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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hxzH7JCathepsin S3.4.22.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hxzH7JCathepsin S3.4.22.271.000
2g7yMO9Cathepsin S3.4.22.270.529
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.489
2uxoTACHTH-type transcriptional regulator TtgR/0.475
4s1iPLPPyridoxal kinase, putative/0.475
1e79ATPATP synthase subunit alpha, mitochondrial/0.471
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.471
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.470
4ips1G4Mycocyclosin synthase1.14.21.90.470
1xddAAYIntegrin alpha-L/0.469
3q9bB3NAcetylpolyamine amidohydrolase/0.466
2ejzSAHDiphthine synthase/0.465
2nr4FMNConserved protein/0.464
2hldANPATP synthase subunit alpha, mitochondrial/0.463
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.463
3g5hYTTMycocyclosin synthase1.14.21.90.463
3mpeN2ACathepsin S3.4.22.270.463
4ktl1CQCytochrome P450/0.463
4d7eFADPutative lysine-N-oxygenase/0.461
1b2lNDCAlcohol dehydrogenase1.1.1.10.460
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4b4w9L9Bifunctional protein FolD/0.460
4bfxZVXPantothenate kinase2.7.1.330.460
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.459
1tojHCIAspartate aminotransferase2.6.1.10.458
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.458
3hl0NADMaleylacetate reductase/0.457
4ict1EDMycocyclosin synthase1.14.21.90.457
4y1bNAPAntE/0.457
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.456
2gv8NDPThiol-specific monooxygenase1.14.130.455
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.454
4g47TZFMycocyclosin synthase1.14.21.90.454
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.452
3fr5I4AFatty acid-binding protein, adipocyte/0.452
1mewXMPInosine-5'-monophosphate dehydrogenase/0.450
3iktNADRedox-sensing transcriptional repressor Rex/0.450
3p99LNPLanosterol 14-alpha-demethylase/0.450
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.450
1towCRZFatty acid-binding protein, adipocyte/0.449
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
4c717RD3-oxoacyl-ACP synthase/0.449
5hs1VORLanosterol 14-alpha demethylase/0.449
1lb9DNQGlutamate receptor 2/0.448
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.448
3qiyQI1Botulinum neurotoxin type A3.4.24.690.448
4bfzZVZPantothenate kinase2.7.1.330.448
2vn1FK5Peptidylprolyl isomerase/0.447
2wd8VGFPteridine reductase/0.447
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.447
1yc2NADNAD-dependent protein deacylase 2/0.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2gevCOKPantothenate kinase2.7.1.330.445
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.445
3ixp834Ecdysone receptor/0.445
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.444
3br3ETHTH-type transcriptional regulator QacR/0.444
3qgf46FGenome polyprotein2.7.7.480.444
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
4bftZVTPantothenate kinase2.7.1.330.444
1fmlRTLRetinol dehydratase/0.443
1rdt570Peroxisome proliferator-activated receptor gamma/0.443
1ygkRRCPyridoxal kinase2.7.1.350.443
2vrbNAPTriphenylmethane reductase/0.443
4bfuZVUPantothenate kinase2.7.1.330.443
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2g226IGRenin3.4.23.150.442
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3jv7NADSecondary alcohol dehydrogenase/0.441
3l77NJPShort-chain alcohol dehydrogenase/0.441
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
4q73FADBifunctional protein PutA/0.441
5ab6CAANonspecific lipid-transfer protein, putative/0.441
4zj8SUVOrexin receptor type 1/0.441
1o9bNAIQuinate/shikimate dehydrogenase/0.440
1toiHCIAspartate aminotransferase2.6.1.10.440
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.440
3c1oNAPEugenol synthase/0.440
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4b4vL34Bifunctional protein FolD/0.440
4b65FADL-ornithine N(5)-monooxygenase/0.440
4usrFADMonooxygenase/0.440