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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2oy0SAHGenome polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2oy0SAHGenome polyprotein/1.000
3ivgFG5Pantothenate synthetase6.3.2.10.483
3lm9ADPPutative fructokinase2.7.1.40.482
3qvsNADMyo-inositol-1-phosphate synthase (Ino1)/0.481
5ero210Fusicoccadiene synthase2.5.1.290.481
4xvuATPATPase GET3/0.479
4yqfGDPSeptin-9/0.477
3c35KAIGlutamate receptor ionotropic, kainate 1/0.472
4dpwAGSMevalonate diphosphate decarboxylase/0.468
1esqTZPHydroxyethylthiazole kinase/0.467
4g3pUD1Bifunctional protein GlmU/0.467
3isjA8DPantothenate synthetase6.3.2.10.466
4z17PEPEnolase/0.464
3h03UBPGlutamate receptor 2/0.463
3imeBZ2Pantothenate synthetase6.3.2.10.463
5cyoGDPSeptin-9/0.463
2f6rACOBifunctional coenzyme A synthase/0.462
1k8y13PTryptophan synthase alpha chain/0.461
1touB1VFatty acid-binding protein, adipocyte/0.461
4i02CMPcAMP-activated global transcriptional regulator CRP/0.461
3oe9ITDC-X-C chemokine receptor type 4/0.461
1p4aPCPPur operon repressor/0.459
1sxjAGSReplication factor C subunit 1/0.458
1rfqLARActin, alpha skeletal muscle/0.457
4de50JDPantothenate synthetase6.3.2.10.456
5cypGSPSeptin-9/0.456
1j21ATPArgininosuccinate synthase/0.455
1rdwLARActin, alpha skeletal muscle/0.455
1kfcIPLTryptophan synthase alpha chain/0.454
2db3ANPATP-dependent RNA helicase vasa, isoform A3.6.4.130.454
3rbaCODPhosphopantetheine adenylyltransferase/0.454
2cmoM1LGlutamate receptor 2/0.453
5k7uSAMN6-adenosine-methyltransferase 70 kDa subunit/0.453
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.452
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.452
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.452
4z54GDPNeuronal-specific septin-3/0.452
1kp8AGS60 kDa chaperonin/0.451
4z875GPInosine-5'-monophosphate dehydrogenase/0.451
5b0oADPFlagellum-specific ATP synthase3.6.3.140.451
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.450
3dzvADPHydroxyethylthiazole kinase/0.450
3imgBZ3Pantothenate synthetase6.3.2.10.449
1hbvGANGag-Pol polyprotein/0.448
1nhpFADNADH peroxidase1.11.1.10.448
3coy53HPantothenate synthetase6.3.2.10.448
3lnc5GPGuanylate kinase/0.448
3m4p4ADAsparaginyl-tRNA synthetase, putative/0.448
1o76CAMCamphor 5-monooxygenase1.14.15.10.447
1xduSFGAclacinomycin 10-hydroxylase RdmB4.1.10.447
3qttANPPantothenate synthetase/0.447
5kwvANPPantothenate synthetase/0.447
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4px9ADPATP-dependent RNA helicase DDX3X3.6.4.130.446
1twwHH2Dihydropteroate synthase/0.445
1vi2NADQuinate/shikimate dehydrogenase/0.445
2b51UTPRNA editing complex protein MP57/0.445
1odx0E8Gag-Pol polyprotein3.4.23.160.444
1p9wANPType II secretion system protein E/0.444
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.444
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.444
1yp4ADQGlucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic2.7.7.270.443
2a7r5GPGMP reductase 2/0.443
2q1l8823-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.443
3t7qRB4Endothiapepsin3.4.23.220.443
3udq09EBeta-secretase 13.4.23.460.443
4cojCTPUncharacterized protein/0.443
4lj8ADPChaperone protein ClpB/0.443
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.443
1lb9DNQGlutamate receptor 2/0.442
1m6iFADApoptosis-inducing factor 1, mitochondrial1.1.10.442
1omoNADAlanine dehydrogenase/0.442
1sqkLARActin, alpha skeletal muscle/0.442
1u7hNADPutative ornithine cyclodeaminase/0.442
2fzkCTPAspartate carbamoyltransferase regulatory chain/0.442
3imgBZ2Pantothenate synthetase6.3.2.10.442
3ioeA7DPantothenate synthetase6.3.2.10.442
3ivxFG6Pantothenate synthetase6.3.2.10.442
3p0hFSEPutative tyrosyl-tRNA synthetase/0.442
3srzUPGToxin A/0.442
4tx9AMZPhosphoribosyl isomerase A/0.442
5hg0SAMPantothenate synthetase/0.442
1v9aSAHUncharacterized protein/0.441
3emdSFGMethyltransferase/0.441
2oapANPType II secretion system protein (GspE-2)/0.440
2v5uFMNFlavodoxin/0.440
2v8pADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
3l7dDK5Glycogen phosphorylase, muscle form2.4.1.10.440
4la7A1OAbscisic acid receptor PYL2/0.440
5d3qGDPDynamin-13.6.5.50.440