448
4qedNAPElxO/0.448
3s55NADPutative short-chain dehydrogenase/reductase/0.447
3tscNADUncharacterized protein/0.447
5jydNADShort chain dehydrogenase/0.447
2yy7NADL-threonine dehydrogenase/0.446
3uceNDPDehydrogenase/0.445
4b8wNAPGDP-L-fucose synthase1.1.1.2710.445
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3r3sNADPutative oxidoreductase/0.443
3tn7NJPShort-chain alcohol dehydrogenase/0.443
4b8zNAPGDP-L-fucose synthase1.1.1.2710.443
3u4cNDPNADPH-dependent reductase BacG/0.442
2c0cNAPProstaglandin reductase 310.441
3bmoNAPPteridine reductase/0.440
3ggoNAIPrephenate dehydrogenase/0.440
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.440