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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xjjL81Heat shock protein HSP 90-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xjjL81Heat shock protein HSP 90-alpha/1.000
4jqlVJ6Heat shock protein HSP 90-alpha/0.577
2fwyH64Heat shock protein HSP 90-alpha/0.562
2xabVHDHeat shock protein HSP 90-alpha/0.562
1yetGDMHeat shock protein HSP 90-alpha/0.554
3d0bSNXHeat shock protein HSP 90-alpha/0.553
3k974CDHeat shock protein HSP 90-alpha/0.553
2xhtC0YHeat shock protein HSP 90-alpha/0.549
1osfKOSHeat shock protein HSP 90-alpha/0.547
2xjxXJXHeat shock protein HSP 90-alpha/0.546
3ekrPY9Heat shock protein HSP 90-alpha/0.541
2wi6ZZ6Heat shock protein HSP 90-alpha/0.540
1yc14BCHeat shock protein HSP 90-alpha/0.539
1uy8PU5Heat shock protein HSP 90-alpha/0.537
2h55DZ8Heat shock protein HSP 90-alpha/0.531
4b7p9UNHeat shock protein HSP 90-alpha/0.531
2iwsNP4ATP-dependent molecular chaperone HSP82/0.529
2qg0A94Heat shock protein HSP 90-alpha/0.529
3o0iP54Heat shock protein HSP 90-alpha/0.528
1yc34BCHeat shock protein HSP 90-alpha/0.527
2byh2D7Heat shock protein HSP 90-alpha/0.527
3k981RCHeat shock protein HSP 90-alpha/0.527
4xcjADPHeat shock cognate 90 kDa protein/0.525
4asg814ATP-dependent molecular chaperone HSP82/0.524
4ipeANPTNF receptor-associated protein 1/0.524
1uy7PU4Heat shock protein HSP 90-alpha/0.523
2fwzH71Heat shock protein HSP 90-alpha/0.523
2vcj2EQHeat shock protein HSP 90-alpha/0.523
3vhaVHAHeat shock protein HSP 90-alpha/0.523
2iorADPChaperone protein HtpG/0.522
2wi5ZZ5Heat shock protein HSP 90-alpha/0.522
4xclAGSHeat shock cognate 90 kDa protein/0.522
2bt0CT5Heat shock protein HSP 90-alpha/0.521
3r4pFU7Heat shock protein HSP 90-alpha/0.520
2byi2DDHeat shock protein HSP 90-alpha/0.518
1byqADPHeat shock protein HSP 90-alpha/0.517
1uyiPUZHeat shock protein HSP 90-alpha/0.515
2bsmBSMHeat shock protein HSP 90-alpha/0.515
3whaWHAHeat shock protein HSP 90-alpha/0.514
3k99PFTHeat shock protein HSP 90-alpha/0.512
2yee2ECHeat shock protein HSP 90-alpha/0.511
3hekBD0Heat shock protein HSP 90-alpha/0.511
2wi1ZZ2Heat shock protein HSP 90-alpha/0.510
3ekoPYUHeat shock protein HSP 90-alpha/0.510
3hz142CHeat shock protein HSP 90-alpha/0.509
1uy9PU6Heat shock protein HSP 90-alpha/0.507
1uyePU9Heat shock protein HSP 90-alpha/0.507
4ivgANPTNF receptor-associated protein 1/0.506
3hz5Z64Heat shock protein HSP 90-alpha/0.505
3mnrSD1Heat shock protein HSP 90-alpha/0.505
3r4oFU3Heat shock protein HSP 90-alpha/0.505
4egh0OYHeat shock protein HSP 90-alpha/0.505
1uykPUXHeat shock protein HSP 90-alpha/0.504
2qg2A91Heat shock protein HSP 90-alpha/0.504
2iwuNP5ATP-dependent molecular chaperone HSP82/0.503
4xdmGDMHeat shock cognate 90 kDa protein/0.503
2yejZZ3Heat shock protein HSP 90-alpha/0.501
4egkRDCHeat shock protein HSP 90-alpha/0.501
2vci2GJHeat shock protein HSP 90-alpha/0.499
3hyz42CHeat shock protein HSP 90-alpha/0.499
1y4sADPChaperone protein HtpG/0.497
4asf62UATP-dependent molecular chaperone HSP82/0.497
2yjwYJWHeat shock protein HSP 90-alpha/0.495
4efuEFUHeat shock protein HSP 90-alpha/0.495
1uyfPU1Heat shock protein HSP 90-alpha/0.493
2xd6XD6ATP-dependent molecular chaperone HSP82/0.493
3omuIBDHeat shock protein 83/0.493
4ce17FKATP-dependent molecular chaperone HSP82/0.491
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.489
2bz5AB4Heat shock protein HSP 90-alpha/0.486
1uyhPU0Heat shock protein HSP 90-alpha/0.485
1yc443PHeat shock protein HSP 90-alpha/0.485
3r4nFU5Heat shock protein HSP 90-alpha/0.485
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.483
3rlq3RQHeat shock protein HSP 90-alpha/0.483
4nmbFADBifunctional protein PutA/0.483
2wi72KLHeat shock protein HSP 90-alpha/0.480
2yeiXQIHeat shock protein HSP 90-alpha/0.480
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.480
2yefANPHeat shock protein HSP 90-alpha/0.479
3qdd94MHeat shock protein HSP 90-alpha/0.479
2vwcBC2ATP-dependent molecular chaperone HSP82/0.478
3pejBC2Endoplasmin homolog, putative/0.478
1amwADPATP-dependent molecular chaperone HSP82/0.477
3o6o94MHeat shock protein 83/0.477
4fcr0TMHeat shock protein HSP 90-alpha/0.477
2breKJ2ATP-dependent molecular chaperone HSP82/0.476
2oapANPType II secretion system protein (GspE-2)/0.475
2ykbYKBHeat shock protein HSP 90-alpha/0.475
1uycPU7Heat shock protein HSP 90-alpha/0.474
3ft5MO8Heat shock protein HSP 90-alpha/0.474
3q5lKX2Heat shock protein 83-1/0.473
2xjgXJGHeat shock protein HSP 90-alpha/0.471
4egiB2JHeat shock protein HSP 90-alpha/0.471
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.470
2xk2ADPHeat shock protein HSP 90-alpha/0.469
2yegXQGHeat shock protein HSP 90-alpha/0.468
2wi2ZZ3Heat shock protein HSP 90-alpha/0.466
1uydPU8Heat shock protein HSP 90-alpha/0.464
2yk2YJWHeat shock protein HSP 90-alpha/0.464
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.464
2uwd2GGHeat shock protein HSP 90-alpha/0.463
2wi4ZZ4Heat shock protein HSP 90-alpha/0.463
3c11GDMATP-dependent molecular chaperone HSP82/0.463
2yi7BZ8Heat shock protein HSP 90-alpha/0.462
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.461
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
3iedAN2HSP90/0.460
3ii43IIDihydrolipoyl dehydrogenase1.8.1.40.459
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.459
4xj43ATCyclic GMP-AMP synthase/0.459
2cgfP2NATP-dependent molecular chaperone HSP82/0.458
2ye42FYHeat shock protein HSP 90-alpha/0.458
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.458
3v9v21LPeroxisome proliferator-activated receptor gamma/0.458
5dhhDGWNociceptin receptor/0.458
2fypRDEEndoplasmin/0.457
3lqfNADGalactitol dehydrogenase/0.457
3s1dZIRCytokinin dehydrogenase 11.5.99.120.457
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
2qfoA13Heat shock protein HSP 90-alpha/0.456
2cct2E1Heat shock protein HSP 90-alpha/0.455
2xcmADPCytosolic heat shock protein 90/0.455
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.455
3u9eCOALmo1369 protein/0.455
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.455
1v9aSAHUncharacterized protein/0.454
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.453
3kb1ADPIron-sulfur cluster carrier protein/0.453
3l63CAMCamphor 5-monooxygenase1.14.15.10.453
4tuvCPZCytochrome P450 1191.140.453
1oguST8Cyclin-dependent kinase 22.7.11.220.452
2yi66QMHeat shock protein HSP 90-alpha/0.452
3k9vCPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial/0.452
3opdHIEHeat shock protein 83/0.452
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.452
1jioDEB6-deoxyerythronolide B hydroxylase/0.451
1oiuN76Cyclin-dependent kinase 22.7.11.220.451
1zrzBI1Protein kinase C iota type2.7.11.130.451
2ccu2D9Heat shock protein HSP 90-alpha/0.451
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.450
2esaGDMEndoplasmin/0.450
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.450
4bcpT3CCyclin-dependent kinase 22.7.11.220.450
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.450
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.449
2zbaZBATrichothecene 3-O-acetyltransferase/0.449
3a62STURibosomal protein S6 kinase beta-12.7.11.10.449
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.449
4f650S9Fibroblast growth factor receptor 1/0.448
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.448
5ej5TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.448
5ejaTD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.448
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.447
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
3triNAPPyrroline-5-carboxylate reductase/0.447
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.447
4dc0NDPPutative ketoacyl reductase1.3.10.447
4ipw1G7Mycocyclosin synthase1.14.21.90.447
5a3bAPRSIR2 family protein/0.447
1eupASD6-deoxyerythronolide B hydroxylase/0.446
1h1s4SPCyclin-dependent kinase 22.7.11.220.446
3inxJZCHeat shock protein HSP 90-alpha/0.446
3s2pPMUCyclin-dependent kinase 22.7.11.220.446
4q71FADBifunctional protein PutA/0.446
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2ohvNHLGlutamate racemase/0.445
2oxtSAMGenome polyprotein/0.445
2r64740Cyclin-dependent kinase 22.7.11.220.445
2ye92D4Heat shock protein HSP 90-alpha/0.445
3ezrEZRCyclin-dependent kinase 22.7.11.220.445
3gw9VNILanosterol 14-alpha-demethylase/0.445
4g3rCAMCamphor 5-monooxygenase1.14.15.10.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
1ijhFADCholesterol oxidase1.1.3.60.444
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2w1fL0FAurora kinase A2.7.11.10.444
3cgdNADCoenzyme A disulfide reductase/0.444
3dds26BGlycogen phosphorylase, liver form2.4.1.10.444
3lfqA28Cyclin-dependent kinase 22.7.11.220.444
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.444
4ly91YYGlucokinase regulatory protein/0.444
1oiyN41Cyclin-dependent kinase 22.7.11.220.443
1unlRRCCyclin-dependent-like kinase 52.7.11.10.443
1yb5NAPQuinone oxidoreductase1.6.5.50.443
2jn3JN3Fatty acid-binding protein, liver/0.443
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.443
3zuyTCHTransporter/0.443
2o1uANPEndoplasmin/0.442
2oa1FADFlavin-dependent tryptophan halogenase RebH1.14.19.90.442
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
4ktl1CQCytochrome P450/0.442
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
1a72PADAlcohol dehydrogenase E chain1.1.1.10.441
1fmjRTLRetinol dehydratase/0.441
1i59ANPChemotaxis protein CheA2.7.13.30.441
1ke6LS2Cyclin-dependent kinase 22.7.11.220.441
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441
2bfyH1NAurora kinase B-A2.7.11.10.441
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.441
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.441
3l8p0CEAngiopoietin-1 receptor2.7.10.10.441
3mdmFJZCholesterol 24-hydroxylase/0.441
4fkw62KCyclin-dependent kinase 22.7.11.220.441
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
4r21STRCytochrome P450 family 17 polypeptide 2/0.441
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
1t85CAMCamphor 5-monooxygenase1.14.15.10.440
2xru400Aurora kinase A2.7.11.10.440
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.440
3d75NBBPheromone-binding protein ASP1/0.440
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.440
3fln3FNMitogen-activated protein kinase 14/0.440
3sqq99ZCyclin-dependent kinase 22.7.11.220.440
4a99FADTetX family tetracycline inactivation enzyme/0.440
4qmySTUSerine/threonine-protein kinase 242.7.11.10.440