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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.71.000
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.581
4q0kGA3Phytohormone-binding protein/0.513
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.511
1pqc444Oxysterols receptor LXR-beta/0.493
2xuoTZ4Acetylcholinesterase3.1.1.70.489
2xukTZ5Acetylcholinesterase3.1.1.70.487
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.482
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.482
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.482
2getCOKPantothenate kinase2.7.1.330.481
2xugTZ4Acetylcholinesterase3.1.1.70.480
4bftZVTPantothenate kinase2.7.1.330.479
2j3qTFLAcetylcholinesterase3.1.1.70.477
2w6cBM4Acetylcholinesterase3.1.1.70.477
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.477
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.477
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.476
2ckmAA7Acetylcholinesterase3.1.1.70.476
2jl1NAPTriphenylmethane reductase/0.476
2xupTZ5Acetylcholinesterase3.1.1.70.475
3aezGDPPantothenate kinase2.7.1.330.475
1ry8RUTAldo-keto reductase family 1 member C3/0.474
1w76GNTAcetylcholinesterase3.1.1.70.474
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.474
2xuhTZ4Acetylcholinesterase3.1.1.70.474
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.473
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.473
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.472
4h7c10HAldo-keto reductase family 1 member C3/0.472
1esmCOAPantothenate kinase2.7.1.330.471
3f3y4OABile salt sulfotransferase2.8.2.140.470
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.470
4m0f1YKAcetylcholinesterase3.1.1.70.470
2geuCOKPantothenate kinase2.7.1.330.468
4arbC57Acetylcholinesterase3.1.1.70.468
1q23FUAChloramphenicol acetyltransferase2.3.1.280.467
2gesCOKPantothenate kinase2.7.1.330.467
2jf0HBPAcetylcholinesterase3.1.1.70.467
3af3GCPPantothenate kinase2.7.1.330.467
1q84TZ4Acetylcholinesterase3.1.1.70.466
2wu4HBPAcetylcholinesterase3.1.1.70.466
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.466
1q83TZ5Acetylcholinesterase3.1.1.70.465
3qe2FMNNADPH--cytochrome P450 reductase/0.465
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.465
2zsaADPPantothenate kinase2.7.1.330.464
3af0GDPPantothenate kinase2.7.1.330.464
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.464
1eveE20Acetylcholinesterase3.1.1.70.463
2g263LGRenin3.4.23.150.463
2xufTZ4Acetylcholinesterase3.1.1.70.463
3b9oFMNAlkane monoxygenase/0.463
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.463
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.463
4b7zQ4QAcetylcholinesterase3.1.1.70.463
1u65CP0Acetylcholinesterase3.1.1.70.462
1xf0ASDAldo-keto reductase family 1 member C3/0.461
1zgbA1EAcetylcholinesterase3.1.1.70.461
2cekN8TAcetylcholinesterase3.1.1.70.461
2fzbTOLAldose reductase1.1.1.210.461
2ha6SCKAcetylcholinesterase3.1.1.70.461
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.461
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.461
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.460
2fs4PZ1Renin3.4.23.150.460
2g274LGRenin3.4.23.150.460
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.460
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.460
1ut6A8NAcetylcholinesterase3.1.1.70.459
2zsbADPPantothenate kinase2.7.1.330.459
3n0hTOPDihydrofolate reductase1.5.1.30.459
1odcA8BAcetylcholinesterase3.1.1.70.458
2g1o2IGRenin3.4.23.150.458
2xuqTZ4Acetylcholinesterase3.1.1.70.458
3g70A5TRenin3.4.23.150.458
3o9lLPNRenin3.4.23.150.458
3oadLPORenin3.4.23.150.458
2xi4AFTAcetylcholinesterase3.1.1.70.457
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
2bn4FMNNADPH--cytochrome P450 reductase/0.456
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.456
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.455
4u140HKMuscarinic acetylcholine receptor M3/0.455
2aouCQAHistamine N-methyltransferase2.1.1.80.454
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.454
4ey7E20Acetylcholinesterase3.1.1.70.454
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.454
4xwtU5PRibonuclease J/0.454
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.454
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.453
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.453
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
2wjoQUDBeta-secretase 13.4.23.460.452
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.452
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.452
4uthFMNXenobiotic reductase/0.452
1ffyMRCIsoleucine--tRNA ligase6.1.1.50.451
1h22E10Acetylcholinesterase3.1.1.70.451
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.451
1ry0PG2Aldo-keto reductase family 1 member C3/0.451
1w4lGL8Acetylcholinesterase3.1.1.70.451
3r8hZOMAldo-keto reductase family 1 member C3/0.451
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1zgcA2EAcetylcholinesterase3.1.1.70.450
2xujTZ5Acetylcholinesterase3.1.1.70.450
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3g72A6TRenin3.4.23.150.450
3k1wBFXRenin3.4.23.150.450
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4cb593GPolymerase basic protein 2/0.450
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.449
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
3n14FMNXenobiotic reductase/0.449
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.449
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.449
1bk0ACVIsopenicillin N synthase1.21.3.10.448
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.448
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.448
3af1GDPPantothenate kinase2.7.1.330.448
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.448
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.448
3rsv3RSBeta-secretase 13.4.23.460.448
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.448
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.448
4fizCUE17beta-hydroxysteroid dehydrogenase/0.448
4rvfTYDD-mycarose 3-C-methyltransferase/0.448
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.447
1s63778Protein farnesyltransferase subunit beta2.5.1.580.447
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2vrbNAPTriphenylmethane reductase/0.447
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.447
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.447
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.447
4psbGA3Cytokinin-specific binding protein/0.447
2pb1NFGGlucan 1,3-beta-glucosidase/0.446
2z1qFADAcyl-CoA dehydrogenase/0.446
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.446
4nv14TGFormyl transferase/0.446
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.445
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.445
2zsdCOAPantothenate kinase2.7.1.330.445
3af2ACPPantothenate kinase2.7.1.330.445
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.444
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.444
2vt4P32Beta-1 adrenergic receptor/0.444
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.444
3af4GCPPantothenate kinase2.7.1.330.444
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3q7fED2Uncharacterized protein/0.444
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.444
3ufl508Beta-secretase 13.4.23.460.444
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3uonQNBMuscarinic acetylcholine receptor M2/0.444
1zq5E04Aldo-keto reductase family 1 member C3/0.443
3nljH4BNitric oxide synthase, brain1.14.13.390.443
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.443
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.443
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.442
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.442
3hl0NADMaleylacetate reductase/0.442
3junAKDPhenazine biosynthesis protein A/B/0.442
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4a86H35Major pollen allergen Bet v 1-A/0.442
1d9i00PProthrombin3.4.21.50.441
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.441
1nm6L86Prothrombin3.4.21.50.441
2bktRPFRenin3.4.23.150.441
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.441
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.441
3uweVJJAldo-keto reductase family 1 member C3/0.441
4a16H34Acetylcholinesterase3.1.1.70.441
4jpg1OXPyruvate kinase PKM2.7.1.400.441
4nv10FXFormyl transferase/0.441
4uy6SAHHistidine N-alpha-methyltransferase/0.441
5d5aCAUBeta-2 adrenergic receptor/0.441
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.440
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.440
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.440
3g6zA7TRenin3.4.23.150.440
3s5wFADL-ornithine N(5)-monooxygenase/0.440
5depUD1Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.440