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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3p0pNNFTankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3p0pNNFTankyrase-22.4.2.301.000
3kr8XAVTankyrase-22.4.2.300.652
4l0i1UWTankyrase-22.4.2.300.642
4iueAJ4Tankyrase-22.4.2.300.637
4l33F70Tankyrase-22.4.2.300.636
4l0t1V0Tankyrase-22.4.2.300.635
4hkkAGITankyrase-22.4.2.300.633
4hlf15ZTankyrase-22.4.2.300.632
4bueJQFTankyrase-22.4.2.300.631
4bu908CTankyrase-22.4.2.300.629
4l321VFTankyrase-22.4.2.300.629
4buxF35Tankyrase-22.4.2.300.623
4bufF36Tankyrase-22.4.2.300.621
4bus32FTankyrase-22.4.2.300.620
4buuF38Tankyrase-22.4.2.300.618
4l341VGTankyrase-22.4.2.300.610
4bs4A64Tankyrase-22.4.2.300.609
4l0v1V1Tankyrase-22.4.2.300.607
4kzl20DTankyrase-22.4.2.300.606
4l10A63Tankyrase-22.4.2.300.600
4hl515WTankyrase-22.4.2.300.598
4l0s1UZTankyrase-22.4.2.300.597
4l2g1V4Tankyrase-22.4.2.300.597
4l2f1V3Tankyrase-22.4.2.300.595
4hlk431Tankyrase-22.4.2.300.593
4krs1SXTankyrase-12.4.2.300.593
4buiW2ETankyrase-22.4.2.300.591
4hlh20DTankyrase-22.4.2.300.591
4but31FTankyrase-22.4.2.300.588
4buwF33Tankyrase-22.4.2.300.586
4hmhF94Tankyrase-22.4.2.300.579
5aku29FTankyrase-22.4.2.300.578
4j22AJ7Tankyrase-22.4.2.300.577
4l2k1V8Tankyrase-22.4.2.300.577
4avwG18Tankyrase-22.4.2.300.573
4j21AJ6Tankyrase-22.4.2.300.571
4hkiFLNTankyrase-22.4.2.300.570
4hknLU2Tankyrase-22.4.2.300.561
4pnrG18Tankyrase-22.4.2.300.560
4hlm16STankyrase-22.4.2.300.555
4tkg09LTankyrase-22.4.2.300.555
4bud29FTankyrase-22.4.2.300.553
4kzuA73Tankyrase-22.4.2.300.537
4l091URTankyrase-22.4.2.300.532
4bj9UHBTankyrase-22.4.2.300.530
4hlg20BTankyrase-22.4.2.300.530
4msk2C8Tankyrase-12.4.2.300.527
4j3lAJ5Tankyrase-22.4.2.300.521
4bjbP34Tankyrase-22.4.2.300.520
4l31F08Tankyrase-22.4.2.300.510
4hyf1AKTankyrase-22.4.2.300.504
4tjy3GNTankyrase-22.4.2.300.502
4li61XOTankyrase-12.4.2.300.496
4j3mAJ8Tankyrase-22.4.2.300.489
2bfaCB3Pteridine reductase 11.5.1.330.488
4pnmNU1Tankyrase-22.4.2.300.488
3rsv3RSBeta-secretase 13.4.23.460.484
4buv16ITankyrase-22.4.2.300.482
2bf7HBIPteridine reductase 11.5.1.330.471
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.468
1xf0ASDAldo-keto reductase family 1 member C3/0.467
4avuLDRTankyrase-22.4.2.300.467
1xk9P34Exotoxin A2.4.2.360.466
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4fam0SZAldo-keto reductase family 1 member C3/0.464
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.463
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.463
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.462
1synF89Thymidylate synthase/0.460
4li81XQTankyrase-12.4.2.300.460
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.459
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.453
4gbrCAUBeta-2 adrenergic receptor/0.453
3i2834NBifunctional epoxide hydrolase 23.3.2.100.452
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.452
1c7oPPGHemolysin/0.450
3h4vDVPPteridine reductase 11.5.1.330.450
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.447
1amoFMNNADPH--cytochrome P450 reductase/0.446
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.446
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
1e92HBIPteridine reductase 11.5.1.330.443
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.443
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.442
4bb3KKAIsopenicillin N synthase1.21.3.10.442
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.441
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.441
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.441
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.441
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.441
4hcy0YNTransketolase/0.441
4u140HKMuscarinic acetylcholine receptor M3/0.441
1krv147Galactoside O-acetyltransferase2.3.1.180.440
1odcA8BAcetylcholinesterase3.1.1.70.440
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.440
1x8lOXRRetinol dehydratase/0.440