sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ght | LDT | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.869 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.863 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.828 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.815 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.755 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.736 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.729 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.719 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.718 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.703 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.693 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.683 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.679 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.677 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.645 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.637 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.635 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.632 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.621 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.618 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.616 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.616 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.597 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.596 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.595 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.595 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.592 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.592 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.587 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.585 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.584 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.584 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.582 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.581 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.577 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.576 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.574 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.572 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.572 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.562 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.557 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.556 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.551 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.549 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.549 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.539 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.529 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.526 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.526 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.520 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.519 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.515 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.506 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.504 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.502 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.497 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.496 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.494 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.488 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.487 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.485 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.480 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.480 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.474 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.473 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.471 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.469 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.467 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.467 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.466 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.465 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.465 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.464 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.463 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.461 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.460 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.459 | |
| 4xwt | U5P | Ribonuclease J | / | 0.459 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.459 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.457 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.456 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.455 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.455 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.453 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.453 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.453 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.453 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.452 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.452 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.451 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.451 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.450 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.448 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.448 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.448 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.448 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.447 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.447 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4h6p | FMN | Chromate reductase | / | 0.447 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.446 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.446 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 1fml | RTL | Retinol dehydratase | / | 0.445 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.445 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.445 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.445 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.444 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.444 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.443 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.443 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.443 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.443 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.443 | |
| 1s36 | CEI | Obelin | / | 0.442 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.442 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.441 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.441 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.440 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4hcy | 0YN | Transketolase | / | 0.440 | |
| 4kmz | FOL | Folate receptor beta | / | 0.440 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.440 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.440 |