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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/1.000
2jahNDPClavaldehyde dehydrogenase/0.541
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.538
2wsbNADGalactitol dehydrogenase/0.529
4gh5NADShort-chain dehydrogenase/reductase SDR/0.526
5jydNADShort chain dehydrogenase/0.526
4j7xNAPSepiapterin reductase1.1.1.1530.525
1ae1NAPTropinone reductase 1/0.522
1n5dNDPCarbonyl reductase [NADPH] 1/0.522
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.522
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.521
1oaaNAPSepiapterin reductase1.1.1.1530.520
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.517
4j7uNAPSepiapterin reductase1.1.1.1530.517
3w8eNAD3-hydroxybutyrate dehydrogenase/0.516
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.513
4hwkNAPSepiapterin reductase1.1.1.1530.511
3s55NADPutative short-chain dehydrogenase/reductase/0.510
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.507
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.507
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.506
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.506
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.506
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.506
1iy8NADLevodione reductase/0.505
3vdqNAD3-hydroxybutyrate dehydrogenase/0.505
2yutNAPPutative short-chain oxidoreductase/0.504
2wdzNADGalactitol dehydrogenase/0.503
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.503
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.501
3d3wNAPL-xylulose reductase1.1.1.100.501
3sjuNDPKeto reductase/0.501
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.501
1xkqNDPUncharacterized protein/0.500
5jlaNADPutative short-chain dehydrogenase/reductase/0.500
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.499
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.499
4yagNAIC alpha-dehydrogenase/0.499
1pr9NAPL-xylulose reductase1.1.1.100.498
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.498
5idwNAPShort-chain dehydrogenase/reductase SDR/0.498
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.497
1xg5NAPDehydrogenase/reductase SDR family member 11/0.496
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.496
3w8fNAD3-hydroxybutyrate dehydrogenase/0.496
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.496
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.495
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.494
4yaiNAIC alpha-dehydrogenase/0.494
3wdsNADNADH-dependent quinuclidinone reductase/0.492
2dteNAIGlucose 1-dehydrogenase related protein/0.491
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.490
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.488
1x7gNAPPutative ketoacyl reductase1.3.10.488
3ak4NADNADH-dependent quinuclidinone reductase/0.488
4fn4NADShort chain dehydrogenase/0.488
3lqfNADGalactitol dehydrogenase/0.487
3w8dNAD3-hydroxybutyrate dehydrogenase/0.487
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.487
4qecNAPElxO/0.487
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.486
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.486
4nbwNADShort-chain dehydrogenase/reductase SDR/0.486
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.484
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.483
4bmvNAPShort-chain dehydrogenase/0.483
1wntNAPL-xylulose reductase1.1.1.100.482
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.481
1zemNADXylitol dehydrogenase/0.480
5ig2NADShort-chain dehydrogenase/reductase SDR/0.480
3gy0NAPNAD(P)-dependent oxidoreductase/0.479
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.478
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.478
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.478
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.477
3r3sNADPutative oxidoreductase/0.476
4b79NADProbable short-chain dehydrogenase/0.476
3toxNAPPutative oxidoreductase/0.474
1ipeNDPTropinone reductase 21.1.1.2360.473
1w4zNAPPutative ketoacyl reductase1.3.10.473
2bd0NAPSepiapterin reductase/0.473
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.473
5lc1NADL-threonine 3-dehydrogenase/0.473
3l77NJPShort-chain alcohol dehydrogenase/0.472
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.471
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.471
3p19NDPPutative blue fluorescent protein/0.470
3sx2NADUncharacterized protein/0.469
1i3lNADUDP-glucose 4-epimerase/0.468
1snyNAPLD36273p/0.468
4dc1NDPPutative ketoacyl reductase1.3.10.468
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.467
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.467
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.466
2yy7NADL-threonine dehydrogenase/0.466
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.466
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.465
3qrwNDPPutative ketoacyl reductase1.3.10.465
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.464
1x7hNDPPutative ketoacyl reductase1.3.10.462
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.462
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.461
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.460
3uceNDPDehydrogenase/0.459
1geeNADGlucose 1-dehydrogenase1.1.1.470.457
3rj9NADAlcohol dehydrogenase1.1.1.10.457
5jy1NADPutative short-chain dehydrogenase/reductase/0.457
1kvrNADUDP-glucose 4-epimerase5.1.3.20.456
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.456
1gcoNADGlucose 1-dehydrogenase1.1.1.470.454
1rwbNADGlucose 1-dehydrogenase1.1.1.470.454
1g6kNADGlucose 1-dehydrogenase1.1.1.470.453
3a1nNADNDP-sugar epimerase/0.453
1naiNADUDP-glucose 4-epimerase5.1.3.20.452
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3uxyNADShort-chain dehydrogenase/reductase SDR/0.450
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.449
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.449
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.448
1mg5NAIAlcohol dehydrogenase1.1.1.10.447
3tn7NJPShort-chain alcohol dehydrogenase/0.447
3tscNADUncharacterized protein/0.447
1sbyNADAlcohol dehydrogenase1.1.1.10.444
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.444
1b15NAEAlcohol dehydrogenase1.1.1.10.443
4idgNADPutative UDP-glucose 4-epimerase/0.443
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.443
3rj5NADAlcohol dehydrogenase1.1.1.10.442
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.442
3a4vNADNDP-sugar epimerase/0.441
2p5uNADUDP-glucose 4-epimerase/0.440
3ai2NDPNADPH-sorbose reductase/0.440