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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.41.000
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.628
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.620
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.612
2eq7FADDihydrolipoyl dehydrogenase/0.583
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.582
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.566
1geuFADGlutathione reductase1.8.1.70.563
1zx9FADMercuric reductase1.16.1.10.563
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.563
3ladFADDihydrolipoyl dehydrogenase/0.563
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.559
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.548
1zk7FADMercuric reductase1.16.1.10.540
1onfFADGlutathione reductase1.8.1.70.539
4jq9FADDihydrolipoyl dehydrogenase/0.536
3urhFADDihydrolipoyl dehydrogenase/0.529
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.528
2eq9FADDihydrolipoyl dehydrogenase/0.528
2yquFADDihydrolipoyl dehydrogenase/0.528
1gerFADGlutathione reductase1.8.1.70.525
2rabFADGlutathione amide reductase/0.523
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.520
2r9zFADGlutathione amide reductase/0.519
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.514
1grbFADGlutathione reductase, mitochondrial1.8.1.70.510
1greFADGlutathione reductase, mitochondrial1.8.1.70.510
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.510
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.509
2eq8FADDihydrolipoyl dehydrogenase/0.505
1getFADGlutathione reductase1.8.1.70.504
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.504
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.503
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.503
1grhFADGlutathione reductase, mitochondrial1.8.1.70.502
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.502
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.500
1graFADGlutathione reductase, mitochondrial1.8.1.70.499
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.498
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.498
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.495
1grgFADGlutathione reductase, mitochondrial1.8.1.70.493
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.493
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.489
3grsFADGlutathione reductase, mitochondrial1.8.1.70.489
3djgFADGlutathione reductase, mitochondrial1.8.1.70.487
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.486
4j56FADThioredoxin reductase 21.8.1.90.485
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.483
4eqsFADCoenzyme A disulfide reductase/0.480
4gcmFADThioredoxin reductase1.8.1.90.480
4emwFADCoenzyme A disulfide reductase/0.478
1nhpFADNADH peroxidase1.11.1.10.473
2q0lFADThioredoxin reductase1.8.1.90.470
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.470
1yqzFADCoenzyme A disulfide reductase/0.469
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.468
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.467
3ic9FADPutative dihydrolipoamide dehydrogenase/0.466
3ishFADThioredoxin reductase1.8.1.90.466
1nhqFADNADH peroxidase1.11.1.10.465
1febFADTrypanothione reductase1.8.1.120.463
1gteFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.462
3cgbFADCoenzyme A disulfide reductase/0.462
3cgdFADCoenzyme A disulfide reductase/0.462
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.462
2v6oFADThioredoxin glutathione reductase/0.458
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.453
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.452
3kkjFADRenalase/0.450
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.450
3ctyFADProbable thioredoxin reductase/0.449
4ykgFADAlkyl hydroperoxide reductase subunit F1.8.10.448
2q0kFADThioredoxin reductase1.8.1.90.446
3cgcFADCoenzyme A disulfide reductase/0.446
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.445
1f8wFADNADH peroxidase1.11.1.10.443
1k0lFADp-hydroxybenzoate hydroxylase/0.443
1tdfFADThioredoxin reductase1.8.1.90.440