sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 1.000 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.619 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.601 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.596 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.589 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.580 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.576 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.573 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.567 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.565 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.564 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
| 3qly | 55V | Uncharacterized protein | / | 0.557 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.555 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.540 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.536 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.533 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.533 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.530 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.529 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.529 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.527 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 3cse | N22 | Uncharacterized protein | / | 0.525 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.524 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.524 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.508 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3eem | 53V | Uncharacterized protein | / | 0.505 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.505 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.503 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.503 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3eej | 53R | Uncharacterized protein | / | 0.502 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.497 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.494 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.493 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.487 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.486 | |
| 3eek | 53S | Uncharacterized protein | / | 0.486 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3eel | 53T | Uncharacterized protein | / | 0.484 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.484 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.484 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.483 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.479 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.474 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.474 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.473 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.473 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.472 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.472 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.472 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.471 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.471 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.469 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.466 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.465 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.464 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.461 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.459 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.459 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2p15 | EZT | Estrogen receptor | / | 0.458 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.458 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.458 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.458 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.456 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.455 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.453 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.453 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.453 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.453 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.452 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.452 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.452 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.451 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.451 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.450 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.450 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4bmp | FMN | Protein NrdI | / | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.449 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.449 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.448 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.448 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.447 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.447 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.447 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.447 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.446 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 1ysx | 4EB | Serum albumin | / | 0.446 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.446 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.446 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.445 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.445 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.445 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.445 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.444 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.444 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.443 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.443 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.442 | |
| 1yin | CM3 | Estrogen receptor | / | 0.442 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.442 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.442 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3nks | ACJ | Protoporphyrinogen oxidase | 1.3.3.4 | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.441 | |
| 4azm | T4B | Fatty acid-binding protein, epidermal | / | 0.441 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.441 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.441 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.440 |