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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tktH12Gag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tktH12Gag-Pol polyprotein2.7.7.491.000
1tl3H20Gag-Pol polyprotein2.7.7.490.765
1tl1H18Gag-Pol polyprotein2.7.7.490.749
1tkzH16Gag-Pol polyprotein2.7.7.490.741
1revTB9Gag-Pol polyprotein2.7.7.490.668
1s1wUC1Gag-Pol polyprotein2.7.7.490.643
1vruAAPGag-Pol polyprotein2.7.7.490.628
1c1bGCAGag-Pol polyprotein2.7.7.490.609
2opqHBQGag-Pol polyprotein2.7.7.490.607
1rt4UC1Gag-Pol polyprotein2.7.7.490.604
3qlhT27Gag-Pol polyprotein2.7.7.490.591
1ikwEFZGag-Pol polyprotein2.7.7.490.585
1s6qTPBGag-Pol polyprotein2.7.7.490.585
2zd1T27Gag-Pol polyprotein2.7.7.490.584
1hnvTBOGag-Pol polyprotein2.7.7.490.580
4i2pG73Gag-Pol polyprotein2.7.7.490.579
4ko0JLJGag-Pol polyprotein2.7.7.490.578
3i0rRT3Gag-Pol polyprotein2.7.7.490.576
1rt5UC2Gag-Pol polyprotein2.7.7.490.572
2hnzPC0Gag-Pol polyprotein2.7.7.490.572
3is9AC7Gag-Pol polyprotein2.7.7.490.569
4kko1REGag-Pol polyprotein2.7.7.490.569
1hpzAAPGag-Pol polyprotein2.7.7.490.567
3lamKRPGag-Pol polyprotein2.7.7.490.561
1s9eADBGag-Pol polyprotein2.7.7.490.559
3irxUDRGag-Pol polyprotein2.7.7.490.559
1hquHBYGag-Pol polyprotein2.7.7.490.558
1ikyMSDGag-Pol polyprotein2.7.7.490.557
1tvrTB9Gag-Pol polyprotein2.7.7.490.556
3ffi3OBGag-Pol polyprotein2.7.7.490.556
4ifvT27Gag-Pol polyprotein2.7.7.490.553
4id5T27Gag-Pol polyprotein2.7.7.490.552
2ze2T27Gag-Pol polyprotein2.7.7.490.551
3dmjGWEPol protein/0.551
1eetBFUGag-Pol polyprotein2.7.7.490.549
2oppHBQGag-Pol polyprotein2.7.7.490.549
2vg7NNIGag-Pol polyprotein2.7.7.490.549
3meeT27Gag-Pol polyprotein2.7.7.490.549
1rt2TNKGag-Pol polyprotein2.7.7.490.546
4ig3T27Gag-Pol polyprotein2.7.7.490.546
2rf2MRXGag-Pol polyprotein2.7.7.490.544
1ep4S11Gag-Pol polyprotein2.7.7.490.542
1ikvEFZGag-Pol polyprotein2.7.7.490.538
2hndNVPGag-Pol polyprotein2.7.7.490.536
4g1qT27Gag-Pol polyprotein2.7.7.490.536
1ikxPNUGag-Pol polyprotein2.7.7.490.534
1hniAAAGag-Pol polyprotein2.7.7.490.533
3megT27Gag-Pol polyprotein2.7.7.490.532
1s1tUC1Gag-Pol polyprotein2.7.7.490.531
3nbpJGZGag-Pol polyprotein2.7.7.490.531
2ban357Gag-Pol polyprotein2.7.7.490.530
5cyqT27Gag-Pol polyprotein2.7.7.490.526
1rt7UC4Gag-Pol polyprotein2.7.7.490.525
1tkxGWBGag-Pol polyprotein2.7.7.490.522
3dleGFAGag-Pol polyprotein2.7.7.490.522
1fk9EFZGag-Pol polyprotein2.7.7.490.519
3i0sRT7Gag-Pol polyprotein2.7.7.490.516
1rt1MKCGag-Pol polyprotein2.7.7.490.514
3med65BGag-Pol polyprotein2.7.7.490.510
1jlgUC1Gag-Pol polyprotein2.7.7.490.508
2opsHBQGag-Pol polyprotein2.7.7.490.505
3m8qDJZGag-Pol polyprotein2.7.7.490.505
4i2q1BTGag-Pol polyprotein2.7.7.490.505
2vg5NNCGag-Pol polyprotein2.7.7.490.504
4rw6494Gag-Pol polyprotein2.7.7.490.503
3m8p65BGag-Pol polyprotein2.7.7.490.498
1jlaTNKGag-Pol polyprotein2.7.7.490.497
3c6uM22Gag-Pol polyprotein2.7.7.490.494
3mec65BGag-Pol polyprotein2.7.7.490.493
1jlcFTCGag-Pol polyprotein2.7.7.490.491
2ic3HBYGag-Pol polyprotein2.7.7.490.491
3lalKRVGag-Pol polyprotein2.7.7.490.488
4jvmXDIEstrogen sulfotransferase2.8.2.40.488
1fkoEFZGag-Pol polyprotein2.7.7.490.487
1jlqSBNGag-Pol polyprotein2.7.7.490.487
3lanKBTGag-Pol polyprotein2.7.7.490.487
1klmSPPGag-Pol polyprotein2.7.7.490.485
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.485
3bgrT27Gag-Pol polyprotein2.7.7.490.479
4mfb29TGag-Pol polyprotein2.7.7.490.477
2oprHBQGag-Pol polyprotein2.7.7.490.475
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.469
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.467
2zjwREFCasein kinase II subunit alpha2.7.11.10.464
4lsl1YQGag-Pol polyprotein2.7.7.490.464
4kfbT27Gag-Pol polyprotein2.7.7.490.462
2jb4A14Isopenicillin N synthase1.21.3.10.461
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
1bk0ACVIsopenicillin N synthase1.21.3.10.459
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.459
3p3zP3ZPutative cytochrome P450/0.459
1o5rFR9Adenosine deaminase3.5.4.40.457
1ot7CHCBile acid receptor/0.457
1qxlFR8Adenosine deaminase3.5.4.40.457
3d7kD7KBenzaldehyde lyase/0.457
1kl2FONSerine hydroxymethyltransferase/0.456
3rmf20ZCyclin-dependent kinase 22.7.11.220.456
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
1oitHDTCyclin-dependent kinase 22.7.11.220.453
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
3a1l2CCCytochrome P450/0.453
3cv9VDXVitamin D3 dihydroxylase/0.453
3s1h56ZCyclin-dependent kinase 22.7.11.220.453
2c7xNRBCytochrome P450 monooxygenase PikC/0.452
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
3ctj320Hepatocyte growth factor receptor2.7.10.10.451
3dokGWJPol protein/0.451
3m0eATPTranscriptional regulator (NtrC family)/0.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.451
1s19MC9Vitamin D3 receptor/0.450
1v7aFRCAdenosine deaminase3.5.4.40.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.450
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4anmWULCasein kinase II subunit alpha2.7.11.10.449
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.448
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4uymVOR14-alpha sterol demethylase Cyp51B/0.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
3s79ASDAromatase1.14.14.140.447
3zkyWT4Isopenicillin N synthase1.21.3.10.447
4o761M3Bromodomain-containing protein 4/0.447
1dkfBMSRetinoic acid receptor alpha/0.446
2jn3JN3Fatty acid-binding protein, liver/0.446
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1fmlRTLRetinol dehydratase/0.445
1jpaANPEphrin type-B receptor 22.7.10.10.445
2bxoOPBSerum albumin/0.445
3u4uLNHCasein kinase II subunit alpha2.7.11.10.445
4ejh0QACytochrome P450 2A131.14.14.10.445
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1ot7IU5Bile acid receptor/0.444
4fkv61KCyclin-dependent kinase 22.7.11.220.444
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1fmjRTLRetinol dehydratase/0.443
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.443
3gc9B45Mitogen-activated protein kinase 112.7.11.240.443
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.443
4ii5ADPCyclin-dependent kinase 22.7.11.220.443
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1uymPU3Heat shock protein HSP 90-beta/0.442
3wgwT2BProliferating cell nuclear antigen/0.442
1ek2CDUBifunctional epoxide hydrolase 2/0.441
1hb3SCVIsopenicillin N synthase1.21.3.10.441
1n4hREANuclear receptor ROR-beta/0.441
1osvCHCBile acid receptor/0.441
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
3mnrSD1Heat shock protein HSP 90-alpha/0.441
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4c2yMYAGlycylpeptide N-tetradecanoyltransferase 1/0.441
4ocvANPAminoglycoside phosphotransferase/0.441
2vf0F89Thymidylate synthase/0.440
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.440
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.440
3vt7VDXVitamin D3 receptor/0.440
4j6cSTRCytochrome P450 monooxygenase/0.440
4jx1CAMCamphor 5-monooxygenase1.14.15.10.440
4nb6444Nuclear receptor ROR-gamma/0.440
4nmbFADBifunctional protein PutA/0.440
4pkl1GHUncharacterized protein/0.440