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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hfnFMNActivator of photopigment and puc expression

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hfnFMNActivator of photopigment and puc expression/1.000
2bycFMNBlue-light receptor of the BLUF-family/0.587
2hfoFMNActivator of photopigment and puc expression/0.571
1x0pFADTll0078 protein/0.569
3mziFMNActivator of photopigment and puc expression/0.566
3gfzFMNUncharacterized protein/0.563
3gg1FMNUncharacterized protein/0.557
3gfxFMNUncharacterized protein/0.554
3gfyFMNUncharacterized protein/0.548
4yusFMNFamily 3 adenylate cyclase/0.544
3gg0FMNUncharacterized protein/0.543
1yrxFMNAppA protein/0.497
4yutFMNFamily 3 adenylate cyclase/0.485
4s32ANPMitogen-activated protein kinase 12.7.11.240.484
2iyiFMNAppA, antirepressor of ppsR, sensor of blue light/0.483
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.483
3tdvGDPGentamicin resistance protein/0.477
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.474
4hh0FMNAppA protein/0.474
2kb2FMNUncharacterized protein/0.467
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.466
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.464
3tdwGDPGentamicin resistance protein/0.464
1cm8ANPMitogen-activated protein kinase 12/0.463
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.463
4gk3L87Ephrin type-A receptor 32.7.10.10.462
2iygFMNAppA, antirepressor of ppsR, sensor of blue light/0.460
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.460
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.458
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.457
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.455
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.455
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.454
1csnATPCasein kinase I homolog 12.7.11.10.453
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.453
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4xlvACPInsulin receptor2.7.10.10.453
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.452
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.452
4gu610NFocal adhesion kinase 12.7.10.20.452
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
3nnxEDDMitogen-activated protein kinase 14/0.451
3r7vZ02Cyclin-dependent kinase 22.7.11.220.451
3gc9B45Mitogen-activated protein kinase 112.7.11.240.450
3ztxZTXAurora kinase B-A2.7.11.10.450
4riyADPEpidermal growth factor receptor2.7.10.10.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.449
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4fcwADPChaperone protein ClpB/0.449
5ez4NADBetaine-aldehyde dehydrogenase/0.449
2pmlANPUncharacterized protein/0.448
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.448
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.448
4s33ANPMitogen-activated protein kinase 12.7.11.240.448
1ir3ANPInsulin receptor2.7.10.10.447
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.447
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.447
3datMTXDihydrofolate reductase/0.447
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.447
1h1q2A6Cyclin-dependent kinase 22.7.11.220.446
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.446
2q6bHR23-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.446
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3gcuR48Mitogen-activated protein kinase 14/0.445
3nnuEDBMitogen-activated protein kinase 14/0.445
4crsAGSSerine/threonine-protein kinase N22.7.11.130.445
4dieC5PCytidylate kinase/0.445
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2pmnK51Protein kinase 7/0.444
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.444
2yyuC5POrotidine 5'-phosphate decarboxylase/0.444
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3opdHIEHeat shock protein 83/0.444
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.443
2eb3ANPEpidermal growth factor receptor2.7.10.10.443
2r4fRIE3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.443
3clyACPFibroblast growth factor receptor 2/0.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.442
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.442
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.442
3sjzGNPTranslation initiation factor 2 subunit gamma/0.442
3vi2HMZOrotidine 5'-monophosphate decarboxylase/0.442
3vjoANPEpidermal growth factor receptor2.7.10.10.442
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.442
4i4e1BQFocal adhesion kinase 12.7.10.20.442
1u3cFADCryptochrome-1/0.441
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.441
2itqITQEpidermal growth factor receptor2.7.10.10.441
2przOMPOrotate phosphoribosyltransferase 12.4.2.100.441
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.441
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.441
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
5iqfGDPBifunctional AAC/APH2.3.10.441
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
4eomATPCyclin-dependent kinase 22.7.11.220.440
4g3pUD1Bifunctional protein GlmU/0.440
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.440
4nmdFDABifunctional protein PutA/0.440