scPDB - Distribution of Binding site Similarity values of 2wbb entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2wbb	RO3	Fructose-1,6-bisphosphatase 1	3.1.3.11

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2wbb	RO3	Fructose-1,6-bisphosphatase 1	3.1.3.11	1.000
2wbd	RO5	Fructose-1,6-bisphosphatase 1	3.1.3.11	0.618
2y5k	YCU	Fructose-1,6-bisphosphatase 1	3.1.3.11	0.561
2fhy	A37	Fructose-1,6-bisphosphatase 1	3.1.3.11	0.549
1xe5	5FE	Plasmepsin-2	3.4.23.39	0.521
2vhw	NAI	Alanine dehydrogenase	1.4.1.1	0.491
1hdc	CBO	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	1.1.1.53	0.482
4q73	FAD	Bifunctional protein PutA	/	0.480
2ahr	NAP	Pyrroline-5-carboxylate reductase	/	0.474
4bge	PYW	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.473
2voj	NAD	Alanine dehydrogenase	1.4.1.1	0.470
3mpj	FAD	Glutaryl-CoA dehydrogenase	1.3.99.32	0.470
3syi	FAD	Sulfide-quinone reductase	/	0.466
2npa	MMB	Peroxisome proliferator-activated receptor alpha	/	0.465
2xhd	7T9	Glutamate receptor 2	/	0.464
4q71	FAD	Bifunctional protein PutA	/	0.463
1a72	PAD	Alcohol dehydrogenase E chain	1.1.1.1	0.462
3r7k	FDA	Probable acyl CoA dehydrogenase	/	0.462
2vhv	NAI	Alanine dehydrogenase	1.4.1.1	0.461
3bc3	OPT	Cathepsin L1	3.4.22.15	0.461
2vhz	NAI	Alanine dehydrogenase	1.4.1.1	0.460
3zuy	TCH	Transporter	/	0.460
4gxs	0YS	Glutamate receptor 2	/	0.460
4z34	ON7	Lysophosphatidic acid receptor 1	/	0.460
1yb5	NAP	Quinone oxidoreductase	1.6.5.5	0.459
2q5g	1FA	Peroxisome proliferator-activated receptor delta	/	0.459
1c1d	NAI	Phenylalanine dehydrogenase	/	0.458
1t0l	NAP	Isocitrate dehydrogenase [NADP] cytoplasmic	1.1.1.42	0.458
1xdd	AAY	Integrin alpha-L	/	0.458
3icr	COA	Coenzyme A disulfide reductase	/	0.458
1e5q	NDP	Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]	1.5.1.10	0.457
2uuv	FAD	Alkyldihydroxyacetonephosphate synthase	2.5.1.26	0.456
3cid	318	Beta-secretase 1	3.4.23.46	0.456
3nf4	FAD	Acyl-CoA dehydrogenase domain-containing protein	/	0.456
3sp6	IL2	Peroxisome proliferator-activated receptor alpha	/	0.456
4g7g	VFV	Lanosterol 14-alpha-demethylase	/	0.456
4qxr	1YE	Stimulator of interferon genes protein	/	0.456
3ajr	NAD	NDP-sugar epimerase	/	0.455
3fql	79Z	Genome polyprotein	2.7.7.48	0.455
3kpk	FAD	Sulfide-quinone reductase	/	0.455
3imx	B84	Glucokinase	2.7.1.2	0.454
4g3j	VNT	Lanosterol 14-alpha-demethylase	/	0.454
1g2k	NM1	Gag-Pol polyprotein	3.4.23.16	0.453
2vhx	NAD	Alanine dehydrogenase	1.4.1.1	0.453
3gw9	VNI	Lanosterol 14-alpha-demethylase	/	0.453
3t2y	FAD	Sulfide-quinone reductase	/	0.453
4c7k	NAP	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.453
2gtm	LID	Mitogen-activated protein kinase 14	/	0.452
2oor	NAD	NAD(P) transhydrogenase subunit alpha part 1	1.6.1.2	0.452
3a9w	NAD	NDP-sugar epimerase	/	0.452
3e2s	FAD	Bifunctional protein PutA	1.5.5.2	0.452
3f46	I2C	5,10-methenyltetrahydromethanopterin hydrogenase	1.12.98.2	0.452
3sz0	FAD	Sulfide-quinone reductase	/	0.452
4kby	C2E	Stimulator of interferon genes protein	/	0.452
1f8f	NAD	Benzyl alcohol dehydrogenase	/	0.451
1vik	BAY	Gag-Pol polyprotein	/	0.451
3cty	FAD	Probable thioredoxin reductase	/	0.451
2nru	T12	Interleukin-1 receptor-associated kinase 4	2.7.11.1	0.450
3fcj	FAD	Nitroalkane oxidase	1.7.3.1	0.450
3ics	COA	Coenzyme A disulfide reductase	/	0.450
4eud	COA	Succinyl-CoA:acetate CoA-transferase	/	0.450
4nmd	FDA	Bifunctional protein PutA	/	0.450
5hws	NAP	2-dehydropantoate 2-reductase	/	0.450
1tj0	FAD	Bifunctional protein PutA	1.5.5.2	0.449
1w5v	BE3	Gag-Pol polyprotein	3.4.23.16	0.449
2rcy	NAP	Pyrroline-5-carboxylate reductase	/	0.449
3em0	CHD	Fatty acid-binding protein 6, ileal (gastrotropin)	/	0.449
1xq6	NAP	Uncharacterized protein At5g02240	/	0.448
4r21	STR	Cytochrome P450 family 17 polypeptide 2	/	0.448
2cmj	NAP	Isocitrate dehydrogenase [NADP] cytoplasmic	1.1.1.42	0.447
3b70	NAP	Enoyl reductase LovC	1	0.447
3lpj	Z75	Beta-secretase 1	3.4.23.46	0.447
3w8w	FAD	Putative FAD-dependent oxygenase EncM	/	0.447
1uuo	BRF	Dihydroorotate dehydrogenase (quinone), mitochondrial	1.3.5.2	0.446
1xl5	190	Gag-Pol polyprotein	3.4.23.16	0.446
2f7x	4EA	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.446
4bgi	I4I	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.446
4ejn	0R4	RAC-alpha serine/threonine-protein kinase	2.7.11.1	0.446
5koi	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.446
1hsk	FAD	UDP-N-acetylenolpyruvoylglucosamine reductase	/	0.445
3v9y	24L	Peroxisome proliferator-activated receptor gamma	/	0.445
4a6b	QG8	Gag-Pol polyprotein	3.4.23.16	0.445
4bf2	STU	Mitogen-activated protein kinase kinase kinase 5	2.7.11.25	0.445
1jq5	NAD	Glycerol dehydrogenase	1.1.1.6	0.444
1udy	FAD	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	1.3.8.7	0.444
2hdj	NDP	Aldo-keto reductase family 1 member C2	/	0.444
2i4z	DRH	Peroxisome proliferator-activated receptor gamma	/	0.444
2p83	MR0	Beta-secretase 1	3.4.23.46	0.444
2ylz	FAD	Phenylacetone monooxygenase	1.14.13.92	0.444
2znn	S44	Peroxisome proliferator-activated receptor alpha	/	0.444
3tqh	NDP	Quinone oxidoreductase	/	0.444
4kio	G5K	Tyrosine-protein kinase ITK/TSK	2.7.10.2	0.444
5doz	NDP	JamJ	/	0.444
1mp0	NAD	Alcohol dehydrogenase class-3	1.1.1.1	0.443
1tj2	FAD	Bifunctional protein PutA	1.5.5.2	0.443
2fw3	BUI	Carnitine O-palmitoyltransferase 2, mitochondrial	2.3.1.21	0.443
2rbe	NDP	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.443
2wes	FAD	Tryptophan 5-halogenase	/	0.443
2z54	AB1	Gag-Pol polyprotein	3.4.23.16	0.443
3aid	ARQ	Gag-Pol polyprotein	3.4.23.16	0.443
5af7	FAD	Acyl-CoA dehydrogenase	/	0.443
5eb5	FAD	(R)-mandelonitrile lyase 1	4.1.2.10	0.443
2c0i	L1G	Tyrosine-protein kinase HCK	2.7.10.2	0.442
2hfp	NSI	Peroxisome proliferator-activated receptor gamma	/	0.442
2p3b	3TL	V-1 PROTEASE protein	/	0.442
2p3b	3TL	V-1 protease	/	0.442
3cic	316	Beta-secretase 1	3.4.23.46	0.442
3u33	FAD	Putative acyl-CoA dehydrogenase AidB	1.3.99	0.442
3v5l	0G1	Tyrosine-protein kinase ITK/TSK	2.7.10.2	0.442
4jvf	17X	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	/	0.442
4njv	RIT	Protease	/	0.442
4z24	FAD	Putative GMC-type oxidoreductase R135	1	0.442
1eby	BEB	Gag-Pol polyprotein	3.4.23.16	0.441
1kr2	TAD	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1	2.7.7.1	0.441
1u28	NAD	NAD(P) transhydrogenase subunit alpha part 1	1.6.1.2	0.441
2f4b	EHA	Peroxisome proliferator-activated receptor gamma	/	0.441
3w8d	NAD	3-hydroxybutyrate dehydrogenase	/	0.441
4bca	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.441
4dpl	NAP	Malonyl-CoA reductase	1.2.1.75	0.441
4e5y	NDP	GDP-L-fucose synthase	1.1.1.271	0.441
4kb9	G79	Protease	/	0.441
4kl9	NDP	Dihydrofolate reductase	1.5.1.3	0.441
4l03	NAP	Isocitrate dehydrogenase [NADP] cytoplasmic	1.1.1.42	0.441
4q72	FAD	Bifunctional protein PutA	/	0.441
1sst	COA	Serine acetyltransferase	2.3.1.30	0.440
2amt	1AA	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	4.6.1.12	0.440
2c0c	NAP	Prostaglandin reductase 3	1	0.440
2eba	FAD	Putative glutaryl-CoA dehydrogenase	/	0.440
2q63	1UN	Gag-Pol polyprotein	3.4.23.16	0.440
2qfx	NDP	Isocitrate dehydrogenase [NADP], mitochondrial	1.1.1.42	0.440
2y46	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.440
3t2z	FAD	Sulfide-quinone reductase	/	0.440
4x28	FDA	Acyl-CoA dehydrogenase FadE26	/	0.440
4x28	FDA	Acyl-CoA dehydrogenase FadE27	/	0.440