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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.21.000
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.625
1njsKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.583
1rc0KT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.582
1rbzKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.546
1c2tNHSPhosphoribosylglycinamide formyltransferase/0.534
1c3eNHRPhosphoribosylglycinamide formyltransferase/0.509
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.479
4uymVOR14-alpha sterol demethylase Cyp51B/0.476
1jkx138Phosphoribosylglycinamide formyltransferase/0.472
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.472
3iobA4DPantothenate synthetase6.3.2.10.471
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.470
3ik6HCZGlutamate receptor 2/0.469
2q5g1FAPeroxisome proliferator-activated receptor delta/0.468
3isjA8DPantothenate synthetase6.3.2.10.468
4g7gVFVLanosterol 14-alpha-demethylase/0.468
2xlsFADPutative flavin-containing monooxygenase/0.467
1cdeDZFPhosphoribosylglycinamide formyltransferase/0.466
5hs1VORLanosterol 14-alpha demethylase/0.464
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.461
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.461
4nxwADPMitochondrial dynamics protein MID51/0.461
4xgxADPFAD:protein FMN transferase/0.461
2fy5SOPCholine O-acetyltransferase2.3.1.60.460
2xviFADPutative flavin-containing monooxygenase/0.460
3a9wNADNDP-sugar epimerase/0.460
1khrVIRStreptogramin A acetyltransferase2.3.10.458
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.458
3a1nNADNDP-sugar epimerase/0.458
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.457
3h6vNS6Glutamate receptor 2/0.457
1xl5190Gag-Pol polyprotein3.4.23.160.456
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.455
2z1mNDPGDP-mannose 4,6-dehydratase/0.455
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.455
3t2zFADSulfide-quinone reductase/0.455
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.455
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.454
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.454
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.454
1fm9570Peroxisome proliferator-activated receptor gamma/0.453
1xddAAYIntegrin alpha-L/0.453
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.453
3imeBZ2Pantothenate synthetase6.3.2.10.452
2xlrFADPutative flavin-containing monooxygenase/0.451
3hwrNDP2-dehydropantoate 2-reductase/0.451
3pqbVGPPutative oxidoreductase/0.451
3tneRITCandidapepsin-13.4.23.240.451
3wmxNADNAD dependent epimerase/dehydratase/0.451
4g6hFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
3adaNADSubunit alpha of sarocosine oxidase/0.450
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2ath3EAPeroxisome proliferator-activated receptor gamma/0.449
2gjlFMNNitronate monooxygenase1.13.12.160.449
2npaMMBPeroxisome proliferator-activated receptor alpha/0.449
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.449
4xldBRLPeroxisome proliferator-activated receptor gamma/0.449
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.448
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.448
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.448
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1kkq471Peroxisome proliferator-activated receptor alpha/0.447
2q61SF1Peroxisome proliferator-activated receptor gamma/0.447
2y3rTRKTamL/0.447
2znnS44Peroxisome proliferator-activated receptor alpha/0.447
3vspEK8Peroxisome proliferator-activated receptor gamma/0.447
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.447
4ia2BIVVitamin D3 receptor A/0.447
3gxlQIGTGF-beta receptor type-12.7.11.300.446
3iocA5DPantothenate synthetase6.3.2.10.446
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.446
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.445
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.445
3h8bNSYCathepsin L13.4.22.150.445
2gtk208Peroxisome proliferator-activated receptor gamma/0.444
3i99FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
3kp4MIITranscriptional regulator TcaR/0.444
3lixE17Protease/0.444
4hgs15GCasein kinase I isoform gamma-32.7.11.10.444
4q73FADBifunctional protein PutA/0.444
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3ogqAB1Pol polyprotein/0.443
3sufSUEPolyprotein/0.443
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.442
2cig1DGDihydrofolate reductase1.5.1.30.442
2ou2ACOHistone acetyltransferase KAT5/0.442
3sdkP3NProteasome subunit beta type-53.4.25.10.442
3sdkP3NProteasome subunit beta type-63.4.25.10.442
3v9v21LPeroxisome proliferator-activated receptor gamma/0.442
4bfvZVVPantothenate kinase2.7.1.330.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.441
3c212BADNA integrity scanning protein DisA/0.441
3l6jZ90Alr2278 protein/0.441
3oiaA31Camphor 5-monooxygenase1.14.15.10.441
3tz3B36Acetyl-CoA carboxylase/0.441
4b7xNAPProbable oxidoreductase/0.441
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3v9y24LPeroxisome proliferator-activated receptor gamma/0.440
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.440
4iah1DXAlr2278 protein/0.440
4uyf73BBromodomain-containing protein 2/0.440