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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1yqj6NPMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1yqj6NPMitogen-activated protein kinase 14/1.000
3zsh469Mitogen-activated protein kinase 14/0.526
3fl4FL4Mitogen-activated protein kinase 14/0.518
3itzP66Mitogen-activated protein kinase 14/0.500
1ouk084Mitogen-activated protein kinase 14/0.499
3flsFLSMitogen-activated protein kinase 14/0.498
3fmlFMLMitogen-activated protein kinase 14/0.496
3fkoFKOMitogen-activated protein kinase 14/0.493
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.489
1zzlTZYMitogen-activated protein kinase 14/0.489
1ove358Mitogen-activated protein kinase 14/0.488
3fknFKNMitogen-activated protein kinase 14/0.488
3fmmXI2Mitogen-activated protein kinase 14/0.487
1ywrLI9Mitogen-activated protein kinase 14/0.484
3flyFLYMitogen-activated protein kinase 14/0.482
3flwFLWMitogen-activated protein kinase 14/0.480
1w7h3IPMitogen-activated protein kinase 14/0.479
3fmn530Mitogen-activated protein kinase 14/0.479
3hub469Mitogen-activated protein kinase 14/0.479
3flzFLZMitogen-activated protein kinase 14/0.478
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
1bl6SB6Mitogen-activated protein kinase 14/0.476
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.474
3l8sBFFMitogen-activated protein kinase 14/0.474
1zhzERGOxysterol-binding protein homolog 4/0.473
3cv9VDXVitamin D3 dihydroxylase/0.473
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
4ewqMWLMitogen-activated protein kinase 14/0.473
4iarERM5-hydroxytryptamine receptor 1B/0.473
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.471
4mv1ADPBiotin carboxylase6.3.4.140.471
3dt1P40Mitogen-activated protein kinase 14/0.470
4nks2M2Fibroblast growth factor receptor 1/0.470
2pupADPMethylthioribose kinase2.7.1.1000.468
3zc3NAPFerredoxin--NADP reductase1.18.1.20.467
2gfsPQBMitogen-activated protein kinase 14/0.466
3ha85JZMitogen-activated protein kinase 14/0.466
1ouy094Mitogen-activated protein kinase 14/0.465
2w4qCBWProstaglandin reductase 21.3.1.480.465
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.465
1yinCM3Estrogen receptor/0.463
1l2jETCEstrogen receptor beta/0.462
2fszOHTEstrogen receptor beta/0.462
3lpfZ77Beta-glucuronidase3.2.1.310.461
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.460
2uxoTACHTH-type transcriptional regulator TtgR/0.460
2puiADPMethylthioribose kinase2.7.1.1000.459
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.459
1m7qDQOMitogen-activated protein kinase 14/0.458
1xuoLA1Integrin alpha-L/0.458
2vzmNRBCytochrome P450 monooxygenase PikC/0.458
4k9yK9YFocal adhesion kinase 12.7.10.20.458
4nc3ERM5-hydroxytryptamine receptor 2B/0.458
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.457
2ittAEEEpidermal growth factor receptor2.7.10.10.457
3hz5Z64Heat shock protein HSP 90-alpha/0.457
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.456
3iw5DF3Mitogen-activated protein kinase 14/0.456
4iaq2GM5-hydroxytryptamine receptor 1B/0.456
3fmh533Mitogen-activated protein kinase 14/0.455
3gc9B45Mitogen-activated protein kinase 112.7.11.240.455
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1errRALEstrogen receptor/0.454
2ibzSMACytochrome b/0.454
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3kf7L9GMitogen-activated protein kinase 14/0.454
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4ryvZEAProtein LlR18A/0.454
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.453
4jvmXDIEstrogen sulfotransferase2.8.2.40.453
2itpAEEEpidermal growth factor receptor2.7.10.10.452
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.452
2yixYIXMitogen-activated protein kinase 14/0.452
3hk1B64Fatty acid-binding protein, adipocyte/0.452
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.452
4gxs0YSGlutamate receptor 2/0.452
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.452
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
4elg52JDihydrofolate reductase/0.451
4jvlESTEstrogen sulfotransferase2.8.2.40.451
1fmlRTLRetinol dehydratase/0.450
1qknRALEstrogen receptor beta/0.450
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.450
2ewaSB2Mitogen-activated protein kinase 14/0.450
2qa2FADPolyketide oxygenase CabE/0.450
3ds6A17Mitogen-activated protein kinase 14/0.450
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4e5yNDPGDP-L-fucose synthase1.1.1.2710.450
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
3vtdTKDVitamin D3 receptor/0.449
1u0hONMAdenylate cyclase type 2/0.448
1u0hONMAdenylate cyclase type 5/0.448
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
3slkNDPPolyketide synthase extender module 2/0.448
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.448
4loqSB4Mitogen-activated protein kinase 14/0.448
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3d5wADPSerine/threonine-protein kinase PLK/0.447
3fln3FNMitogen-activated protein kinase 14/0.447
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4iwc1GVEstrogen receptor/0.447
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
1zyjBI5Mitogen-activated protein kinase 14/0.446
3hl7I47Mitogen-activated protein kinase 14/0.446
4eh60ONMitogen-activated protein kinase 14/0.446
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.446
1osvCHCBile acid receptor/0.445
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2ydoADNAdenosine receptor A2a/0.445
3fi4FI4Mitogen-activated protein kinase 14/0.445
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4b8wNAPGDP-L-fucose synthase1.1.1.2710.445
1bmkSB5Mitogen-activated protein kinase 14/0.444
1ppjANYCytochrome b/0.444
1u4dDBQActivated CDC42 kinase 1/0.444
2aibERGBeta-elicitin cinnamomin/0.444
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.444
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4ib4ERM5-hydroxytryptamine receptor 2B/0.444
5k2aZMAAdenosine receptor A2a/0.444
1dkfBMSRetinoic acid receptor alpha/0.443
1mvsDTMDihydrofolate reductase1.5.1.30.443
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.443
2pulACPMethylthioribose kinase2.7.1.1000.443
3fmjFMJMitogen-activated protein kinase 14/0.443
4jq7KJQEpidermal growth factor receptor2.7.10.10.443
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
2bxnIDBSerum albumin/0.442
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.442
2uxuNARHTH-type transcriptional regulator TtgR/0.442
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
4ybnFADFlavin-nucleotide-binding protein/0.442
5k2cZMAAdenosine receptor A2a/0.442
1cbrREACellular retinoic acid-binding protein 1/0.441
1uyfPU1Heat shock protein HSP 90-alpha/0.441
2z3uCRRCytochrome P450/0.441
3fc152PMitogen-activated protein kinase 14/0.441
3vt8YI3Vitamin D3 receptor/0.441
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
5iqiGNPBifunctional AAC/APH2.3.10.441
1jlcFTCGag-Pol polyprotein2.7.7.490.440
1zhwHC2Oxysterol-binding protein homolog 4/0.440
5iqhGNPBifunctional AAC/APH2.3.10.440