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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hucG97Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hucG97Mitogen-activated protein kinase 14/1.000
3zsgT75Mitogen-activated protein kinase 14/0.594
3gcpSB2Mitogen-activated protein kinase 14/0.563
3zs5SB2Mitogen-activated protein kinase 14/0.508
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.496
2ewaSB2Mitogen-activated protein kinase 14/0.491
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.487
1bl6SB6Mitogen-activated protein kinase 14/0.476
2g263LGRenin3.4.23.150.475
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
3t8xT8XT-cell surface glycoprotein CD1b/0.475
1ouk084Mitogen-activated protein kinase 14/0.474
3jx3JI5Nitric oxide synthase, brain1.14.13.390.474
1q5dEPBEpothilone C/D epoxidase1.140.471
3qm4PN0Cytochrome P450 2D6/0.470
4jsfQJ4Nitric oxide synthase, brain1.14.13.390.470
2y4gTIRTamL/0.468
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.468
4h3j10WBeta-secretase 13.4.23.460.466
3png8CXNitric oxide synthase, brain1.14.13.390.464
1ia3TQ5Dihydrofolate reductase1.5.1.30.463
1x8lOXRRetinol dehydratase/0.463
3mdmFJZCholesterol 24-hydroxylase/0.462
4b78KGGBeta-secretase 13.4.23.460.460
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
2w71L23Biotin carboxylase6.3.4.140.459
1krv147Galactoside O-acetyltransferase2.3.1.180.458
2y3rTRKTamL/0.458
2y3sTIRTamL/0.458
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.458
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2g274LGRenin3.4.23.150.457
3gcq1BUMitogen-activated protein kinase 14/0.457
3hv3R49Mitogen-activated protein kinase 14/0.457
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
1jipKTN6-deoxyerythronolide B hydroxylase/0.456
2dhfDZFDihydrofolate reductase1.5.1.30.456
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3l8sBFFMitogen-activated protein kinase 14/0.455
3tdaPN0Cytochrome P450 2D6/0.455
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
1fmlRTLRetinol dehydratase/0.454
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.454
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.453
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.453
4enhFVXCholesterol 24-hydroxylase/0.453
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.452
2y3rTIRTamL/0.451
4bfsZVSPantothenate kinase2.7.1.330.451
3g6zA7TRenin3.4.23.150.450
3p3zP3ZPutative cytochrome P450/0.450
4x5iFOLDihydrofolate reductase1.5.1.30.450
1pkfEPDEpothilone C/D epoxidase1.140.449
3cv9VDXVitamin D3 dihydroxylase/0.449
3rqmX2ENitric oxide synthase, brain1.14.13.390.449
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1m13HYFNuclear receptor subfamily 1 group I member 2/0.448
3nlqJRRNitric oxide synthase, brain1.14.13.390.448
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.448
4rn615UProthrombin3.4.21.50.448
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.447
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
4cx4HW9Nitric oxide synthase, brain1.14.13.390.447
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.447
4fhf0TTSpore photoproduct lyase/0.447
4rh10TTSpore photoproduct lyase/0.447
4ryvZEAProtein LlR18A/0.447
1ddsMTXDihydrofolate reductase1.5.1.30.446
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.446
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.446
4h3g10QBeta-secretase 13.4.23.460.446
1ddrMTXDihydrofolate reductase1.5.1.30.445
1qiqACCIsopenicillin N synthase1.21.3.10.445
2uxoTACHTH-type transcriptional regulator TtgR/0.445
4bb3KKAIsopenicillin N synthase1.21.3.10.445
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.444
3qeoLLTDeoxycytidine kinase2.7.1.740.444
3ufuHW8Nitric oxide synthase, brain1.14.13.390.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
1dhjMTXDihydrofolate reductase1.5.1.30.443
1uzwCDHIsopenicillin N synthase1.21.3.10.443
1ywrLI9Mitogen-activated protein kinase 14/0.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.443
1drfFOLDihydrofolate reductase1.5.1.30.442
1ia4TQ6Dihydrofolate reductase1.5.1.30.442
4g1nNZTPyruvate kinase PKM2.7.1.400.442
4q71FADBifunctional protein PutA/0.442
1dhfFOLDihydrofolate reductase1.5.1.30.441
1x1aSAMC-20 methyltransferase/0.441
2drcMTXDihydrofolate reductase1.5.1.30.441
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.441
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
4h3f10OBeta-secretase 13.4.23.460.441
1cqp803Integrin alpha-L/0.440
1g63FMNEpidermin decarboxylase4.1.10.440
3g72A6TRenin3.4.23.150.440
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.440
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.440
4jbtASDCytochrome P450 monooxygenase/0.440