sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fkn | FKN | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.793 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.773 | |
| 3fmm | XI2 | Mitogen-activated protein kinase 14 | / | 0.759 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.626 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.619 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.614 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.609 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.581 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.581 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.553 | |
| 3fls | FLS | Mitogen-activated protein kinase 14 | / | 0.545 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.541 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.537 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.536 | |
| 3fmk | FMK | Mitogen-activated protein kinase 14 | / | 0.524 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.518 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.509 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.507 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.506 | |
| 3fml | FML | Mitogen-activated protein kinase 14 | / | 0.506 | |
| 3fi4 | FI4 | Mitogen-activated protein kinase 14 | / | 0.504 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 3fmj | FMJ | Mitogen-activated protein kinase 14 | / | 0.499 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.498 | |
| 3fmh | 533 | Mitogen-activated protein kinase 14 | / | 0.497 | |
| 3rin | I2O | Mitogen-activated protein kinase 14 | / | 0.494 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.493 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.493 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.493 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.487 | |
| 3fmn | 530 | Mitogen-activated protein kinase 14 | / | 0.485 | |
| 3roc | 29A | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 3flz | FLZ | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.481 | |
| 3mpa | SB2 | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 1syn | F89 | Thymidylate synthase | / | 0.476 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.476 | |
| 1zdw | FLV | Prenyltransferase | / | 0.475 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.475 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.473 | |
| 1ouk | 084 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 1m7q | DQO | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.470 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.469 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.468 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.465 | |
| 4loo | SB4 | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 3fc1 | 52P | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.464 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.463 | |
| 1ppj | ANY | Cytochrome b | / | 0.462 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.462 | |
| 3ha8 | 5JZ | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.461 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.460 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.459 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.457 | |
| 4dlj | 6RG | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.457 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.454 | |
| 1f28 | F89 | Thymidylate synthase | 2.1.1.45 | 0.453 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.453 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.453 | |
| 4eh5 | 0OM | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.453 | |
| 4y0k | NAP | AntE | / | 0.453 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.453 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.453 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.452 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.452 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 1wbw | LI4 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.451 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.450 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.449 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.448 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.448 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.448 | |
| 1jut | LYD | Thymidylate synthase | / | 0.447 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 1u0h | ONM | Adenylate cyclase type 2 | / | 0.447 | |
| 1u0h | ONM | Adenylate cyclase type 5 | / | 0.447 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.447 | |
| 5doz | NDP | JamJ | / | 0.447 | |
| 1bh5 | GTX | Lactoylglutathione lyase | 4.4.1.5 | 0.446 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.446 | |
| 1z2i | NAD | Putative malate dehydrogenase | / | 0.446 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.446 | |
| 2pvy | ACP | Fibroblast growth factor receptor 2 | / | 0.446 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 4lb2 | DM5 | Serum albumin | / | 0.446 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.446 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.445 | |
| 2yis | I46 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.445 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.445 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.445 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4phl | PIL | Phosphodiesterase | / | 0.445 | |
| 5bn4 | ANP | V-type ATP synthase alpha chain | / | 0.445 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.444 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.444 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.444 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.444 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.444 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.443 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4ybn | FAD | Flavin-nucleotide-binding protein | / | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.441 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3vnt | 0JA | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 4bec | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.441 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.441 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.441 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.440 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.440 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.440 |