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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ceaADPATP-dependent zinc metalloprotease FtsH

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ceaADPATP-dependent zinc metalloprotease FtsH/1.000
4kodADPTransitional endoplasmic reticulum ATPase3.6.4.60.546
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.531
2ce7ADPATP-dependent zinc metalloprotease FtsH/0.524
4ww0ADPATP-dependent zinc metalloprotease FtsH/0.518
3hu3AGSTransitional endoplasmic reticulum ATPase3.6.4.60.510
4ko8AGSTransitional endoplasmic reticulum ATPase3.6.4.60.502
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.498
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.497
1zrzBI1Protein kinase C iota type2.7.11.130.471
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
1ia4TQ6Dihydrofolate reductase1.5.1.30.468
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.465
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.464
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.463
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.463
2xvv9DNSerum albumin/0.462
4nxvGDPMitochondrial dynamics protein MID51/0.462
1s3sADPTransitional endoplasmic reticulum ATPase3.6.4.60.461
1w1rZEACytokinin dehydrogenase 11.5.99.120.461
2b53D23Cyclin-dependent kinase 22.7.11.220.461
3kq7KQ7Mitogen-activated protein kinase 14/0.461
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.461
2xvw9NRSerum albumin/0.459
4djaFAD(6-4) photolyase/0.458
4rphFADUDP-galactopyranose mutase5.4.99.90.458
3ddw055Glycogen phosphorylase, liver form2.4.1.10.457
3vt45YIVitamin D3 receptor/0.457
3wy0COAUncharacterized protein/0.457
4n57ADPAPH(2'')-Id/0.457
5im3DTPRibonucleoside-diphosphate reductase/0.457
1zemNADXylitol dehydrogenase/0.455
1ygkRRCPyridoxal kinase2.7.1.350.454
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.454
3vey0H5Glucokinase2.7.1.20.454
4gxs0YSGlutamate receptor 2/0.454
4kwhNAPReductase homolog/0.454
4nxuADPMitochondrial dynamics protein MID51/0.454
4q73FADBifunctional protein PutA/0.454
1ppjANYCytochrome b/0.453
2hog710Serine/threonine-protein kinase Chk12.7.11.10.453
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.453
3zh8C58Protein kinase C iota type2.7.11.130.453
2dr3ADPUPF0273 protein PH0284/0.452
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.452
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.451
2ejvNADL-threonine 3-dehydrogenase/0.451
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.451
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.451
3w33W19Epidermal growth factor receptor2.7.10.10.451
1i8tFADUDP-galactopyranose mutase5.4.99.90.450
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.450
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.449
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.449
2w06FRVCyclin-dependent kinase 22.7.11.220.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
3gobHXXDdmC/0.448
3ibdCPZCytochrome P450 2B61.14.130.448
3qruX19Cyclin-dependent kinase 22.7.11.220.448
3s1dZIRCytokinin dehydrogenase 11.5.99.120.448
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.447
1xddAAYIntegrin alpha-L/0.447
2e2qADPATP-dependent hexokinase/0.447
2w9hTOPDihydrofolate reductase1.5.1.30.447
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.447
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.447
2ahrNAPPyrroline-5-carboxylate reductase/0.446
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.446
3lgxATPD-alanine--poly(phosphoribitol) ligase subunit 1/0.446
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.446
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3uvqFS8Mitogen-activated protein kinase 14/0.445
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.445
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.445
4jq8KJ8Epidermal growth factor receptor2.7.10.10.445
5dc5B3NHistone deacetylase 83.5.1.980.445
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3poz03PEpidermal growth factor receptor2.7.10.10.444
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.444
4rosAPRMalate dehydrogenase/0.444
4xxgFADCholesterol oxidase1.1.3.60.444
1q4t4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.443
1r2jFADFkbI/0.443
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.443
3zewSTUEphrin type-B receptor 42.7.10.10.443
4q72FADBifunctional protein PutA/0.443
1u3dFADCryptochrome-1/0.442
1v1k3FPCyclin-dependent kinase 22.7.11.220.442
2d3mCOA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.442
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.442
3cbsR12Cellular retinoic acid-binding protein 2/0.442
3d7tSTUTyrosine-protein kinase CSK/0.442
3tqhNDPQuinone oxidoreductase/0.442
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.442
5k2cZMAAdenosine receptor A2a/0.442
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2wbdRO5Fructose-1,6-bisphosphatase 13.1.3.110.441
3rak03ZCyclin-dependent kinase 22.7.11.220.441
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.441
1pxxDIFProstaglandin G/H synthase 21.14.99.10.440
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
3stxBKAMethylketone synthase I/0.440
4jbqVX6Aurora kinase A2.7.11.10.440